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A prospective study of dorsal root ganglion stimulation for the relief of chronic pain.
Neuromodulation. 2013 Jan-Feb; 16(1):67-71; discussion 71-2.N

Abstract

OBJECTIVE

The article aims to study the safety and effectiveness of dorsal root ganglion (DRG) stimulation with a new device in the treatment of chronic pain.

DESIGN

This is a prospective, single-arm, pilot study.

SETTING

Four clinical centers were used as setting for this study.

PATIENTS

Ten (10) patients with chronic intractable pain of the trunk and/or limbs were included.

INTERVENTION

A trial period of DRG stimulation was studied. Two to four leads, each with four electrical contacts, were inserted using a minimally invasive epidural approach and steered toward the lateral epidural space, near the DRG. Leads were attached to an external trial stimulator and stimulation therapy was provided for three to seven days.

OUTCOME MEASURES

Pain reduction using a visual analog scale, subject and physician-rated improvement, adverse event (AE) rates, device programming settings, and medication utilization was evaluated at baseline and at prospective follow-up time points during stimulation.

RESULTS

On average, there was a 70% reduction in pain following stimulation (p = 0.0007). Eight of the nine patients experienced a clinically meaningful (>30%) reduction in pain, and seven of the nine reduced their pain medication utilization. Pain relief in specific anatomical regions such as the leg, back, and foot was also observed. No device-related AEs were reported.

CONCLUSIONS

These initial results suggest that stimulation of the DRG can reduce pain in those patients suffering from chronic pain. DRG stimulation may offer several potential benefits over other neuromodulation techniques, including the ability to target difficult-to-reach anatomies such as the low back and foot.

Authors+Show Affiliations

Center for Pain Relief, Charleston, WV 25301, USA. doctdeer@aol.comNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Clinical Trial
Journal Article
Multicenter Study
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

23240657

Citation

Deer, Timothy R., et al. "A Prospective Study of Dorsal Root Ganglion Stimulation for the Relief of Chronic Pain." Neuromodulation : Journal of the International Neuromodulation Society, vol. 16, no. 1, 2013, pp. 67-71; discussion 71-2.
Deer TR, Grigsby E, Weiner RL, et al. A prospective study of dorsal root ganglion stimulation for the relief of chronic pain. Neuromodulation. 2013;16(1):67-71; discussion 71-2.
Deer, T. R., Grigsby, E., Weiner, R. L., Wilcosky, B., & Kramer, J. M. (2013). A prospective study of dorsal root ganglion stimulation for the relief of chronic pain. Neuromodulation : Journal of the International Neuromodulation Society, 16(1), 67-71; discussion 71-2. https://doi.org/10.1111/ner.12013
Deer TR, et al. A Prospective Study of Dorsal Root Ganglion Stimulation for the Relief of Chronic Pain. Neuromodulation. 2013 Jan-Feb;16(1):67-71; discussion 71-2. PubMed PMID: 23240657.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - A prospective study of dorsal root ganglion stimulation for the relief of chronic pain. AU - Deer,Timothy R, AU - Grigsby,Eric, AU - Weiner,Richard L, AU - Wilcosky,Bernard, AU - Kramer,Jeffery M, Y1 - 2012/12/14/ PY - 2012/03/20/received PY - 2012/09/14/revised PY - 2012/10/10/accepted PY - 2012/12/18/entrez PY - 2012/12/18/pubmed PY - 2013/7/31/medline SP - 67-71; discussion 71-2 JF - Neuromodulation : journal of the International Neuromodulation Society JO - Neuromodulation VL - 16 IS - 1 N2 - OBJECTIVE: The article aims to study the safety and effectiveness of dorsal root ganglion (DRG) stimulation with a new device in the treatment of chronic pain. DESIGN: This is a prospective, single-arm, pilot study. SETTING: Four clinical centers were used as setting for this study. PATIENTS: Ten (10) patients with chronic intractable pain of the trunk and/or limbs were included. INTERVENTION: A trial period of DRG stimulation was studied. Two to four leads, each with four electrical contacts, were inserted using a minimally invasive epidural approach and steered toward the lateral epidural space, near the DRG. Leads were attached to an external trial stimulator and stimulation therapy was provided for three to seven days. OUTCOME MEASURES: Pain reduction using a visual analog scale, subject and physician-rated improvement, adverse event (AE) rates, device programming settings, and medication utilization was evaluated at baseline and at prospective follow-up time points during stimulation. RESULTS: On average, there was a 70% reduction in pain following stimulation (p = 0.0007). Eight of the nine patients experienced a clinically meaningful (>30%) reduction in pain, and seven of the nine reduced their pain medication utilization. Pain relief in specific anatomical regions such as the leg, back, and foot was also observed. No device-related AEs were reported. CONCLUSIONS: These initial results suggest that stimulation of the DRG can reduce pain in those patients suffering from chronic pain. DRG stimulation may offer several potential benefits over other neuromodulation techniques, including the ability to target difficult-to-reach anatomies such as the low back and foot. SN - 1525-1403 UR - https://www.unboundmedicine.com/medline/citation/23240657/A_prospective_study_of_dorsal_root_ganglion_stimulation_for_the_relief_of_chronic_pain_ L2 - https://doi.org/10.1111/ner.12013 DB - PRIME DP - Unbound Medicine ER -