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Newly developed surface modification punches treated with alloying techniques reduce sticking during the manufacture of ibuprofen tablets.
Int J Pharm. 2013 Jan 30; 441(1-2):128-34.IJ

Abstract

Sticking is a serious problem during the manufacturing process of tablets. In order to prevent this, we used alloying techniques to prepare metal hardening (MH) and electron beam processing infinite product (EIP) punches with rougher asperity of surfaces than a hard chrome plated (HCr) punch. This study evaluated the anti-sticking properties of the MH and EIP punches compared to the HCr punch, using quantitative scraper force measurements and visual observation, for the manufacture of ibuprofen (Ibu) tablets. The anti-sticking property mechanism of the MH and EIP punches was also confirmed. The amount of Ibu adhering to the punch surface was 66% lower for the MH and EIP punches than for the HCr punch, suggesting a superior anti-sticking property of the MH and EIP punches. The scraper force of the HCr punch was 2.60-4.28 N, while that for the MH and EIP punches was 0.54-1.64 N and 0.42-1.33 N, respectively. The result of X-ray photoelectron spectroscopy suggested that the anti-sticking property of the EIP punch was attributed by the rough asperity as well as existence of low friction substance carbon fluoride on the punch surface. In conclusion, this study provides new evidence for the mechanisms behind the superior anti-sticking property of the MH and EIP punches.

Authors+Show Affiliations

Department of Pharmaceutical Engineering, School of Pharmaceutical Sciences, University of Shizuoka, 52-1 Yada, Shizuoka 422-8526, Japan.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

23247020

Citation

Uchimoto, Takeaki, et al. "Newly Developed Surface Modification Punches Treated With Alloying Techniques Reduce Sticking During the Manufacture of Ibuprofen Tablets." International Journal of Pharmaceutics, vol. 441, no. 1-2, 2013, pp. 128-34.
Uchimoto T, Iwao Y, Yamamoto T, et al. Newly developed surface modification punches treated with alloying techniques reduce sticking during the manufacture of ibuprofen tablets. Int J Pharm. 2013;441(1-2):128-34.
Uchimoto, T., Iwao, Y., Yamamoto, T., Sawaguchi, K., Moriuchi, T., Noguchi, S., & Itai, S. (2013). Newly developed surface modification punches treated with alloying techniques reduce sticking during the manufacture of ibuprofen tablets. International Journal of Pharmaceutics, 441(1-2), 128-34. https://doi.org/10.1016/j.ijpharm.2012.12.006
Uchimoto T, et al. Newly Developed Surface Modification Punches Treated With Alloying Techniques Reduce Sticking During the Manufacture of Ibuprofen Tablets. Int J Pharm. 2013 Jan 30;441(1-2):128-34. PubMed PMID: 23247020.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Newly developed surface modification punches treated with alloying techniques reduce sticking during the manufacture of ibuprofen tablets. AU - Uchimoto,Takeaki, AU - Iwao,Yasunori, AU - Yamamoto,Tatsuya, AU - Sawaguchi,Kazuo, AU - Moriuchi,Toshiaki, AU - Noguchi,Shuji, AU - Itai,Shigeru, Y1 - 2012/12/12/ PY - 2012/08/16/received PY - 2012/11/07/revised PY - 2012/12/05/accepted PY - 2012/12/19/entrez PY - 2012/12/19/pubmed PY - 2013/8/3/medline SP - 128 EP - 34 JF - International journal of pharmaceutics JO - Int J Pharm VL - 441 IS - 1-2 N2 - Sticking is a serious problem during the manufacturing process of tablets. In order to prevent this, we used alloying techniques to prepare metal hardening (MH) and electron beam processing infinite product (EIP) punches with rougher asperity of surfaces than a hard chrome plated (HCr) punch. This study evaluated the anti-sticking properties of the MH and EIP punches compared to the HCr punch, using quantitative scraper force measurements and visual observation, for the manufacture of ibuprofen (Ibu) tablets. The anti-sticking property mechanism of the MH and EIP punches was also confirmed. The amount of Ibu adhering to the punch surface was 66% lower for the MH and EIP punches than for the HCr punch, suggesting a superior anti-sticking property of the MH and EIP punches. The scraper force of the HCr punch was 2.60-4.28 N, while that for the MH and EIP punches was 0.54-1.64 N and 0.42-1.33 N, respectively. The result of X-ray photoelectron spectroscopy suggested that the anti-sticking property of the EIP punch was attributed by the rough asperity as well as existence of low friction substance carbon fluoride on the punch surface. In conclusion, this study provides new evidence for the mechanisms behind the superior anti-sticking property of the MH and EIP punches. SN - 1873-3476 UR - https://www.unboundmedicine.com/medline/citation/23247020/Newly_developed_surface_modification_punches_treated_with_alloying_techniques_reduce_sticking_during_the_manufacture_of_ibuprofen_tablets_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0378-5173(12)01058-7 DB - PRIME DP - Unbound Medicine ER -