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DJ-1 isoforms in whole blood as potential biomarkers of Parkinson disease.
Sci Rep. 2012; 2:954.SR

Abstract

DJ-1 is a multifunctional protein that plays an important role in oxidative stress, cell death, and synucleinopathies, including Parkinson disease. Previous studies have demonstrated that total DJ-1 levels decrease in the cerebrospinal fluid, but do not change significantly in human plasma from patients with Parkinson disease when compared with controls. In this study, we measured total DJ-1 and its isoforms in whole blood of patients with Parkinson disease at various stages, Alzheimer disease, and healthy controls to identify potential peripheral biomarkers of PD. In an initial discovery study of 119 subjects, 7 DJ-1 isoforms were reliably detected, and blood levels of those with 4-hydroxy-2-nonenal modifications were discovered to be altered in late-stage Parkinson disease. This result was further confirmed in a validation study of another 114 participants, suggesting that, unlike total DJ-1 levels, post-translationally modified isoforms of DJ-1 from whole blood are candidate biomarkers of late-stage Parkinson disease.

Authors+Show Affiliations

Department of Pathology, University of Washington School of Medicine , Seattle, WA, USA.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, Non-P.H.S.

Language

eng

PubMed ID

23233873

Citation

Lin, Xiangmin, et al. "DJ-1 Isoforms in Whole Blood as Potential Biomarkers of Parkinson Disease." Scientific Reports, vol. 2, 2012, p. 954.
Lin X, Cook TJ, Zabetian CP, et al. DJ-1 isoforms in whole blood as potential biomarkers of Parkinson disease. Sci Rep. 2012;2:954.
Lin, X., Cook, T. J., Zabetian, C. P., Leverenz, J. B., Peskind, E. R., Hu, S. C., Cain, K. C., Pan, C., Edgar, J. S., Goodlett, D. R., Racette, B. A., Checkoway, H., Montine, T. J., Shi, M., & Zhang, J. (2012). DJ-1 isoforms in whole blood as potential biomarkers of Parkinson disease. Scientific Reports, 2, 954. https://doi.org/10.1038/srep00954
Lin X, et al. DJ-1 Isoforms in Whole Blood as Potential Biomarkers of Parkinson Disease. Sci Rep. 2012;2:954. PubMed PMID: 23233873.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - DJ-1 isoforms in whole blood as potential biomarkers of Parkinson disease. AU - Lin,Xiangmin, AU - Cook,Travis J, AU - Zabetian,Cyrus P, AU - Leverenz,James B, AU - Peskind,Elaine R, AU - Hu,Shu-Ching, AU - Cain,Kevin C, AU - Pan,Catherine, AU - Edgar,John Scott, AU - Goodlett,David R, AU - Racette,Brad A, AU - Checkoway,Harvey, AU - Montine,Thomas J, AU - Shi,Min, AU - Zhang,Jing, Y1 - 2012/12/11/ PY - 2012/07/17/received PY - 2012/10/26/accepted PY - 2012/12/13/entrez PY - 2012/12/13/pubmed PY - 2013/5/29/medline SP - 954 EP - 954 JF - Scientific reports JO - Sci Rep VL - 2 N2 - DJ-1 is a multifunctional protein that plays an important role in oxidative stress, cell death, and synucleinopathies, including Parkinson disease. Previous studies have demonstrated that total DJ-1 levels decrease in the cerebrospinal fluid, but do not change significantly in human plasma from patients with Parkinson disease when compared with controls. In this study, we measured total DJ-1 and its isoforms in whole blood of patients with Parkinson disease at various stages, Alzheimer disease, and healthy controls to identify potential peripheral biomarkers of PD. In an initial discovery study of 119 subjects, 7 DJ-1 isoforms were reliably detected, and blood levels of those with 4-hydroxy-2-nonenal modifications were discovered to be altered in late-stage Parkinson disease. This result was further confirmed in a validation study of another 114 participants, suggesting that, unlike total DJ-1 levels, post-translationally modified isoforms of DJ-1 from whole blood are candidate biomarkers of late-stage Parkinson disease. SN - 2045-2322 UR - https://www.unboundmedicine.com/medline/citation/23233873/DJ_1_isoforms_in_whole_blood_as_potential_biomarkers_of_Parkinson_disease_ L2 - https://doi.org/10.1038/srep00954 DB - PRIME DP - Unbound Medicine ER -