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Fruits and vegetables consumption and risk of non-Hodgkin's lymphoma: a meta-analysis of observational studies.

Abstract

Epidemiologic evidence suggests that intakes of fruits and/or vegetables may play a role in the etiology of non-Hodgkin's lymphoma (NHL), but the findings are inconsistent. We aimed to assess fruits and/or vegetables intakes in relation to risk of NHL by a meta-analytic approach. We searched on PubMed database from January 1966 to September 2012 to indentify case-control and cohort studies. We used a random-effects model to compute summary risk estimates. For vegetables, the summary relative risks (RRs) of NHL for high versus low intake for case-control, cohort and all studies were 0.75 (95% CI, 0.60-0.94; N = 8), 0.90 (95% CI, 0.81-1.00; N = 5) and 0.81 (95%CI, 0.71-0.92; N = 13) ; and the corresponding RRs for intake of 1 serving per day were 0.88 (95% CI, 0.80-0.96; N = 8), 0.96 (95% CI, 0.92-1.00; N = 5) and 0.92 (95%CI, 0.87-0.96; N = 13). For fruits and vegetables combined, the summary RR for high versus low intake was 0.78 (95%CI, 0.66-0.92; N = 4), and for intake of 1 serving per day was 0.95 (95%CI, 0.91-1.00; N = 4). Regarding histological subtypes, vegetables intake was significantly inversely associated with diffuse large B-cell lymphoma and follicular lymphoma, but not small lymphocytic lymphoma/chronic lymphocytic leukemia (high vs. low intake, RR = 0.70, 0.70 and 1.01, respectively; N = 7, 7 and 10, respectively). Fruits intake was generally not associated with total NHL, or any histological subtypes. Our findings suggest that intakes of vegetables, and fruits and vegetables combined, but not fruits alone, significantly reduce risk of NHL.

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  • Authors+Show Affiliations

    ,

    Department of Epidemiology, School of Public Health, Soochow University, China.

    , ,

    Source

    International journal of cancer 133:1 2013 Jul pg 190-200

    MeSH

    Adult
    Aged
    Case-Control Studies
    Cohort Studies
    Europe
    Feeding Behavior
    Female
    Fruit
    Humans
    Leukemia, Lymphocytic, Chronic, B-Cell
    Lymphoma, Follicular
    Lymphoma, Large B-Cell, Diffuse
    Lymphoma, Non-Hodgkin
    Male
    Middle Aged
    North America
    Odds Ratio
    Risk Assessment
    Risk Factors
    Surveys and Questionnaires
    Vegetables

    Pub Type(s)

    Journal Article
    Meta-Analysis
    Research Support, Non-U.S. Gov't

    Language

    eng

    PubMed ID

    23238796

    Citation

    Chen, Guo-Chong, et al. "Fruits and Vegetables Consumption and Risk of non-Hodgkin's Lymphoma: a Meta-analysis of Observational Studies." International Journal of Cancer, vol. 133, no. 1, 2013, pp. 190-200.
    Chen GC, Lv DB, Pang Z, et al. Fruits and vegetables consumption and risk of non-Hodgkin's lymphoma: a meta-analysis of observational studies. Int J Cancer. 2013;133(1):190-200.
    Chen, G. C., Lv, D. B., Pang, Z., & Liu, Q. F. (2013). Fruits and vegetables consumption and risk of non-Hodgkin's lymphoma: a meta-analysis of observational studies. International Journal of Cancer, 133(1), pp. 190-200. doi:10.1002/ijc.27992.
    Chen GC, et al. Fruits and Vegetables Consumption and Risk of non-Hodgkin's Lymphoma: a Meta-analysis of Observational Studies. Int J Cancer. 2013;133(1):190-200. PubMed PMID: 23238796.
    * Article titles in AMA citation format should be in sentence-case
    TY - JOUR T1 - Fruits and vegetables consumption and risk of non-Hodgkin's lymphoma: a meta-analysis of observational studies. AU - Chen,Guo-Chong, AU - Lv,Da-Bing, AU - Pang,Zhi, AU - Liu,Qing-Fang, Y1 - 2013/01/18/ PY - 2012/08/06/received PY - 2012/11/12/accepted PY - 2012/12/15/entrez PY - 2012/12/15/pubmed PY - 2013/6/12/medline SP - 190 EP - 200 JF - International journal of cancer JO - Int. J. Cancer VL - 133 IS - 1 N2 - Epidemiologic evidence suggests that intakes of fruits and/or vegetables may play a role in the etiology of non-Hodgkin's lymphoma (NHL), but the findings are inconsistent. We aimed to assess fruits and/or vegetables intakes in relation to risk of NHL by a meta-analytic approach. We searched on PubMed database from January 1966 to September 2012 to indentify case-control and cohort studies. We used a random-effects model to compute summary risk estimates. For vegetables, the summary relative risks (RRs) of NHL for high versus low intake for case-control, cohort and all studies were 0.75 (95% CI, 0.60-0.94; N = 8), 0.90 (95% CI, 0.81-1.00; N = 5) and 0.81 (95%CI, 0.71-0.92; N = 13) ; and the corresponding RRs for intake of 1 serving per day were 0.88 (95% CI, 0.80-0.96; N = 8), 0.96 (95% CI, 0.92-1.00; N = 5) and 0.92 (95%CI, 0.87-0.96; N = 13). For fruits and vegetables combined, the summary RR for high versus low intake was 0.78 (95%CI, 0.66-0.92; N = 4), and for intake of 1 serving per day was 0.95 (95%CI, 0.91-1.00; N = 4). Regarding histological subtypes, vegetables intake was significantly inversely associated with diffuse large B-cell lymphoma and follicular lymphoma, but not small lymphocytic lymphoma/chronic lymphocytic leukemia (high vs. low intake, RR = 0.70, 0.70 and 1.01, respectively; N = 7, 7 and 10, respectively). Fruits intake was generally not associated with total NHL, or any histological subtypes. Our findings suggest that intakes of vegetables, and fruits and vegetables combined, but not fruits alone, significantly reduce risk of NHL. SN - 1097-0215 UR - https://www.unboundmedicine.com/medline/citation/23238796/Fruits_and_vegetables_consumption_and_risk_of_non_Hodgkin's_lymphoma:_a_meta_analysis_of_observational_studies_ L2 - https://doi.org/10.1002/ijc.27992 DB - PRIME DP - Unbound Medicine ER -