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Interactions between serum vitamin D levels and vitamin D receptor gene FokI polymorphisms for renal function in patients with type 2 diabetes.
PLoS One. 2012; 7(12):e51171.Plos

Abstract

BACKGROUND

We aimed to examine associations among serum 25-hydroxyvitamin D (25OHD) levels, 1,25-dihyroxyvitamin D (1,25OHD) levels, vitamin D receptor (VDR) polymorphisms, and renal function based on estimated glomerular filtration rate (eGFR) in patients with type 2 diabetes.

METHODS

In a cross-sectional study of 410 patients, chronic kidney disease (CKD) stage assessed by eGFR was compared with 25OHD, 1,25OHD, and VDR FokI (rs10735810) polymorphisms by an ordered logistic regression model adjusted for the following confounders: disease duration, calendar month, use of angiotensin converting enzyme inhibitors/angiotensin receptor blockers or statins, and serum calcium, phosphate, and intact parathyroid hormone levels.

RESULTS

1,25OHD levels, rather than 25OHD levels, showed seasonal oscillations; peak levels were seen from May to October and the lowest levels were seen from December to February. These findings were evident in patients with CKD stage 3 ~ 5 but not stage 1 ~ 2. eGFR was in direct proportion to both 25OHD and 1,25OHD levels (P<0.0001), but it had stronger linearity with 1,25OHD (r = 0.73) than 25OHD (r = 0.22) levels. Using multivariate analysis, 1,25OHD levels (P<0.001), but not 25OHD levels, were negatively associated with CKD stage. Although FokI polymorphisms by themselves showed no significant associations with CKD stage, a significant interaction between 1,25OHD and FokITT was observed (P = 0.008). The positive association between 1,25OHD and eGFR was steeper in FokICT and CC polymorphisms (r = 0.74) than FokITT polymorphisms (r = 0.65).

CONCLUSIONS

These results suggest that higher 1,25OHD levels may be associated with better CKD stages in patients with type 2 diabetes and that this association was modified by FokI polymorphisms.

Authors+Show Affiliations

Division of Kidney, Hypertension, Department of Internal Medicine, Jikei University School of Medicine, Tokyo, Japan.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

23226566

Citation

Yokoyama, Keitaro, et al. "Interactions Between Serum Vitamin D Levels and Vitamin D Receptor Gene FokI Polymorphisms for Renal Function in Patients With Type 2 Diabetes." PloS One, vol. 7, no. 12, 2012, pp. e51171.
Yokoyama K, Nakashima A, Urashima M, et al. Interactions between serum vitamin D levels and vitamin D receptor gene FokI polymorphisms for renal function in patients with type 2 diabetes. PLoS One. 2012;7(12):e51171.
Yokoyama, K., Nakashima, A., Urashima, M., Suga, H., Mimura, T., Kimura, Y., Kanazawa, Y., Yokota, T., Sakamoto, M., Ishizawa, S., Nishimura, R., Kurata, H., Tanno, Y., Tojo, K., Kageyama, S., Ohkido, I., Utsunomiya, K., & Hosoya, T. (2012). Interactions between serum vitamin D levels and vitamin D receptor gene FokI polymorphisms for renal function in patients with type 2 diabetes. PloS One, 7(12), e51171. https://doi.org/10.1371/journal.pone.0051171
Yokoyama K, et al. Interactions Between Serum Vitamin D Levels and Vitamin D Receptor Gene FokI Polymorphisms for Renal Function in Patients With Type 2 Diabetes. PLoS One. 2012;7(12):e51171. PubMed PMID: 23226566.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Interactions between serum vitamin D levels and vitamin D receptor gene FokI polymorphisms for renal function in patients with type 2 diabetes. AU - Yokoyama,Keitaro, AU - Nakashima,Akio, AU - Urashima,Mitsuyoshi, AU - Suga,Hiroaki, AU - Mimura,Takeshi, AU - Kimura,Yasuo, AU - Kanazawa,Yasushi, AU - Yokota,Tamotsu, AU - Sakamoto,Masaya, AU - Ishizawa,Sho, AU - Nishimura,Rimei, AU - Kurata,Hideaki, AU - Tanno,Yudo, AU - Tojo,Katsuyoshi, AU - Kageyama,Shigeru, AU - Ohkido,Ichiro, AU - Utsunomiya,Kazunori, AU - Hosoya,Tatsuo, Y1 - 2012/12/04/ PY - 2012/07/27/received PY - 2012/10/30/accepted PY - 2012/12/11/entrez PY - 2012/12/12/pubmed PY - 2013/5/23/medline SP - e51171 EP - e51171 JF - PloS one JO - PLoS One VL - 7 IS - 12 N2 - BACKGROUND: We aimed to examine associations among serum 25-hydroxyvitamin D (25OHD) levels, 1,25-dihyroxyvitamin D (1,25OHD) levels, vitamin D receptor (VDR) polymorphisms, and renal function based on estimated glomerular filtration rate (eGFR) in patients with type 2 diabetes. METHODS: In a cross-sectional study of 410 patients, chronic kidney disease (CKD) stage assessed by eGFR was compared with 25OHD, 1,25OHD, and VDR FokI (rs10735810) polymorphisms by an ordered logistic regression model adjusted for the following confounders: disease duration, calendar month, use of angiotensin converting enzyme inhibitors/angiotensin receptor blockers or statins, and serum calcium, phosphate, and intact parathyroid hormone levels. RESULTS: 1,25OHD levels, rather than 25OHD levels, showed seasonal oscillations; peak levels were seen from May to October and the lowest levels were seen from December to February. These findings were evident in patients with CKD stage 3 ~ 5 but not stage 1 ~ 2. eGFR was in direct proportion to both 25OHD and 1,25OHD levels (P<0.0001), but it had stronger linearity with 1,25OHD (r = 0.73) than 25OHD (r = 0.22) levels. Using multivariate analysis, 1,25OHD levels (P<0.001), but not 25OHD levels, were negatively associated with CKD stage. Although FokI polymorphisms by themselves showed no significant associations with CKD stage, a significant interaction between 1,25OHD and FokITT was observed (P = 0.008). The positive association between 1,25OHD and eGFR was steeper in FokICT and CC polymorphisms (r = 0.74) than FokITT polymorphisms (r = 0.65). CONCLUSIONS: These results suggest that higher 1,25OHD levels may be associated with better CKD stages in patients with type 2 diabetes and that this association was modified by FokI polymorphisms. SN - 1932-6203 UR - https://www.unboundmedicine.com/medline/citation/23226566/Interactions_between_serum_vitamin_D_levels_and_vitamin_D_receptor_gene_FokI_polymorphisms_for_renal_function_in_patients_with_type_2_diabetes_ L2 - https://dx.plos.org/10.1371/journal.pone.0051171 DB - PRIME DP - Unbound Medicine ER -