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Elimination disorders in persons with Prader-Willi and Fragile-X syndromes.
Neurourol Urodyn. 2013 Sep; 32(7):986-92.NU

Abstract

AIMS

Elimination disorders are common in typically developing children. Only few studies have addressed elimination disorders in persons with intellectual disability (ID)-and even fewer studies in those with specific syndromes. The aim of the study was to investigate the rates of elimination disorders and behavioral symptoms in persons with Prader-Willi (PWS) and Fragile-X syndromes (FXS) in a large sample.

METHODS

Three hundred fifty-seven persons with PWS or FXS were recruited through parent self-help groups. A questionnaire regarding elimination symptoms, as well as the child behavior checklist (CBCL)/young adult behavior checklist (YABCL) were filled out by parents or caregivers.

RESULTS

The sample included 191 persons with PWS (54.5% male) with a mean age of 20.0 years and 166 persons with FXS (92.2% male) with a mean age of 15.4 years. Persons with FXS were significantly more often affected by elimination disorders. 29.3% of persons with PWS and 48.8% of persons with FXS had at least one elimination disorder. Persons with FXS also had more often DUI (29.5% vs. 12.0%) and FI (28.9% vs. 12.6%). Rates of NE were similar in both groups (22.0% in PWS vs. 28.9% in FXS). Young adults with PWS had more behavioral symptoms in the clinical range (70.8% vs. 48.3%). Incontinence and behavioral symptoms were significantly associated in persons with FXS.

CONCLUSIONS

NE, DUI, and FI are very common in persons with FXS and PWS and are associated with other behavioral symptoms in persons with FXS. They persist into adulthood. Early assessment and treatment are recommended.

Authors+Show Affiliations

Department of Child and Adolescent Psychiatry, Saarland University Hospital, Homburg, Germany. monika.equit@uniklinikum-saarland.deNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

23239431

Citation

Equit, Monika, et al. "Elimination Disorders in Persons With Prader-Willi and Fragile-X Syndromes." Neurourology and Urodynamics, vol. 32, no. 7, 2013, pp. 986-92.
Equit M, Piro-Hussong A, Niemczyk J, et al. Elimination disorders in persons with Prader-Willi and Fragile-X syndromes. Neurourol Urodyn. 2013;32(7):986-92.
Equit, M., Piro-Hussong, A., Niemczyk, J., Curfs, L., & von Gontard, A. (2013). Elimination disorders in persons with Prader-Willi and Fragile-X syndromes. Neurourology and Urodynamics, 32(7), 986-92. https://doi.org/10.1002/nau.22352
Equit M, et al. Elimination Disorders in Persons With Prader-Willi and Fragile-X Syndromes. Neurourol Urodyn. 2013;32(7):986-92. PubMed PMID: 23239431.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Elimination disorders in persons with Prader-Willi and Fragile-X syndromes. AU - Equit,Monika, AU - Piro-Hussong,Aline, AU - Niemczyk,Justine, AU - Curfs,Leopold, AU - von Gontard,Alexander, Y1 - 2012/12/12/ PY - 2012/08/09/received PY - 2012/10/29/accepted PY - 2012/12/15/entrez PY - 2012/12/15/pubmed PY - 2014/3/19/medline KW - Prader-Willi syndrome KW - daytime urinary incontinence KW - fecal incontinence KW - fragile-X syndrome KW - intellectual disability KW - nocturnal enuresis SP - 986 EP - 92 JF - Neurourology and urodynamics JO - Neurourol Urodyn VL - 32 IS - 7 N2 - AIMS: Elimination disorders are common in typically developing children. Only few studies have addressed elimination disorders in persons with intellectual disability (ID)-and even fewer studies in those with specific syndromes. The aim of the study was to investigate the rates of elimination disorders and behavioral symptoms in persons with Prader-Willi (PWS) and Fragile-X syndromes (FXS) in a large sample. METHODS: Three hundred fifty-seven persons with PWS or FXS were recruited through parent self-help groups. A questionnaire regarding elimination symptoms, as well as the child behavior checklist (CBCL)/young adult behavior checklist (YABCL) were filled out by parents or caregivers. RESULTS: The sample included 191 persons with PWS (54.5% male) with a mean age of 20.0 years and 166 persons with FXS (92.2% male) with a mean age of 15.4 years. Persons with FXS were significantly more often affected by elimination disorders. 29.3% of persons with PWS and 48.8% of persons with FXS had at least one elimination disorder. Persons with FXS also had more often DUI (29.5% vs. 12.0%) and FI (28.9% vs. 12.6%). Rates of NE were similar in both groups (22.0% in PWS vs. 28.9% in FXS). Young adults with PWS had more behavioral symptoms in the clinical range (70.8% vs. 48.3%). Incontinence and behavioral symptoms were significantly associated in persons with FXS. CONCLUSIONS: NE, DUI, and FI are very common in persons with FXS and PWS and are associated with other behavioral symptoms in persons with FXS. They persist into adulthood. Early assessment and treatment are recommended. SN - 1520-6777 UR - https://www.unboundmedicine.com/medline/citation/23239431/Elimination_disorders_in_persons_with_Prader_Willi_and_Fragile_X_syndromes_ L2 - https://doi.org/10.1002/nau.22352 DB - PRIME DP - Unbound Medicine ER -