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MED12 mutations occurring in benign and malignant mammalian smooth muscle tumors.
Genes Chromosomes Cancer. 2013 Mar; 52(3):297-304.GC

Abstract

Mutations of the mediator subcomplex 12 gene (MED12) recently have been described in a large group of uterine leiomyomas (UL) but only in a single malignant uterine smooth muscle tumor. To further address the occurrence of fibroid-type MED12 mutations in smooth muscle tumors, we have analyzed samples from 34 leiomyosarcomas (LMS), 21 UL, two extrauterine leiomyomas (EL), and 10 canine genital leiomyomas for the presence of MED12 mutations of the UL-type. Interestingly, besides UL MED12 mutations were found in one uterine LMS, one EL, and two canine vaginal leiomyomas. The results confirm the occurrence of fibroid-type MED12 mutations in malignant uterine smooth muscle tumors thus suggesting a rare but existing leiomyoma-LMS sequence. In addition, for the first time MED12 mutations are reported in smooth muscle tumors in a non-primate mammalian species.

Authors+Show Affiliations

Center of Human Genetics, University of Bremen, Leobener Strasse ZHG, D-28359 Bremen, Germany.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

23225304

Citation

Markowski, Dominique Nadine, et al. "MED12 Mutations Occurring in Benign and Malignant Mammalian Smooth Muscle Tumors." Genes, Chromosomes & Cancer, vol. 52, no. 3, 2013, pp. 297-304.
Markowski DN, Huhle S, Nimzyk R, et al. MED12 mutations occurring in benign and malignant mammalian smooth muscle tumors. Genes Chromosomes Cancer. 2013;52(3):297-304.
Markowski, D. N., Huhle, S., Nimzyk, R., Stenman, G., Löning, T., & Bullerdiek, J. (2013). MED12 mutations occurring in benign and malignant mammalian smooth muscle tumors. Genes, Chromosomes & Cancer, 52(3), 297-304. https://doi.org/10.1002/gcc.22029
Markowski DN, et al. MED12 Mutations Occurring in Benign and Malignant Mammalian Smooth Muscle Tumors. Genes Chromosomes Cancer. 2013;52(3):297-304. PubMed PMID: 23225304.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - MED12 mutations occurring in benign and malignant mammalian smooth muscle tumors. AU - Markowski,Dominique Nadine, AU - Huhle,Sonja, AU - Nimzyk,Rolf, AU - Stenman,Göran, AU - Löning,Thomas, AU - Bullerdiek,Jörn, Y1 - 2012/12/08/ PY - 2012/07/18/received PY - 2012/10/11/accepted PY - 2012/12/11/entrez PY - 2012/12/12/pubmed PY - 2013/6/13/medline SP - 297 EP - 304 JF - Genes, chromosomes & cancer JO - Genes Chromosomes Cancer VL - 52 IS - 3 N2 - Mutations of the mediator subcomplex 12 gene (MED12) recently have been described in a large group of uterine leiomyomas (UL) but only in a single malignant uterine smooth muscle tumor. To further address the occurrence of fibroid-type MED12 mutations in smooth muscle tumors, we have analyzed samples from 34 leiomyosarcomas (LMS), 21 UL, two extrauterine leiomyomas (EL), and 10 canine genital leiomyomas for the presence of MED12 mutations of the UL-type. Interestingly, besides UL MED12 mutations were found in one uterine LMS, one EL, and two canine vaginal leiomyomas. The results confirm the occurrence of fibroid-type MED12 mutations in malignant uterine smooth muscle tumors thus suggesting a rare but existing leiomyoma-LMS sequence. In addition, for the first time MED12 mutations are reported in smooth muscle tumors in a non-primate mammalian species. SN - 1098-2264 UR - https://www.unboundmedicine.com/medline/citation/23225304/MED12_mutations_occurring_in_benign_and_malignant_mammalian_smooth_muscle_tumors_ L2 - https://doi.org/10.1002/gcc.22029 DB - PRIME DP - Unbound Medicine ER -