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All-cause and cause-specific mortality after hip fracture among Chinese women and men: the Singapore Chinese Health Study.
Osteoporos Int 2013; 24(7):1981-9OI

Abstract

All-cause mortality risk persisted for 5 years after hip fractures in both men and women. There may be gender-specific differences in effect and duration of excess risk for cause-specific mortality after hip fracture.

INTRODUCTION

To determine all-cause and cause-specific mortality risk in the first 5 years after hip fracture in an Asian Chinese population.

METHODS

The Singapore Chinese Health Study is a population-based cohort of 63,257 middle-aged and elderly Chinese men and women in Singapore recruited between 1993 and 1998. This cohort was followed up for hip fracture and death via linkage with nationwide hospital discharge database and death registry. As of 31 December 2008, we identified 1,166 hip fracture cases and matched five non-fracture cohort subjects by age and gender for each fracture case. Cox proportional hazards and competing risks regression models with hip fracture as a time-dependent covariate were used to determine all-cause and cause-specific mortality risk, respectively.

RESULTS

Increase in all-cause mortality risk persisted till 5 years after hip fracture (adjusted hazard ratio, aHR = 1.58 [95 % CI, 1.35-1.86] for females and aHR = 1.64 [95 % CI, 1.30-2.06] for males). Men had higher mortality risk after hip fracture than women for deaths from stroke and cancer up to 1 year post-fracture but women with hip fracture had higher coronary artery mortality risk than men for 5 years post-fracture. Men had higher risk of death from pneumonia while women had increased risk of death from urinary tract infections. There was no difference in mortality risk by types of hip fracture surgery.

CONCLUSIONS

All-cause mortality risk persisted for 5 years after hip fractures in men and women. There are gender-specific differences in effect size and duration of excess mortality risk from hip fractures between specific causes of death.

Authors+Show Affiliations

Saw Swee Hock School of Public Health, National University of Singapore, National University Health System, Block MD3, #03-20, 16 Medical Drive, 117597 Singapore, Singapore. Gerald_Koh@nuhs.edu.sgNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

23224227

Citation

Koh, G C-H, et al. "All-cause and Cause-specific Mortality After Hip Fracture Among Chinese Women and Men: the Singapore Chinese Health Study." Osteoporosis International : a Journal Established as Result of Cooperation Between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA, vol. 24, no. 7, 2013, pp. 1981-9.
Koh GC, Tai BC, Ang LW, et al. All-cause and cause-specific mortality after hip fracture among Chinese women and men: the Singapore Chinese Health Study. Osteoporos Int. 2013;24(7):1981-9.
Koh, G. C., Tai, B. C., Ang, L. W., Heng, D., Yuan, J. M., & Koh, W. P. (2013). All-cause and cause-specific mortality after hip fracture among Chinese women and men: the Singapore Chinese Health Study. Osteoporosis International : a Journal Established as Result of Cooperation Between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA, 24(7), pp. 1981-9. doi:10.1007/s00198-012-2183-7.
Koh GC, et al. All-cause and Cause-specific Mortality After Hip Fracture Among Chinese Women and Men: the Singapore Chinese Health Study. Osteoporos Int. 2013;24(7):1981-9. PubMed PMID: 23224227.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - All-cause and cause-specific mortality after hip fracture among Chinese women and men: the Singapore Chinese Health Study. AU - Koh,G C-H, AU - Tai,B C, AU - Ang,L-W, AU - Heng,D, AU - Yuan,J-M, AU - Koh,W-P, Y1 - 2012/12/09/ PY - 2012/06/24/received PY - 2012/09/28/accepted PY - 2012/12/11/entrez PY - 2012/12/12/pubmed PY - 2014/2/20/medline SP - 1981 EP - 9 JF - Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA JO - Osteoporos Int VL - 24 IS - 7 N2 - UNLABELLED: All-cause mortality risk persisted for 5 years after hip fractures in both men and women. There may be gender-specific differences in effect and duration of excess risk for cause-specific mortality after hip fracture. INTRODUCTION: To determine all-cause and cause-specific mortality risk in the first 5 years after hip fracture in an Asian Chinese population. METHODS: The Singapore Chinese Health Study is a population-based cohort of 63,257 middle-aged and elderly Chinese men and women in Singapore recruited between 1993 and 1998. This cohort was followed up for hip fracture and death via linkage with nationwide hospital discharge database and death registry. As of 31 December 2008, we identified 1,166 hip fracture cases and matched five non-fracture cohort subjects by age and gender for each fracture case. Cox proportional hazards and competing risks regression models with hip fracture as a time-dependent covariate were used to determine all-cause and cause-specific mortality risk, respectively. RESULTS: Increase in all-cause mortality risk persisted till 5 years after hip fracture (adjusted hazard ratio, aHR = 1.58 [95 % CI, 1.35-1.86] for females and aHR = 1.64 [95 % CI, 1.30-2.06] for males). Men had higher mortality risk after hip fracture than women for deaths from stroke and cancer up to 1 year post-fracture but women with hip fracture had higher coronary artery mortality risk than men for 5 years post-fracture. Men had higher risk of death from pneumonia while women had increased risk of death from urinary tract infections. There was no difference in mortality risk by types of hip fracture surgery. CONCLUSIONS: All-cause mortality risk persisted for 5 years after hip fractures in men and women. There are gender-specific differences in effect size and duration of excess mortality risk from hip fractures between specific causes of death. SN - 1433-2965 UR - https://www.unboundmedicine.com/medline/citation/23224227/All_cause_and_cause_specific_mortality_after_hip_fracture_among_Chinese_women_and_men:_the_Singapore_Chinese_Health_Study_ L2 - https://dx.doi.org/10.1007/s00198-012-2183-7 DB - PRIME DP - Unbound Medicine ER -