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Retrospective analysis of risk factors for central nervous system metastases in operable breast cancer: effects of biologic subtype and Ki67 overexpression on survival.
Oncology. 2013; 84(3):135-40.O

Abstract

OBJECTIVE

Identifying factors that predispose patients to central nervous system (CNS) metastases may hasten disease detection and improve treatment outcomes.

METHODS

We reviewed the records of patients who were diagnosed with clinical stage I-III primary breast cancer at the National Cancer Center Hospital East from 2003 to 2005. Cox proportional hazard models were fitted to reveal risk factors for CNS metastases.

RESULTS

The median follow-up period after the operation was 53.5 months. Among the 591 identified patients with breast cancer, 76 experienced a relapse. Seventeen patients developed CNS metastases. Multivariate analysis indicated that the triple negative (TN) subtype (hazard ratio = 5.5) and a high Ki67 labeling index (LI; hazard ratio = 3.9) were associated with a higher risk for CNS metastases. At 4 years, the TN subtype was associated with significantly worse overall and disease-free survival rates and a higher cumulative incidence of CNS metastases compared with hormone receptor-positive/ human epidermal growth factor receptor-2-negative tumors. Breast cancers with a Ki67 LI ≥30% were also associated with lower overall and disease-free survival rates and a higher cumulative incidence of CNS metastases compared with cancers with a Ki67 LI <30%.

CONCLUSION

TN or Ki67-overexpressing breast cancer produced earlier CNS metastases and lower disease-free and overall survival rates.

Authors+Show Affiliations

Divisions of Oncology/Hematology, National Cancer Center Hospital East, Kashiwa, Japan. mishihara @ clin.medic.mie-u.ac.jpNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

23235554

Citation

Ishihara, Mikiya, et al. "Retrospective Analysis of Risk Factors for Central Nervous System Metastases in Operable Breast Cancer: Effects of Biologic Subtype and Ki67 Overexpression On Survival." Oncology, vol. 84, no. 3, 2013, pp. 135-40.
Ishihara M, Mukai H, Nagai S, et al. Retrospective analysis of risk factors for central nervous system metastases in operable breast cancer: effects of biologic subtype and Ki67 overexpression on survival. Oncology. 2013;84(3):135-40.
Ishihara, M., Mukai, H., Nagai, S., Onozawa, M., Nihei, K., Shimada, T., & Wada, N. (2013). Retrospective analysis of risk factors for central nervous system metastases in operable breast cancer: effects of biologic subtype and Ki67 overexpression on survival. Oncology, 84(3), 135-40. https://doi.org/10.1159/000345321
Ishihara M, et al. Retrospective Analysis of Risk Factors for Central Nervous System Metastases in Operable Breast Cancer: Effects of Biologic Subtype and Ki67 Overexpression On Survival. Oncology. 2013;84(3):135-40. PubMed PMID: 23235554.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Retrospective analysis of risk factors for central nervous system metastases in operable breast cancer: effects of biologic subtype and Ki67 overexpression on survival. AU - Ishihara,Mikiya, AU - Mukai,Hirofumi, AU - Nagai,Shunji, AU - Onozawa,Masakatsu, AU - Nihei,Keiji, AU - Shimada,Toshiyuki, AU - Wada,Noriaki, Y1 - 2012/12/11/ PY - 2012/07/23/received PY - 2012/10/15/accepted PY - 2012/12/14/entrez PY - 2012/12/14/pubmed PY - 2013/3/21/medline SP - 135 EP - 40 JF - Oncology JO - Oncology VL - 84 IS - 3 N2 - OBJECTIVE: Identifying factors that predispose patients to central nervous system (CNS) metastases may hasten disease detection and improve treatment outcomes. METHODS: We reviewed the records of patients who were diagnosed with clinical stage I-III primary breast cancer at the National Cancer Center Hospital East from 2003 to 2005. Cox proportional hazard models were fitted to reveal risk factors for CNS metastases. RESULTS: The median follow-up period after the operation was 53.5 months. Among the 591 identified patients with breast cancer, 76 experienced a relapse. Seventeen patients developed CNS metastases. Multivariate analysis indicated that the triple negative (TN) subtype (hazard ratio = 5.5) and a high Ki67 labeling index (LI; hazard ratio = 3.9) were associated with a higher risk for CNS metastases. At 4 years, the TN subtype was associated with significantly worse overall and disease-free survival rates and a higher cumulative incidence of CNS metastases compared with hormone receptor-positive/ human epidermal growth factor receptor-2-negative tumors. Breast cancers with a Ki67 LI ≥30% were also associated with lower overall and disease-free survival rates and a higher cumulative incidence of CNS metastases compared with cancers with a Ki67 LI <30%. CONCLUSION: TN or Ki67-overexpressing breast cancer produced earlier CNS metastases and lower disease-free and overall survival rates. SN - 1423-0232 UR - https://www.unboundmedicine.com/medline/citation/23235554/Retrospective_analysis_of_risk_factors_for_central_nervous_system_metastases_in_operable_breast_cancer:_effects_of_biologic_subtype_and_Ki67_overexpression_on_survival_ L2 - https://www.karger.com?DOI=10.1159/000345321 DB - PRIME DP - Unbound Medicine ER -