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Diabetes as an independent predictor of high atherosclerotic burden assessed by coronary computed tomography angiography: the coronary artery disease equivalent revisited.
Int J Cardiovasc Imaging. 2013 Jun; 29(5):1105-14.IJ

Abstract

(1) To study the prevalence and severity of coronary artery disease (CAD) in diabetic patients. (2) To provide a detailed characterization of the coronary atherosclerotic burden, including the localization, degree of stenosis and plaque composition by coronary computed tomography angiography (CCTA). Single center prospective registry including a total of 581 consecutive stable patients (April 2011-March 2012) undergoing CCTA (Dual-source CT) for the evaluation of suspected CAD without previous myocardial infarction or revascularization procedures. Different coronary plaque burden indexes and plaque type and distribution patterns were compared between patients with (n = 85) and without diabetes (n = 496). The prevalence of CAD (any plaque; 74.1 vs. 56%; p = 0.002) and obstructive CAD (≥50% stenosis; 31.8 vs. 10.3%; p < 0.001) were significantly higher in diabetic patients. The remaining coronary atherosclerotic burden indexes evaluated (plaque in LM-3v-2v with prox. LAD; SIS; SSS; CT-LeSc) were also significantly higher in diabetic patients. In the per segment analysis, diabetics had a higher percentage of segments with plaque in every vessel (2.6/13.1/7.5/10.5% for diabetics vs. 1.4/7.1/3.3/4.4% for nondiabetics for LM, LAD, LCx, RCA respectively; p < 0.001 for all) and of both calcified (19.3 vs. 9.2%, p < 0.001) and noncalcified or mixed types (14.4 vs. 7.0%; p < 0.001); the ratio of proximal-to-distal relative plaque distribution (calculated as LM/proximal vs. mid/distal/branches) was lower for diabetics (0.75 vs. 1.04; p = 0.009). Diabetes was an independent predictor of CAD and was also associated with more advanced CAD, evaluated by indexes of coronary atherosclerotic burden. Diabetics had a significantly higher prevalence of plaques in every anatomical subset and for the different plaque composition. In this report, the relative geographic distribution of the plaques within each subgroup, favored a more mid-to-distal localization in the diabetic patients.

Authors+Show Affiliations

Cardiology Department, Centro Hospitalar Lisboa Ocidental, Av. Prof. Reinaldo dos Santos, 2790-134 Carnaxide, Lisbon, Portugal. paraujogoncalves@yahoo.co.ukNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

23239217

Citation

de Araújo Gonçalves, Pedro, et al. "Diabetes as an Independent Predictor of High Atherosclerotic Burden Assessed By Coronary Computed Tomography Angiography: the Coronary Artery Disease Equivalent Revisited." The International Journal of Cardiovascular Imaging, vol. 29, no. 5, 2013, pp. 1105-14.
de Araújo Gonçalves P, Garcia-Garcia HM, Carvalho MS, et al. Diabetes as an independent predictor of high atherosclerotic burden assessed by coronary computed tomography angiography: the coronary artery disease equivalent revisited. Int J Cardiovasc Imaging. 2013;29(5):1105-14.
de Araújo Gonçalves, P., Garcia-Garcia, H. M., Carvalho, M. S., Dores, H., Sousa, P. J., Marques, H., Ferreira, A., Cardim, N., Teles, R. C., Raposo, L., Gabriel, H. M., Almeida, M., Aleixo, A., Carmo, M. M., Machado, F. P., & Mendes, M. (2013). Diabetes as an independent predictor of high atherosclerotic burden assessed by coronary computed tomography angiography: the coronary artery disease equivalent revisited. The International Journal of Cardiovascular Imaging, 29(5), 1105-14. https://doi.org/10.1007/s10554-012-0168-4
de Araújo Gonçalves P, et al. Diabetes as an Independent Predictor of High Atherosclerotic Burden Assessed By Coronary Computed Tomography Angiography: the Coronary Artery Disease Equivalent Revisited. Int J Cardiovasc Imaging. 2013;29(5):1105-14. PubMed PMID: 23239217.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Diabetes as an independent predictor of high atherosclerotic burden assessed by coronary computed tomography angiography: the coronary artery disease equivalent revisited. AU - de Araújo Gonçalves,Pedro, AU - Garcia-Garcia,Hector M, AU - Carvalho,Maria Salomé, AU - Dores,Helder, AU - Sousa,Pedro Jeronimo, AU - Marques,Hugo, AU - Ferreira,Antonio, AU - Cardim,Nuno, AU - Teles,Rui Campante, AU - Raposo,Luís, AU - Gabriel,Henrique Mesquita, AU - Almeida,Manuel, AU - Aleixo,Ana, AU - Carmo,Miguel Mota, AU - Machado,Francisco Pereira, AU - Mendes,Miguel, Y1 - 2012/12/13/ PY - 2012/10/10/received PY - 2012/12/05/accepted PY - 2012/12/15/entrez PY - 2012/12/15/pubmed PY - 2014/2/8/medline SP - 1105 EP - 14 JF - The international journal of cardiovascular imaging JO - Int J Cardiovasc Imaging VL - 29 IS - 5 N2 - (1) To study the prevalence and severity of coronary artery disease (CAD) in diabetic patients. (2) To provide a detailed characterization of the coronary atherosclerotic burden, including the localization, degree of stenosis and plaque composition by coronary computed tomography angiography (CCTA). Single center prospective registry including a total of 581 consecutive stable patients (April 2011-March 2012) undergoing CCTA (Dual-source CT) for the evaluation of suspected CAD without previous myocardial infarction or revascularization procedures. Different coronary plaque burden indexes and plaque type and distribution patterns were compared between patients with (n = 85) and without diabetes (n = 496). The prevalence of CAD (any plaque; 74.1 vs. 56%; p = 0.002) and obstructive CAD (≥50% stenosis; 31.8 vs. 10.3%; p < 0.001) were significantly higher in diabetic patients. The remaining coronary atherosclerotic burden indexes evaluated (plaque in LM-3v-2v with prox. LAD; SIS; SSS; CT-LeSc) were also significantly higher in diabetic patients. In the per segment analysis, diabetics had a higher percentage of segments with plaque in every vessel (2.6/13.1/7.5/10.5% for diabetics vs. 1.4/7.1/3.3/4.4% for nondiabetics for LM, LAD, LCx, RCA respectively; p < 0.001 for all) and of both calcified (19.3 vs. 9.2%, p < 0.001) and noncalcified or mixed types (14.4 vs. 7.0%; p < 0.001); the ratio of proximal-to-distal relative plaque distribution (calculated as LM/proximal vs. mid/distal/branches) was lower for diabetics (0.75 vs. 1.04; p = 0.009). Diabetes was an independent predictor of CAD and was also associated with more advanced CAD, evaluated by indexes of coronary atherosclerotic burden. Diabetics had a significantly higher prevalence of plaques in every anatomical subset and for the different plaque composition. In this report, the relative geographic distribution of the plaques within each subgroup, favored a more mid-to-distal localization in the diabetic patients. SN - 1875-8312 UR - https://www.unboundmedicine.com/medline/citation/23239217/Diabetes_as_an_independent_predictor_of_high_atherosclerotic_burden_assessed_by_coronary_computed_tomography_angiography:_the_coronary_artery_disease_equivalent_revisited_ L2 - https://doi.org/10.1007/s10554-012-0168-4 DB - PRIME DP - Unbound Medicine ER -