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Monitoring of the interconversion of gamma-butyrolactone (GBL) to gamma hydroxybutyric acid (GHB) by Raman spectroscopy.
Drug Test Anal. 2013 Aug; 5(8):678-82.DT

Abstract

Gamma-hydroxybutyric acid (GHB) is a drug-of-abuse that has recently become associated with drug-facilitated sexual assault, known as date rape. For this reason the drug is commonly found 'spiked' in alcoholic beverages. When GHB is in solution it may undergo conversion into the corresponding lactone, Gamma-butyrolactone (GBL). Studies have been carried out to determine the detection limits of GHB and GBL in various solutions by Raman spectroscopy and to monitor the interconversion of GHB and GBL in solution with different pH conditions and temperature. In this study, a portable Raman spectrometer was used to study the interconversion of GHB and GBL in water and ethanol solutions as a function of pH, time, and temperature. The aim of this was to determine the optimum pH range for conversion in order to relate this to the pH ranges that the drug is likely to be subjected to, first in spiked beverages and secondly after ingestion in the digestive system. The aim was also to identify a timescale for this conversion in relation to possible scenarios, for example if GHB takes a number of hours to convert to GBL, it is likely for the beverage to be ingested before esterification can take place. GHB and GBL were then spiked into a selection of beverages of known pH in order to study the stability of GHB and GBL in real systems.

Authors+Show Affiliations

Chemical & Forensic Sciences, University of Bradford, Bradford, BD7 1DP, UK. t.munshi@bradford.ac.ukNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

23225646

Citation

Munshi, Tasnim, et al. "Monitoring of the Interconversion of Gamma-butyrolactone (GBL) to Gamma Hydroxybutyric Acid (GHB) By Raman Spectroscopy." Drug Testing and Analysis, vol. 5, no. 8, 2013, pp. 678-82.
Munshi T, Brewster VL, Edwards HG, et al. Monitoring of the interconversion of gamma-butyrolactone (GBL) to gamma hydroxybutyric acid (GHB) by Raman spectroscopy. Drug Test Anal. 2013;5(8):678-82.
Munshi, T., Brewster, V. L., Edwards, H. G., Hargreaves, M. D., Jilani, S. K., & Scowen, I. J. (2013). Monitoring of the interconversion of gamma-butyrolactone (GBL) to gamma hydroxybutyric acid (GHB) by Raman spectroscopy. Drug Testing and Analysis, 5(8), 678-82. https://doi.org/10.1002/dta.1438
Munshi T, et al. Monitoring of the Interconversion of Gamma-butyrolactone (GBL) to Gamma Hydroxybutyric Acid (GHB) By Raman Spectroscopy. Drug Test Anal. 2013;5(8):678-82. PubMed PMID: 23225646.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Monitoring of the interconversion of gamma-butyrolactone (GBL) to gamma hydroxybutyric acid (GHB) by Raman spectroscopy. AU - Munshi,Tasnim, AU - Brewster,Victoria L, AU - Edwards,Howell G M, AU - Hargreaves,Michael D, AU - Jilani,Shelina K, AU - Scowen,Ian J, Y1 - 2012/12/06/ PY - 2012/07/23/received PY - 2012/10/15/revised PY - 2012/10/16/accepted PY - 2012/12/11/entrez PY - 2012/12/12/pubmed PY - 2014/3/7/medline KW - GBL, alcoholic beverages KW - Raman Spectroscopy KW - pH KW - temperature, GHB SP - 678 EP - 82 JF - Drug testing and analysis JO - Drug Test Anal VL - 5 IS - 8 N2 - Gamma-hydroxybutyric acid (GHB) is a drug-of-abuse that has recently become associated with drug-facilitated sexual assault, known as date rape. For this reason the drug is commonly found 'spiked' in alcoholic beverages. When GHB is in solution it may undergo conversion into the corresponding lactone, Gamma-butyrolactone (GBL). Studies have been carried out to determine the detection limits of GHB and GBL in various solutions by Raman spectroscopy and to monitor the interconversion of GHB and GBL in solution with different pH conditions and temperature. In this study, a portable Raman spectrometer was used to study the interconversion of GHB and GBL in water and ethanol solutions as a function of pH, time, and temperature. The aim of this was to determine the optimum pH range for conversion in order to relate this to the pH ranges that the drug is likely to be subjected to, first in spiked beverages and secondly after ingestion in the digestive system. The aim was also to identify a timescale for this conversion in relation to possible scenarios, for example if GHB takes a number of hours to convert to GBL, it is likely for the beverage to be ingested before esterification can take place. GHB and GBL were then spiked into a selection of beverages of known pH in order to study the stability of GHB and GBL in real systems. SN - 1942-7611 UR - https://www.unboundmedicine.com/medline/citation/23225646/Monitoring_of_the_interconversion_of_gamma_butyrolactone__GBL__to_gamma_hydroxybutyric_acid__GHB__by_Raman_spectroscopy_ DB - PRIME DP - Unbound Medicine ER -