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Predicting cortical bone strength from DXA and dental cone-beam CT.
PLoS One. 2012; 7(11):e50008.Plos

Abstract

OBJECTIVE

This study compared the capabilities of dual-energy X-ray absorptiometry (DXA) and dental cone-beam computed tomography (CBCT) for predicting the cortical bone strength of rat femurs and tibias.

MATERIALS AND METHODS

Specimens of femurs and tibias obtained from 14 rats were first scanned with DXA to obtain the areal bone mineral density (BMD) of the midshaft cortical portion of the bones. The bones were then scanned using dental CBCT to measure the volumetric cortical bone mineral density (vCtBMD) and the cross-sectional moment of inertia (CSMI) for calculating the bone strength index (BSI). A three-point bending test was conducted to measure the fracture load of each femur and tibia. Bivariate linear Pearson analysis was used to calculate the correlation coefficients (r values) among the CBCT measurements, DXA measurements, and three-point bending parameters.

RESULTS

The correlation coefficients for the associations of the fracture load with areal BMD (measured using DXA), vCtBMD (measured using CBCT), CSMI (measured using CBCT), and BSI were 0.585 (p = 0.028) and 0.532 (p = 0.050) (for the femur and tibia, respectively), 0.638 (p = 0.014) and 0.762 (p = 0.002), 0.778 (p = 0.001) and 0.792 (p<0.001), and 0.822 (p<0.001) and 0.842 (p<0.001), respectively.

CONCLUSIONS

CBCT was found to be superior to DXA for predicting cortical bone fracture loads in rat femurs and tibias. The BSI, which is a combined index of densitometric and geometric parameters, was especially useful. Further clinical studies are needed to validate the predictive value of BSI obtained from CBCT and should include testing on human cadaver specimens.

Authors+Show Affiliations

School of Dentistry, College of Medicine, China Medical University, Taichung, Taiwan.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

23226234

Citation

Hsu, Jui-Ting, et al. "Predicting Cortical Bone Strength From DXA and Dental Cone-beam CT." PloS One, vol. 7, no. 11, 2012, pp. e50008.
Hsu JT, Chen YJ, Tsai MT, et al. Predicting cortical bone strength from DXA and dental cone-beam CT. PLoS One. 2012;7(11):e50008.
Hsu, J. T., Chen, Y. J., Tsai, M. T., Lan, H. H., Cheng, F. C., Chen, M. Y., & Wang, S. P. (2012). Predicting cortical bone strength from DXA and dental cone-beam CT. PloS One, 7(11), e50008. https://doi.org/10.1371/journal.pone.0050008
Hsu JT, et al. Predicting Cortical Bone Strength From DXA and Dental Cone-beam CT. PLoS One. 2012;7(11):e50008. PubMed PMID: 23226234.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Predicting cortical bone strength from DXA and dental cone-beam CT. AU - Hsu,Jui-Ting, AU - Chen,Ying-Ju, AU - Tsai,Ming-Tzu, AU - Lan,Howard Haw-Chang, AU - Cheng,Fu-Chou, AU - Chen,Michael Y C, AU - Wang,Shun-Ping, Y1 - 2012/11/30/ PY - 2012/07/06/received PY - 2012/10/15/accepted PY - 2012/12/11/entrez PY - 2012/12/12/pubmed PY - 2013/5/22/medline SP - e50008 EP - e50008 JF - PloS one JO - PLoS One VL - 7 IS - 11 N2 - OBJECTIVE: This study compared the capabilities of dual-energy X-ray absorptiometry (DXA) and dental cone-beam computed tomography (CBCT) for predicting the cortical bone strength of rat femurs and tibias. MATERIALS AND METHODS: Specimens of femurs and tibias obtained from 14 rats were first scanned with DXA to obtain the areal bone mineral density (BMD) of the midshaft cortical portion of the bones. The bones were then scanned using dental CBCT to measure the volumetric cortical bone mineral density (vCtBMD) and the cross-sectional moment of inertia (CSMI) for calculating the bone strength index (BSI). A three-point bending test was conducted to measure the fracture load of each femur and tibia. Bivariate linear Pearson analysis was used to calculate the correlation coefficients (r values) among the CBCT measurements, DXA measurements, and three-point bending parameters. RESULTS: The correlation coefficients for the associations of the fracture load with areal BMD (measured using DXA), vCtBMD (measured using CBCT), CSMI (measured using CBCT), and BSI were 0.585 (p = 0.028) and 0.532 (p = 0.050) (for the femur and tibia, respectively), 0.638 (p = 0.014) and 0.762 (p = 0.002), 0.778 (p = 0.001) and 0.792 (p<0.001), and 0.822 (p<0.001) and 0.842 (p<0.001), respectively. CONCLUSIONS: CBCT was found to be superior to DXA for predicting cortical bone fracture loads in rat femurs and tibias. The BSI, which is a combined index of densitometric and geometric parameters, was especially useful. Further clinical studies are needed to validate the predictive value of BSI obtained from CBCT and should include testing on human cadaver specimens. SN - 1932-6203 UR - https://www.unboundmedicine.com/medline/citation/23226234/Predicting_cortical_bone_strength_from_DXA_and_dental_cone_beam_CT_ L2 - https://dx.plos.org/10.1371/journal.pone.0050008 DB - PRIME DP - Unbound Medicine ER -