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Disability-adjusted life years (DALYs) for 291 diseases and injuries in 21 regions, 1990-2010: a systematic analysis for the Global Burden of Disease Study 2010.
Lancet. 2012 Dec 15; 380(9859):2197-223.Lct

Abstract

BACKGROUND

Measuring disease and injury burden in populations requires a composite metric that captures both premature mortality and the prevalence and severity of ill-health. The 1990 Global Burden of Disease study proposed disability-adjusted life years (DALYs) to measure disease burden. No comprehensive update of disease burden worldwide incorporating a systematic reassessment of disease and injury-specific epidemiology has been done since the 1990 study. We aimed to calculate disease burden worldwide and for 21 regions for 1990, 2005, and 2010 with methods to enable meaningful comparisons over time.

METHODS

We calculated DALYs as the sum of years of life lost (YLLs) and years lived with disability (YLDs). DALYs were calculated for 291 causes, 20 age groups, both sexes, and for 187 countries, and aggregated to regional and global estimates of disease burden for three points in time with strictly comparable definitions and methods. YLLs were calculated from age-sex-country-time-specific estimates of mortality by cause, with death by standardised lost life expectancy at each age. YLDs were calculated as prevalence of 1160 disabling sequelae, by age, sex, and cause, and weighted by new disability weights for each health state. Neither YLLs nor YLDs were age-weighted or discounted. Uncertainty around cause-specific DALYs was calculated incorporating uncertainty in levels of all-cause mortality, cause-specific mortality, prevalence, and disability weights.

FINDINGS

Global DALYs remained stable from 1990 (2·503 billion) to 2010 (2·490 billion). Crude DALYs per 1000 decreased by 23% (472 per 1000 to 361 per 1000). An important shift has occurred in DALY composition with the contribution of deaths and disability among children (younger than 5 years of age) declining from 41% of global DALYs in 1990 to 25% in 2010. YLLs typically account for about half of disease burden in more developed regions (high-income Asia Pacific, western Europe, high-income North America, and Australasia), rising to over 80% of DALYs in sub-Saharan Africa. In 1990, 47% of DALYs worldwide were from communicable, maternal, neonatal, and nutritional disorders, 43% from non-communicable diseases, and 10% from injuries. By 2010, this had shifted to 35%, 54%, and 11%, respectively. Ischaemic heart disease was the leading cause of DALYs worldwide in 2010 (up from fourth rank in 1990, increasing by 29%), followed by lower respiratory infections (top rank in 1990; 44% decline in DALYs), stroke (fifth in 1990; 19% increase), diarrhoeal diseases (second in 1990; 51% decrease), and HIV/AIDS (33rd in 1990; 351% increase). Major depressive disorder increased from 15th to 11th rank (37% increase) and road injury from 12th to 10th rank (34% increase). Substantial heterogeneity exists in rankings of leading causes of disease burden among regions.

INTERPRETATION

Global disease burden has continued to shift away from communicable to non-communicable diseases and from premature death to years lived with disability. In sub-Saharan Africa, however, many communicable, maternal, neonatal, and nutritional disorders remain the dominant causes of disease burden. The rising burden from mental and behavioural disorders, musculoskeletal disorders, and diabetes will impose new challenges on health systems. Regional heterogeneity highlights the importance of understanding local burden of disease and setting goals and targets for the post-2015 agenda taking such patterns into account. Because of improved definitions, methods, and data, these results for 1990 and 2010 supersede all previously published Global Burden of Disease results.

FUNDING

Bill & Melinda Gates Foundation.

Authors+Show Affiliations

Institute for Health Metrics and Evaluation, Seattle 98121, WA, USA. cjlm@uw.eduNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info 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Pub Type(s)

Journal Article
Research Support, N.I.H., Extramural
Research Support, N.I.H., Intramural
Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, Non-P.H.S.

Language

eng

PubMed ID

23245608

Citation

Murray, Christopher J L., et al. "Disability-adjusted Life Years (DALYs) for 291 Diseases and Injuries in 21 Regions, 1990-2010: a Systematic Analysis for the Global Burden of Disease Study 2010." Lancet (London, England), vol. 380, no. 9859, 2012, pp. 2197-223.
Murray CJ, Vos T, Lozano R, et al. Disability-adjusted life years (DALYs) for 291 diseases and injuries in 21 regions, 1990-2010: a systematic analysis for the Global Burden of Disease Study 2010. Lancet. 2012;380(9859):2197-223.
Murray, C. J., Vos, T., Lozano, R., Naghavi, M., Flaxman, A. D., Michaud, C., Ezzati, M., Shibuya, K., Salomon, J. A., Abdalla, S., Aboyans, V., Abraham, J., Ackerman, I., Aggarwal, R., Ahn, S. Y., Ali, M. K., Alvarado, M., Anderson, H. R., Anderson, L. M., ... Memish, Z. A. (2012). Disability-adjusted life years (DALYs) for 291 diseases and injuries in 21 regions, 1990-2010: a systematic analysis for the Global Burden of Disease Study 2010. Lancet (London, England), 380(9859), 2197-223. https://doi.org/10.1016/S0140-6736(12)61689-4
Murray CJ, et al. Disability-adjusted Life Years (DALYs) for 291 Diseases and Injuries in 21 Regions, 1990-2010: a Systematic Analysis for the Global Burden of Disease Study 2010. Lancet. 2012 Dec 15;380(9859):2197-223. PubMed PMID: 23245608.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Disability-adjusted life years (DALYs) for 291 diseases and injuries in 21 regions, 1990-2010: a systematic analysis for the Global Burden of Disease Study 2010. AU - Murray,Christopher J L, AU - Vos,Theo, AU - Lozano,Rafael, AU - Naghavi,Mohsen, AU - Flaxman,Abraham D, AU - Michaud,Catherine, AU - Ezzati,Majid, AU - Shibuya,Kenji, AU - Salomon,Joshua A, AU - Abdalla,Safa, AU - Aboyans,Victor, AU - Abraham,Jerry, AU - Ackerman,Ilana, AU - Aggarwal,Rakesh, AU - Ahn,Stephanie Y, AU - Ali,Mohammed K, AU - Alvarado,Miriam, AU - Anderson,H Ross, AU - Anderson,Laurie M, AU - Andrews,Kathryn G, AU - Atkinson,Charles, AU - Baddour,Larry M, AU - Bahalim,Adil N, AU - Barker-Collo,Suzanne, AU - Barrero,Lope H, AU - Bartels,David H, AU - Basáñez,Maria-Gloria, AU - Baxter,Amanda, AU - Bell,Michelle L, AU - Benjamin,Emelia J, AU - Bennett,Derrick, AU - Bernabé,Eduardo, AU - Bhalla,Kavi, AU - Bhandari,Bishal, AU - Bikbov,Boris, AU - Bin Abdulhak,Aref, AU - Birbeck,Gretchen, AU - Black,James A, AU - Blencowe,Hannah, AU - Blore,Jed D, AU - Blyth,Fiona, AU - Bolliger,Ian, AU - Bonaventure,Audrey, AU - Boufous,Soufiane, AU - Bourne,Rupert, AU - Boussinesq,Michel, AU - Braithwaite,Tasanee, AU - Brayne,Carol, AU - Bridgett,Lisa, AU - Brooker,Simon, AU - Brooks,Peter, AU - Brugha,Traolach S, AU - Bryan-Hancock,Claire, AU - Bucello,Chiara, AU - Buchbinder,Rachelle, AU - Buckle,Geoffrey, AU - Budke,Christine M, AU - Burch,Michael, AU - Burney,Peter, AU - Burstein,Roy, AU - Calabria,Bianca, AU - Campbell,Benjamin, AU - Canter,Charles E, AU - Carabin,Hélène, AU - Carapetis,Jonathan, AU - Carmona,Loreto, AU - Cella,Claudia, AU - Charlson,Fiona, AU - Chen,Honglei, AU - Cheng,Andrew Tai-Ann, AU - Chou,David, AU - Chugh,Sumeet S, AU - Coffeng,Luc E, AU - Colan,Steven D, AU - Colquhoun,Samantha, AU - Colson,K Ellicott, AU - Condon,John, AU - Connor,Myles D, AU - Cooper,Leslie T, AU - Corriere,Matthew, AU - Cortinovis,Monica, AU - de Vaccaro,Karen Courville, AU - Couser,William, AU - Cowie,Benjamin C, AU - Criqui,Michael H, AU - Cross,Marita, AU - Dabhadkar,Kaustubh C, AU - Dahiya,Manu, AU - Dahodwala,Nabila, AU - Damsere-Derry,James, AU - Danaei,Goodarz, AU - Davis,Adrian, AU - De Leo,Diego, AU - Degenhardt,Louisa, AU - Dellavalle,Robert, AU - Delossantos,Allyne, AU - Denenberg,Julie, AU - Derrett,Sarah, AU - Des Jarlais,Don C, AU - Dharmaratne,Samath D, AU - Dherani,Mukesh, AU - Diaz-Torne,Cesar, AU - Dolk,Helen, AU - Dorsey,E Ray, AU - Driscoll,Tim, AU - Duber,Herbert, AU - Ebel,Beth, AU - Edmond,Karen, AU - Elbaz,Alexis, AU - Ali,Suad Eltahir, AU - Erskine,Holly, AU - Erwin,Patricia J, AU - Espindola,Patricia, AU - Ewoigbokhan,Stalin E, AU - Farzadfar,Farshad, AU - Feigin,Valery, AU - Felson,David T, AU - Ferrari,Alize, AU - Ferri,Cleusa P, AU - Fèvre,Eric M, AU - Finucane,Mariel M, AU - Flaxman,Seth, AU - Flood,Louise, AU - Foreman,Kyle, AU - Forouzanfar,Mohammad H, AU - Fowkes,Francis Gerry R, AU - Fransen,Marlene, AU - Freeman,Michael K, AU - Gabbe,Belinda J, AU - Gabriel,Sherine E, AU - Gakidou,Emmanuela, AU - Ganatra,Hammad A, AU - Garcia,Bianca, AU - Gaspari,Flavio, AU - Gillum,Richard F, AU - Gmel,Gerhard, AU - Gonzalez-Medina,Diego, AU - Gosselin,Richard, AU - Grainger,Rebecca, AU - Grant,Bridget, AU - Groeger,Justina, AU - Guillemin,Francis, AU - Gunnell,David, AU - Gupta,Ramyani, AU - Haagsma,Juanita, AU - Hagan,Holly, AU - Halasa,Yara A, AU - Hall,Wayne, AU - Haring,Diana, AU - Haro,Josep Maria, AU - Harrison,James E, AU - Havmoeller,Rasmus, AU - Hay,Roderick J, AU - Higashi,Hideki, AU - Hill,Catherine, AU - Hoen,Bruno, AU - Hoffman,Howard, AU - Hotez,Peter J, AU - Hoy,Damian, AU - Huang,John J, AU - Ibeanusi,Sydney E, AU - Jacobsen,Kathryn H, AU - James,Spencer L, AU - Jarvis,Deborah, AU - Jasrasaria,Rashmi, AU - Jayaraman,Sudha, AU - Johns,Nicole, AU - Jonas,Jost B, AU - Karthikeyan,Ganesan, AU - Kassebaum,Nicholas, AU - Kawakami,Norito, AU - Keren,Andre, AU - Khoo,Jon-Paul, AU - King,Charles H, AU - Knowlton,Lisa Marie, AU - Kobusingye,Olive, AU - Koranteng,Adofo, AU - Krishnamurthi,Rita, AU - Laden,Francine, AU - Lalloo,Ratilal, AU - Laslett,Laura L, AU - Lathlean,Tim, AU - Leasher,Janet L, AU - Lee,Yong Yi, AU - Leigh,James, AU - Levinson,Daphna, AU - Lim,Stephen S, AU - Limb,Elizabeth, AU - Lin,John Kent, AU - Lipnick,Michael, AU - Lipshultz,Steven E, AU - Liu,Wei, AU - Loane,Maria, AU - Ohno,Summer Lockett, AU - Lyons,Ronan, AU - Mabweijano,Jacqueline, AU - MacIntyre,Michael F, AU - Malekzadeh,Reza, AU - Mallinger,Leslie, AU - Manivannan,Sivabalan, AU - Marcenes,Wagner, AU - March,Lyn, AU - Margolis,David J, AU - Marks,Guy B, AU - Marks,Robin, AU - Matsumori,Akira, AU - Matzopoulos,Richard, AU - Mayosi,Bongani M, AU - McAnulty,John H, AU - McDermott,Mary M, AU - McGill,Neil, AU - McGrath,John, AU - Medina-Mora,Maria Elena, AU - Meltzer,Michele, AU - Mensah,George A, AU - Merriman,Tony R, AU - Meyer,Ana-Claire, AU - Miglioli,Valeria, AU - Miller,Matthew, AU - Miller,Ted R, AU - Mitchell,Philip B, AU - Mock,Charles, AU - Mocumbi,Ana Olga, AU - Moffitt,Terrie E, AU - Mokdad,Ali A, AU - Monasta,Lorenzo, AU - Montico,Marcella, AU - Moradi-Lakeh,Maziar, AU - Moran,Andrew, AU - Morawska,Lidia, AU - Mori,Rintaro, AU - Murdoch,Michele E, AU - Mwaniki,Michael K, AU - Naidoo,Kovin, AU - Nair,M Nathan, AU - Naldi,Luigi, AU - Narayan,K M Venkat, AU - Nelson,Paul K, AU - Nelson,Robert G, AU - Nevitt,Michael C, AU - Newton,Charles R, AU - Nolte,Sandra, AU - Norman,Paul, AU - Norman,Rosana, AU - O'Donnell,Martin, AU - O'Hanlon,Simon, AU - Olives,Casey, AU - Omer,Saad B, AU - Ortblad,Katrina, AU - Osborne,Richard, AU - Ozgediz,Doruk, AU - Page,Andrew, AU - Pahari,Bishnu, AU - Pandian,Jeyaraj Durai, AU - Rivero,Andrea Panozo, AU - Patten,Scott B, AU - Pearce,Neil, AU - Padilla,Rogelio Perez, AU - Perez-Ruiz,Fernando, AU - Perico,Norberto, AU - Pesudovs,Konrad, AU - Phillips,David, AU - Phillips,Michael R, AU - Pierce,Kelsey, AU - Pion,Sébastien, AU - Polanczyk,Guilherme V, AU - Polinder,Suzanne, AU - Pope,C Arden,3rd AU - Popova,Svetlana, AU - Porrini,Esteban, AU - Pourmalek,Farshad, AU - Prince,Martin, AU - Pullan,Rachel L, AU - Ramaiah,Kapa D, AU - Ranganathan,Dharani, AU - Razavi,Homie, AU - Regan,Mathilda, AU - Rehm,Jürgen T, AU - 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Thurston,George D, AU - Tleyjeh,Imad M, AU - Tonelli,Marcello, AU - Towbin,Jeffrey A, AU - Truelsen,Thomas, AU - Tsilimbaris,Miltiadis K, AU - Ubeda,Clotilde, AU - Undurraga,Eduardo A, AU - van der Werf,Marieke J, AU - van Os,Jim, AU - Vavilala,Monica S, AU - Venketasubramanian,N, AU - Wang,Mengru, AU - Wang,Wenzhi, AU - Watt,Kerrianne, AU - Weatherall,David J, AU - Weinstock,Martin A, AU - Weintraub,Robert, AU - Weisskopf,Marc G, AU - Weissman,Myrna M, AU - White,Richard A, AU - Whiteford,Harvey, AU - Wiebe,Natasha, AU - Wiersma,Steven T, AU - Wilkinson,James D, AU - Williams,Hywel C, AU - Williams,Sean R M, AU - Witt,Emma, AU - Wolfe,Frederick, AU - Woolf,Anthony D, AU - Wulf,Sarah, AU - Yeh,Pon-Hsiu, AU - Zaidi,Anita K M, AU - Zheng,Zhi-Jie, AU - Zonies,David, AU - Lopez,Alan D, AU - AlMazroa,Mohammad A, AU - Memish,Ziad A, PY - 2012/12/19/entrez PY - 2012/12/19/pubmed PY - 2013/1/24/medline SP - 2197 EP - 223 JF - Lancet (London, England) JO - Lancet VL - 380 IS - 9859 N2 - BACKGROUND: Measuring disease and injury burden in populations requires a composite metric that captures both premature mortality and the prevalence and severity of ill-health. The 1990 Global Burden of Disease study proposed disability-adjusted life years (DALYs) to measure disease burden. No comprehensive update of disease burden worldwide incorporating a systematic reassessment of disease and injury-specific epidemiology has been done since the 1990 study. We aimed to calculate disease burden worldwide and for 21 regions for 1990, 2005, and 2010 with methods to enable meaningful comparisons over time. METHODS: We calculated DALYs as the sum of years of life lost (YLLs) and years lived with disability (YLDs). DALYs were calculated for 291 causes, 20 age groups, both sexes, and for 187 countries, and aggregated to regional and global estimates of disease burden for three points in time with strictly comparable definitions and methods. YLLs were calculated from age-sex-country-time-specific estimates of mortality by cause, with death by standardised lost life expectancy at each age. YLDs were calculated as prevalence of 1160 disabling sequelae, by age, sex, and cause, and weighted by new disability weights for each health state. Neither YLLs nor YLDs were age-weighted or discounted. Uncertainty around cause-specific DALYs was calculated incorporating uncertainty in levels of all-cause mortality, cause-specific mortality, prevalence, and disability weights. FINDINGS: Global DALYs remained stable from 1990 (2·503 billion) to 2010 (2·490 billion). Crude DALYs per 1000 decreased by 23% (472 per 1000 to 361 per 1000). An important shift has occurred in DALY composition with the contribution of deaths and disability among children (younger than 5 years of age) declining from 41% of global DALYs in 1990 to 25% in 2010. YLLs typically account for about half of disease burden in more developed regions (high-income Asia Pacific, western Europe, high-income North America, and Australasia), rising to over 80% of DALYs in sub-Saharan Africa. In 1990, 47% of DALYs worldwide were from communicable, maternal, neonatal, and nutritional disorders, 43% from non-communicable diseases, and 10% from injuries. By 2010, this had shifted to 35%, 54%, and 11%, respectively. Ischaemic heart disease was the leading cause of DALYs worldwide in 2010 (up from fourth rank in 1990, increasing by 29%), followed by lower respiratory infections (top rank in 1990; 44% decline in DALYs), stroke (fifth in 1990; 19% increase), diarrhoeal diseases (second in 1990; 51% decrease), and HIV/AIDS (33rd in 1990; 351% increase). Major depressive disorder increased from 15th to 11th rank (37% increase) and road injury from 12th to 10th rank (34% increase). Substantial heterogeneity exists in rankings of leading causes of disease burden among regions. INTERPRETATION: Global disease burden has continued to shift away from communicable to non-communicable diseases and from premature death to years lived with disability. In sub-Saharan Africa, however, many communicable, maternal, neonatal, and nutritional disorders remain the dominant causes of disease burden. The rising burden from mental and behavioural disorders, musculoskeletal disorders, and diabetes will impose new challenges on health systems. Regional heterogeneity highlights the importance of understanding local burden of disease and setting goals and targets for the post-2015 agenda taking such patterns into account. Because of improved definitions, methods, and data, these results for 1990 and 2010 supersede all previously published Global Burden of Disease results. FUNDING: Bill & Melinda Gates Foundation. SN - 1474-547X UR - https://www.unboundmedicine.com/medline/citation/23245608/Disability_adjusted_life_years__DALYs__for_291_diseases_and_injuries_in_21_regions_1990_2010:_a_systematic_analysis_for_the_Global_Burden_of_Disease_Study_2010_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0140-6736(12)61689-4 DB - PRIME DP - Unbound Medicine ER -