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Influence of a latrophilin 3 (LPHN3) risk haplotype on event-related potential measures of cognitive response control in attention-deficit hyperactivity disorder (ADHD).
Eur Neuropsychopharmacol 2013; 23(6):458-68EN

Abstract

Current research strategies have made great efforts to further elucidate the complex genetic architecture of attention-deficit hyperactivity disorder (ADHD). The present study examined the impact of an LPHN3 haplotype that has recently been associated with ADHD (Arcos-Burgos et al., 2010) on neural activity in a visual Go-NoGo task. Two hundred sixteen adult ADHD patients completed a Continuous Performance Test (CPT) while the ongoing EEG was simultaneously recorded. Results showed that patients carrying two copies of the LPHN3 risk haplotype (n=114) made more omission errors and had a more anterior Go-centroid of the P300 than patients carrying at least one LPHN3 non-risk haplotype (n=102). Accordingly, the NoGo-Anteriorization (NGA; topographical ERP difference of the Go- and NoGo-condition), a neurophysiological marker of prefrontal functioning, was reduced in the LPHN3 high risk group. However, in the NoGo-condition itself no marked differences attributable to the LPHN3 haplotype could be found. Our findings indicate that, within a sample of ADHD patients, the LPHN3 gene impacts behavioral and neurophysiological measures of cognitive response control. The results of our study further strengthen the concept of an LPHN3 risk haplotype for ADHD and support the usefulness of the endophenotype approach in psychiatric and psychological research.

Authors+Show Affiliations

Department of Psychiatry and Psychotherapy, University of Tuebingen, Germany. Andreas.Fallgatter@med.uni-tuebingen.deNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

23245769

Citation

Fallgatter, Andreas J., et al. "Influence of a Latrophilin 3 (LPHN3) Risk Haplotype On Event-related Potential Measures of Cognitive Response Control in Attention-deficit Hyperactivity Disorder (ADHD)." European Neuropsychopharmacology : the Journal of the European College of Neuropsychopharmacology, vol. 23, no. 6, 2013, pp. 458-68.
Fallgatter AJ, Ehlis AC, Dresler T, et al. Influence of a latrophilin 3 (LPHN3) risk haplotype on event-related potential measures of cognitive response control in attention-deficit hyperactivity disorder (ADHD). Eur Neuropsychopharmacol. 2013;23(6):458-68.
Fallgatter, A. J., Ehlis, A. C., Dresler, T., Reif, A., Jacob, C. P., Arcos-Burgos, M., ... Lesch, K. P. (2013). Influence of a latrophilin 3 (LPHN3) risk haplotype on event-related potential measures of cognitive response control in attention-deficit hyperactivity disorder (ADHD). European Neuropsychopharmacology : the Journal of the European College of Neuropsychopharmacology, 23(6), pp. 458-68. doi:10.1016/j.euroneuro.2012.11.001.
Fallgatter AJ, et al. Influence of a Latrophilin 3 (LPHN3) Risk Haplotype On Event-related Potential Measures of Cognitive Response Control in Attention-deficit Hyperactivity Disorder (ADHD). Eur Neuropsychopharmacol. 2013;23(6):458-68. PubMed PMID: 23245769.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Influence of a latrophilin 3 (LPHN3) risk haplotype on event-related potential measures of cognitive response control in attention-deficit hyperactivity disorder (ADHD). AU - Fallgatter,Andreas J, AU - Ehlis,Ann-Christine, AU - Dresler,Thomas, AU - Reif,Andreas, AU - Jacob,Christian P, AU - Arcos-Burgos,Mauricio, AU - Muenke,Maximilian, AU - Lesch,Klaus-Peter, Y1 - 2012/12/12/ PY - 2012/04/12/received PY - 2012/10/16/revised PY - 2012/11/03/accepted PY - 2012/12/19/entrez PY - 2012/12/19/pubmed PY - 2013/12/24/medline SP - 458 EP - 68 JF - European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology JO - Eur Neuropsychopharmacol VL - 23 IS - 6 N2 - Current research strategies have made great efforts to further elucidate the complex genetic architecture of attention-deficit hyperactivity disorder (ADHD). The present study examined the impact of an LPHN3 haplotype that has recently been associated with ADHD (Arcos-Burgos et al., 2010) on neural activity in a visual Go-NoGo task. Two hundred sixteen adult ADHD patients completed a Continuous Performance Test (CPT) while the ongoing EEG was simultaneously recorded. Results showed that patients carrying two copies of the LPHN3 risk haplotype (n=114) made more omission errors and had a more anterior Go-centroid of the P300 than patients carrying at least one LPHN3 non-risk haplotype (n=102). Accordingly, the NoGo-Anteriorization (NGA; topographical ERP difference of the Go- and NoGo-condition), a neurophysiological marker of prefrontal functioning, was reduced in the LPHN3 high risk group. However, in the NoGo-condition itself no marked differences attributable to the LPHN3 haplotype could be found. Our findings indicate that, within a sample of ADHD patients, the LPHN3 gene impacts behavioral and neurophysiological measures of cognitive response control. The results of our study further strengthen the concept of an LPHN3 risk haplotype for ADHD and support the usefulness of the endophenotype approach in psychiatric and psychological research. SN - 1873-7862 UR - https://www.unboundmedicine.com/medline/citation/23245769/Influence_of_a_latrophilin_3__LPHN3__risk_haplotype_on_event_related_potential_measures_of_cognitive_response_control_in_attention_deficit_hyperactivity_disorder__ADHD__ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0924-977X(12)00310-0 DB - PRIME DP - Unbound Medicine ER -