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Phytoestrogens for menopausal bone loss and climacteric symptoms.
J Steroid Biochem Mol Biol. 2014 Jan; 139:294-301.JS

Abstract

Women have always looked for non-hormonal options to alleviate menopausal vasomotor symptoms and prevent menopausal bone loss. The use of complementary and alternative medicine for these purposes has particularly increased after the publication of the Women's Health Initiative's results suggesting that there might be more risks than benefits with hormone replacement. Phytoestrogens are plant-derived estrogens that, although less potent than estradiol, bind to the estrogen receptor and can function as estrogen agonists or antagonists. Soy isoflavones extracted from soy are the phytoestrogens most commonly used by menopausal women. Because typical Western diets are low in phytoestrogens and taking into account the general difficulty in changing dietary habits, most clinical trials in Western women have used isoflavone-fortified foods or isoflavone tablets. Although some women might experience a reduction in the frequency or severity of hot flashes, most studies point towards the lack of effectiveness of isoflavones derived from soy or red clover, even in large doses, in the prevention of hot flashes and menopausal bone loss. This article is part of a Special Issue entitled 'Phytoestrogens'.

Authors+Show Affiliations

Endocrinology Section, Bruce W. Carter Veterans Affairs Medical Center, Miami, FL 33125, USA; Department of Medicine, University of Miami Miller School of Medicine, Miami, FL 33101, USA.No affiliation info available

Pub Type(s)

Journal Article
Review

Language

eng

PubMed ID

23246986

Citation

Lagari, Violet S., and Silvina Levis. "Phytoestrogens for Menopausal Bone Loss and Climacteric Symptoms." The Journal of Steroid Biochemistry and Molecular Biology, vol. 139, 2014, pp. 294-301.
Lagari VS, Levis S. Phytoestrogens for menopausal bone loss and climacteric symptoms. J Steroid Biochem Mol Biol. 2014;139:294-301.
Lagari, V. S., & Levis, S. (2014). Phytoestrogens for menopausal bone loss and climacteric symptoms. The Journal of Steroid Biochemistry and Molecular Biology, 139, 294-301. https://doi.org/10.1016/j.jsbmb.2012.12.002
Lagari VS, Levis S. Phytoestrogens for Menopausal Bone Loss and Climacteric Symptoms. J Steroid Biochem Mol Biol. 2014;139:294-301. PubMed PMID: 23246986.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Phytoestrogens for menopausal bone loss and climacteric symptoms. AU - Lagari,Violet S, AU - Levis,Silvina, Y1 - 2012/12/14/ PY - 2012/08/29/received PY - 2012/11/27/revised PY - 2012/12/02/accepted PY - 2012/12/19/entrez PY - 2012/12/19/pubmed PY - 2014/2/4/medline KW - Bone health KW - Climacteric symptoms KW - Fractures KW - Menopause KW - Osteoporosis KW - Phytoestrogens SP - 294 EP - 301 JF - The Journal of steroid biochemistry and molecular biology JO - J. Steroid Biochem. Mol. Biol. VL - 139 N2 - Women have always looked for non-hormonal options to alleviate menopausal vasomotor symptoms and prevent menopausal bone loss. The use of complementary and alternative medicine for these purposes has particularly increased after the publication of the Women's Health Initiative's results suggesting that there might be more risks than benefits with hormone replacement. Phytoestrogens are plant-derived estrogens that, although less potent than estradiol, bind to the estrogen receptor and can function as estrogen agonists or antagonists. Soy isoflavones extracted from soy are the phytoestrogens most commonly used by menopausal women. Because typical Western diets are low in phytoestrogens and taking into account the general difficulty in changing dietary habits, most clinical trials in Western women have used isoflavone-fortified foods or isoflavone tablets. Although some women might experience a reduction in the frequency or severity of hot flashes, most studies point towards the lack of effectiveness of isoflavones derived from soy or red clover, even in large doses, in the prevention of hot flashes and menopausal bone loss. This article is part of a Special Issue entitled 'Phytoestrogens'. SN - 1879-1220 UR - https://www.unboundmedicine.com/medline/citation/23246986/Phytoestrogens_for_menopausal_bone_loss_and_climacteric_symptoms_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0960-0760(12)00254-3 DB - PRIME DP - Unbound Medicine ER -