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Hypomagnesemia in type 2 diabetes mellitus.

Abstract

INTRODUCTION

Hypomagnesemia is reported in type 2 diabetes; magnesium deficiency may play a role in the development of endothelial dysfunction and altered insulin function.

OBJECTIVE

To assess the incidence of hypomagnesemia among noncritically ill patients of Type 2 diabetes mellitus and to evaluate the relation of hypomagnesemia to glycemic control and various long-term complications of diabetes mellitus.

MATERIALS AND METHODS

One hundred and fifty, noncritically ill (APACHE score < 10) type 2 diabetes mellitus patients, who were admitted in the Departments of Medicine and Endocrinology, GMCH for uncontrolled hyperglycemia and/or various diabetic complications were studied. Serum magnesium was assessed at admission and rechecked in those found to be deficient.

RESULTS

Hypomagnesemia (Se magnesium < 1.6 mg/dl) was documented in 17 (11.33%) patients with a female:male ratio of 9:8. Mean HbA1c was 11.9% in the hypomagnesemic patients compared with 9.8% in controls (P =0.0016). Retinopathy, microalbuminuria, macroalbuminuria, foot ulceration, and neuropathy was present in 64%, 47%, 17.64%, 58.8%, and 82.35%, respectively, of the patients with hypomagnesemia as compared with 45.8% (P =0.118), 38.34% (P =0.704),15.03% (P =0.566), 22.55% (P =0.011) and 82.7% (P =0.976) without hypomagnesemia. Coronary artery disease was less common in the hypomagnesemia group (17.6% vs 39%), but comparable in the subgroup < 50 years (27% vs 25%) (P =0.796).

CONCLUSION

Hypomagnesemia in diabetes was associated with poorer glycemic control, retinopathy, nephropathy, and foot ulcers.

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  • Authors+Show Affiliations

    ,

    Department of Endocrinology and Metabolism, Gauhati Medical College and Hospital, Guwahati, Assam, India.

    ,

    Source

    Pub Type(s)

    Journal Article

    Language

    eng

    PubMed ID

    23226651

    Citation

    Dasgupta, Arundhati, et al. "Hypomagnesemia in Type 2 Diabetes Mellitus." Indian Journal of Endocrinology and Metabolism, vol. 16, no. 6, 2012, pp. 1000-3.
    Dasgupta A, Sarma D, Saikia UK. Hypomagnesemia in type 2 diabetes mellitus. Indian J Endocrinol Metab. 2012;16(6):1000-3.
    Dasgupta, A., Sarma, D., & Saikia, U. K. (2012). Hypomagnesemia in type 2 diabetes mellitus. Indian Journal of Endocrinology and Metabolism, 16(6), pp. 1000-3. doi:10.4103/2230-8210.103020.
    Dasgupta A, Sarma D, Saikia UK. Hypomagnesemia in Type 2 Diabetes Mellitus. Indian J Endocrinol Metab. 2012;16(6):1000-3. PubMed PMID: 23226651.
    * Article titles in AMA citation format should be in sentence-case
    TY - JOUR T1 - Hypomagnesemia in type 2 diabetes mellitus. AU - Dasgupta,Arundhati, AU - Sarma,Dipti, AU - Saikia,Uma Kaimal, PY - 2012/12/11/entrez PY - 2012/12/12/pubmed PY - 2012/12/12/medline KW - Diabetic complications KW - glycemic control KW - hypomagnesemia KW - type 2 diabetes SP - 1000 EP - 3 JF - Indian journal of endocrinology and metabolism JO - Indian J Endocrinol Metab VL - 16 IS - 6 N2 - INTRODUCTION: Hypomagnesemia is reported in type 2 diabetes; magnesium deficiency may play a role in the development of endothelial dysfunction and altered insulin function. OBJECTIVE: To assess the incidence of hypomagnesemia among noncritically ill patients of Type 2 diabetes mellitus and to evaluate the relation of hypomagnesemia to glycemic control and various long-term complications of diabetes mellitus. MATERIALS AND METHODS: One hundred and fifty, noncritically ill (APACHE score < 10) type 2 diabetes mellitus patients, who were admitted in the Departments of Medicine and Endocrinology, GMCH for uncontrolled hyperglycemia and/or various diabetic complications were studied. Serum magnesium was assessed at admission and rechecked in those found to be deficient. RESULTS: Hypomagnesemia (Se magnesium < 1.6 mg/dl) was documented in 17 (11.33%) patients with a female:male ratio of 9:8. Mean HbA1c was 11.9% in the hypomagnesemic patients compared with 9.8% in controls (P =0.0016). Retinopathy, microalbuminuria, macroalbuminuria, foot ulceration, and neuropathy was present in 64%, 47%, 17.64%, 58.8%, and 82.35%, respectively, of the patients with hypomagnesemia as compared with 45.8% (P =0.118), 38.34% (P =0.704),15.03% (P =0.566), 22.55% (P =0.011) and 82.7% (P =0.976) without hypomagnesemia. Coronary artery disease was less common in the hypomagnesemia group (17.6% vs 39%), but comparable in the subgroup < 50 years (27% vs 25%) (P =0.796). CONCLUSION: Hypomagnesemia in diabetes was associated with poorer glycemic control, retinopathy, nephropathy, and foot ulcers. SN - 2230-8210 UR - https://www.unboundmedicine.com/medline/citation/23226651/Hypomagnesemia_in_type_2_diabetes_mellitus_ L2 - http://www.ijem.in/article.asp?issn=2230-8210;year=2012;volume=16;issue=6;spage=1000;epage=1003;aulast=Dasgupta DB - PRIME DP - Unbound Medicine ER -