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Improved renal function 12 months after bariatric surgery.
Surg Obes Relat Dis. 2013 Mar-Apr; 9(2):202-6.SO

Abstract

BACKGROUND

Obesity is a risk factor for developing chronic kidney disease (CKD) that may be improved with bariatric surgical weight reduction. The objective of this study was to investigate changes in the glomerular filtration rate (GFR) in severely obese patients 1 year after bariatric surgery.

METHODS

GFR was measured in 233 severely obese patients before and more than 12 months after bariatric surgery. Patients were separated by baseline GFR: hyperfiltration (GFR>125 mL/min), normal (GFR 125-90 mL/min), CKD stage 2 (GFR 89-60 mL/min), and CKD stage 3 (59-30 mL/min). The groups were reanalyzed 12 months after bariatric surgery.

RESULTS

Of the 233 patients, 61 (26.2%) had hyperfiltration, 127 (54.5%) were normal, 39 (16.7%) had CKD stage 2, and 6 (2.6%) had CKD stage 3. The mean GFR was 146.4±17.1 mL/min in the hyperfiltration group, 105.7±9.6 mL/min in the normal group, 76.8±16.7 mL/min in the CKD stage 2 group, and 49.5±6.6 mL/min in the CKD stage 3 group. The mean GFR 1 year after weight loss surgery decreased to 133.9±25.7 mL/min in the hyperfiltration group, increased to 114.2±22.2 mL/min in the normal group, increased to 93.3±20.4 mL/min in the CKD stage 2 group, and increased to 66.8±19.3 mL/min in the CKD stage 3 group.

CONCLUSIONS

Abnormal renal function was common in severely obese patients. Bariatric surgery-induced weight loss had positive effects on renal function at 1 year after surgery.

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Publisher Full Text (DOI)

Authors+Show Affiliations

Hou CC
Department of Internal Medicine, Min-Sheng General Hospital, Taoyuan, Taiwan, Republic of China.
Shyu RS
No affiliation info available
Lee WJ
No affiliation info available
Ser KH
No affiliation info available
Lee YC
No affiliation info available
Chen SC
No affiliation info available

MeSH

AdultBariatric SurgeryBody Mass IndexFemaleFollow-Up StudiesGlomerular Filtration RateHumansLaparoscopyMaleMiddle AgedObesityRenal Insufficiency, ChronicRetrospective StudiesTreatment OutcomeWeight LossYoung Adult

Pub Type(s)

Journal Article

Language

eng

PubMed ID

23246320

Citation

Hou, Chun-Cheng, et al. "Improved Renal Function 12 Months After Bariatric Surgery." Surgery for Obesity and Related Diseases : Official Journal of the American Society for Bariatric Surgery, vol. 9, no. 2, 2013, pp. 202-6.
Hou CC, Shyu RS, Lee WJ, et al. Improved renal function 12 months after bariatric surgery. Surg Obes Relat Dis. 2013;9(2):202-6.
Hou, C. C., Shyu, R. S., Lee, W. J., Ser, K. H., Lee, Y. C., & Chen, S. C. (2013). Improved renal function 12 months after bariatric surgery. Surgery for Obesity and Related Diseases : Official Journal of the American Society for Bariatric Surgery, 9(2), 202-6. https://doi.org/10.1016/j.soard.2012.10.005
Hou CC, et al. Improved Renal Function 12 Months After Bariatric Surgery. Surg Obes Relat Dis. 2013 Mar-Apr;9(2):202-6. PubMed PMID: 23246320.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Improved renal function 12 months after bariatric surgery. AU - Hou,Chun-Cheng, AU - Shyu,Ren-Shi, AU - Lee,Wei-Jei, AU - Ser,Kong-Han, AU - Lee,Yi-Chih, AU - Chen,Shu-Chu, Y1 - 2012/10/26/ PY - 2012/04/18/received PY - 2012/10/10/revised PY - 2012/10/11/accepted PY - 2012/12/19/entrez PY - 2012/12/19/pubmed PY - 2013/9/14/medline SP - 202 EP - 6 JF - Surgery for obesity and related diseases : official journal of the American Society for Bariatric Surgery JO - Surg Obes Relat Dis VL - 9 IS - 2 N2 - BACKGROUND: Obesity is a risk factor for developing chronic kidney disease (CKD) that may be improved with bariatric surgical weight reduction. The objective of this study was to investigate changes in the glomerular filtration rate (GFR) in severely obese patients 1 year after bariatric surgery. METHODS: GFR was measured in 233 severely obese patients before and more than 12 months after bariatric surgery. Patients were separated by baseline GFR: hyperfiltration (GFR>125 mL/min), normal (GFR 125-90 mL/min), CKD stage 2 (GFR 89-60 mL/min), and CKD stage 3 (59-30 mL/min). The groups were reanalyzed 12 months after bariatric surgery. RESULTS: Of the 233 patients, 61 (26.2%) had hyperfiltration, 127 (54.5%) were normal, 39 (16.7%) had CKD stage 2, and 6 (2.6%) had CKD stage 3. The mean GFR was 146.4±17.1 mL/min in the hyperfiltration group, 105.7±9.6 mL/min in the normal group, 76.8±16.7 mL/min in the CKD stage 2 group, and 49.5±6.6 mL/min in the CKD stage 3 group. The mean GFR 1 year after weight loss surgery decreased to 133.9±25.7 mL/min in the hyperfiltration group, increased to 114.2±22.2 mL/min in the normal group, increased to 93.3±20.4 mL/min in the CKD stage 2 group, and increased to 66.8±19.3 mL/min in the CKD stage 3 group. CONCLUSIONS: Abnormal renal function was common in severely obese patients. Bariatric surgery-induced weight loss had positive effects on renal function at 1 year after surgery. SN - 1878-7533 UR - https://www.unboundmedicine.com/medline/citation/23246320/Improved_renal_function_12_months_after_bariatric_surgery_ DB - PRIME DP - Unbound Medicine ER -