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Association of homocysteine levels with blood lead levels and micronutrients in the US general population.
J Prev Med Public Health. 2012 Nov; 45(6):387-93.JP

Abstract

OBJECTIVES

Even though several epidemiological studies have observed positive associations between blood lead levels and homocysteine, no study has examined whether this association differs by the levels of micronutrients, such as folate, vitamin B6, and vitamin B12, which are involved in the metabolism of homocysteine. In this study, we examined the interactions between micronutrients and blood lead on homocysteine levels.

METHODS

This study was performed with 4089 adults aged ≥20 years old in the US general population using the National Health and Nutrition Examination Survey 2003-2004.

RESULTS

There were significant or marginally significant interactions between micronutrients and blood lead levels on mean homocysteine levels. Positive associations between blood lead and homocysteine were clearly observed among subjects with low levels of folate or low vitamin B6 (p-trend <0.01, respectively). However, in the case of vitamin B12, there was a stronger positive association between blood lead and homocysteine among subjects with high levels of vitamin B12, compared to those with low levels of vitamin B12. In fact, the levels of homocysteine were already high among subjects low in vitamin B12, irrespective of blood lead levels. When we used hyperhomocysteinemia (homocysteine>15 µmol/L) as the outcome, there were similar patterns of interaction, though p-values for each interaction failed to reach statistical significance.

CONCLUSIONS

In the current study, the association between blood lead and homocysteine differed based on the levels of folate, vitamin B6, or vitamin B12 present in the blood. It may be important to keep sufficient levels of these micronutrients to prevent the possible harmful effects of lead exposure on homocysteine levels.

Authors+Show Affiliations

Department of Preventive Medicine, Kyungpook National University School of Medicine, Daegu, Korea.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

23230469

Citation

Lee, Yu-Mi, et al. "Association of Homocysteine Levels With Blood Lead Levels and Micronutrients in the US General Population." Journal of Preventive Medicine and Public Health = Yebang Uihakhoe Chi, vol. 45, no. 6, 2012, pp. 387-93.
Lee YM, Lee MK, Bae SG, et al. Association of homocysteine levels with blood lead levels and micronutrients in the US general population. J Prev Med Public Health. 2012;45(6):387-93.
Lee, Y. M., Lee, M. K., Bae, S. G., Lee, S. H., Kim, S. Y., & Lee, D. H. (2012). Association of homocysteine levels with blood lead levels and micronutrients in the US general population. Journal of Preventive Medicine and Public Health = Yebang Uihakhoe Chi, 45(6), 387-93. https://doi.org/10.3961/jpmph.2012.45.6.387
Lee YM, et al. Association of Homocysteine Levels With Blood Lead Levels and Micronutrients in the US General Population. J Prev Med Public Health. 2012;45(6):387-93. PubMed PMID: 23230469.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Association of homocysteine levels with blood lead levels and micronutrients in the US general population. AU - Lee,Yu-Mi, AU - Lee,Mi-Kyung, AU - Bae,Sang-Geun, AU - Lee,Seon-Hwa, AU - Kim,Sun-Young, AU - Lee,Duk-Hee, Y1 - 2012/11/29/ PY - 2012/06/30/received PY - 2012/10/10/accepted PY - 2012/12/12/entrez PY - 2012/12/12/pubmed PY - 2013/11/15/medline KW - Folic acid KW - Homocysteine KW - Lead KW - Vitamin B12 KW - Vitamin B6 SP - 387 EP - 93 JF - Journal of preventive medicine and public health = Yebang Uihakhoe chi JO - J Prev Med Public Health VL - 45 IS - 6 N2 - OBJECTIVES: Even though several epidemiological studies have observed positive associations between blood lead levels and homocysteine, no study has examined whether this association differs by the levels of micronutrients, such as folate, vitamin B6, and vitamin B12, which are involved in the metabolism of homocysteine. In this study, we examined the interactions between micronutrients and blood lead on homocysteine levels. METHODS: This study was performed with 4089 adults aged ≥20 years old in the US general population using the National Health and Nutrition Examination Survey 2003-2004. RESULTS: There were significant or marginally significant interactions between micronutrients and blood lead levels on mean homocysteine levels. Positive associations between blood lead and homocysteine were clearly observed among subjects with low levels of folate or low vitamin B6 (p-trend <0.01, respectively). However, in the case of vitamin B12, there was a stronger positive association between blood lead and homocysteine among subjects with high levels of vitamin B12, compared to those with low levels of vitamin B12. In fact, the levels of homocysteine were already high among subjects low in vitamin B12, irrespective of blood lead levels. When we used hyperhomocysteinemia (homocysteine>15 µmol/L) as the outcome, there were similar patterns of interaction, though p-values for each interaction failed to reach statistical significance. CONCLUSIONS: In the current study, the association between blood lead and homocysteine differed based on the levels of folate, vitamin B6, or vitamin B12 present in the blood. It may be important to keep sufficient levels of these micronutrients to prevent the possible harmful effects of lead exposure on homocysteine levels. SN - 2233-4521 UR - https://www.unboundmedicine.com/medline/citation/23230469/Association_of_homocysteine_levels_with_blood_lead_levels_and_micronutrients_in_the_US_general_population_ L2 - https://dx.doi.org/10.3961/jpmph.2012.45.6.387 DB - PRIME DP - Unbound Medicine ER -