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Hypomagnesemia in type 2 diabetes mellitus.
Indian J Endocrinol Metab 2012; 16(6):1000-3IJ

Abstract

INTRODUCTION

Hypomagnesemia is reported in type 2 diabetes; magnesium deficiency may play a role in the development of endothelial dysfunction and altered insulin function.

OBJECTIVE

To assess the incidence of hypomagnesemia among noncritically ill patients of Type 2 diabetes mellitus and to evaluate the relation of hypomagnesemia to glycemic control and various long-term complications of diabetes mellitus.

MATERIALS AND METHODS

One hundred and fifty, noncritically ill (APACHE score < 10) type 2 diabetes mellitus patients, who were admitted in the Departments of Medicine and Endocrinology, GMCH for uncontrolled hyperglycemia and/or various diabetic complications were studied. Serum magnesium was assessed at admission and rechecked in those found to be deficient.

RESULTS

Hypomagnesemia (Se magnesium < 1.6 mg/dl) was documented in 17 (11.33%) patients with a female:male ratio of 9:8. Mean HbA1c was 11.9% in the hypomagnesemic patients compared with 9.8% in controls (P =0.0016). Retinopathy, microalbuminuria, macroalbuminuria, foot ulceration, and neuropathy was present in 64%, 47%, 17.64%, 58.8%, and 82.35%, respectively, of the patients with hypomagnesemia as compared with 45.8% (P =0.118), 38.34% (P =0.704),15.03% (P =0.566), 22.55% (P =0.011) and 82.7% (P =0.976) without hypomagnesemia. Coronary artery disease was less common in the hypomagnesemia group (17.6% vs 39%), but comparable in the subgroup < 50 years (27% vs 25%) (P =0.796).

CONCLUSION

Hypomagnesemia in diabetes was associated with poorer glycemic control, retinopathy, nephropathy, and foot ulcers.

Authors+Show Affiliations

Department of Endocrinology and Metabolism, Gauhati Medical College and Hospital, Guwahati, Assam, India.No affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

23226651

Citation

Dasgupta, Arundhati, et al. "Hypomagnesemia in Type 2 Diabetes Mellitus." Indian Journal of Endocrinology and Metabolism, vol. 16, no. 6, 2012, pp. 1000-3.
Dasgupta A, Sarma D, Saikia UK. Hypomagnesemia in type 2 diabetes mellitus. Indian J Endocrinol Metab. 2012;16(6):1000-3.
Dasgupta, A., Sarma, D., & Saikia, U. K. (2012). Hypomagnesemia in type 2 diabetes mellitus. Indian Journal of Endocrinology and Metabolism, 16(6), pp. 1000-3. doi:10.4103/2230-8210.103020.
Dasgupta A, Sarma D, Saikia UK. Hypomagnesemia in Type 2 Diabetes Mellitus. Indian J Endocrinol Metab. 2012;16(6):1000-3. PubMed PMID: 23226651.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Hypomagnesemia in type 2 diabetes mellitus. AU - Dasgupta,Arundhati, AU - Sarma,Dipti, AU - Saikia,Uma Kaimal, PY - 2012/12/11/entrez PY - 2012/12/12/pubmed PY - 2012/12/12/medline KW - Diabetic complications KW - glycemic control KW - hypomagnesemia KW - type 2 diabetes SP - 1000 EP - 3 JF - Indian journal of endocrinology and metabolism JO - Indian J Endocrinol Metab VL - 16 IS - 6 N2 - INTRODUCTION: Hypomagnesemia is reported in type 2 diabetes; magnesium deficiency may play a role in the development of endothelial dysfunction and altered insulin function. OBJECTIVE: To assess the incidence of hypomagnesemia among noncritically ill patients of Type 2 diabetes mellitus and to evaluate the relation of hypomagnesemia to glycemic control and various long-term complications of diabetes mellitus. MATERIALS AND METHODS: One hundred and fifty, noncritically ill (APACHE score < 10) type 2 diabetes mellitus patients, who were admitted in the Departments of Medicine and Endocrinology, GMCH for uncontrolled hyperglycemia and/or various diabetic complications were studied. Serum magnesium was assessed at admission and rechecked in those found to be deficient. RESULTS: Hypomagnesemia (Se magnesium < 1.6 mg/dl) was documented in 17 (11.33%) patients with a female:male ratio of 9:8. Mean HbA1c was 11.9% in the hypomagnesemic patients compared with 9.8% in controls (P =0.0016). Retinopathy, microalbuminuria, macroalbuminuria, foot ulceration, and neuropathy was present in 64%, 47%, 17.64%, 58.8%, and 82.35%, respectively, of the patients with hypomagnesemia as compared with 45.8% (P =0.118), 38.34% (P =0.704),15.03% (P =0.566), 22.55% (P =0.011) and 82.7% (P =0.976) without hypomagnesemia. Coronary artery disease was less common in the hypomagnesemia group (17.6% vs 39%), but comparable in the subgroup < 50 years (27% vs 25%) (P =0.796). CONCLUSION: Hypomagnesemia in diabetes was associated with poorer glycemic control, retinopathy, nephropathy, and foot ulcers. SN - 2230-8210 UR - https://www.unboundmedicine.com/medline/citation/23226651/Hypomagnesemia_in_type_2_diabetes_mellitus_ L2 - http://www.ijem.in/article.asp?issn=2230-8210;year=2012;volume=16;issue=6;spage=1000;epage=1003;aulast=Dasgupta DB - PRIME DP - Unbound Medicine ER -