Tags

Type your tag names separated by a space and hit enter

Parental alcohol consumption and risk of childhood acute lymphoblastic leukemia and brain tumors.
Cancer Causes Control. 2013 Feb; 24(2):391-402.CC

Abstract

PURPOSE

Childhood acute lymphoblastic leukemia (ALL) is the most common childhood malignancy and brain tumors (CBTs) are the leading cause of cancer death in children. In our Australian case-control studies of these cancers, we investigated whether parental alcohol consumption before or during pregnancy was associated with risk.

METHODS

Cases were identified through the ten Australian pediatric oncology centers, and controls were recruited through national random-digit dialling. Detailed information on alcohol consumption, including beverage type, amount, and timing, was collected from 690 case families (388 ALL and 302 CBT) and 1,396 control families. Data were analyzed using unconditional logistic regression.

RESULTS

We found no evidence that maternal alcohol use before or during pregnancy was associated with an increased risk of either cancer; rather, there was evidence of inverse associations, particularly with wine. For both cancers, we observed U-shaped associations with paternal alcohol consumption in the year before the pregnancy, possibly driven by reduced risk at moderate levels of beer and wine intake and increased risk associated with high levels of beer intake. Moderate intake of spirits by fathers was associated with an increased risk of CBT but not ALL. These findings would be strengthened by corroboration in other studies. While the inverse associations with wine may be interesting mechanistically, the public health message remains that maternal alcohol use during pregnancy causes serious disorders in the offspring and should be avoided.

CONCLUSIONS

Our findings suggest that men, as well as women, should limit their alcohol intake when planning a pregnancy.

Authors+Show Affiliations

Telethon Institute for Child Health Research, Centre for Child Health Research, University of Western Australia, West Perth, WA, 6872, Australia. lizm@ichr.uwa.edu.auNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

23247637

Citation

Milne, Elizabeth, et al. "Parental Alcohol Consumption and Risk of Childhood Acute Lymphoblastic Leukemia and Brain Tumors." Cancer Causes & Control : CCC, vol. 24, no. 2, 2013, pp. 391-402.
Milne E, Greenop KR, Scott RJ, et al. Parental alcohol consumption and risk of childhood acute lymphoblastic leukemia and brain tumors. Cancer Causes Control. 2013;24(2):391-402.
Milne, E., Greenop, K. R., Scott, R. J., de Klerk, N. H., Bower, C., Ashton, L. J., Heath, J. A., & Armstrong, B. K. (2013). Parental alcohol consumption and risk of childhood acute lymphoblastic leukemia and brain tumors. Cancer Causes & Control : CCC, 24(2), 391-402. https://doi.org/10.1007/s10552-012-0125-5
Milne E, et al. Parental Alcohol Consumption and Risk of Childhood Acute Lymphoblastic Leukemia and Brain Tumors. Cancer Causes Control. 2013;24(2):391-402. PubMed PMID: 23247637.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Parental alcohol consumption and risk of childhood acute lymphoblastic leukemia and brain tumors. AU - Milne,Elizabeth, AU - Greenop,Kathryn R, AU - Scott,Rodney J, AU - de Klerk,Nicholas H, AU - Bower,Carol, AU - Ashton,Lesley J, AU - Heath,John A, AU - Armstrong,Bruce K, Y1 - 2012/12/18/ PY - 2012/09/16/received PY - 2012/12/07/accepted PY - 2012/12/19/entrez PY - 2012/12/19/pubmed PY - 2013/10/31/medline SP - 391 EP - 402 JF - Cancer causes & control : CCC JO - Cancer Causes Control VL - 24 IS - 2 N2 - PURPOSE: Childhood acute lymphoblastic leukemia (ALL) is the most common childhood malignancy and brain tumors (CBTs) are the leading cause of cancer death in children. In our Australian case-control studies of these cancers, we investigated whether parental alcohol consumption before or during pregnancy was associated with risk. METHODS: Cases were identified through the ten Australian pediatric oncology centers, and controls were recruited through national random-digit dialling. Detailed information on alcohol consumption, including beverage type, amount, and timing, was collected from 690 case families (388 ALL and 302 CBT) and 1,396 control families. Data were analyzed using unconditional logistic regression. RESULTS: We found no evidence that maternal alcohol use before or during pregnancy was associated with an increased risk of either cancer; rather, there was evidence of inverse associations, particularly with wine. For both cancers, we observed U-shaped associations with paternal alcohol consumption in the year before the pregnancy, possibly driven by reduced risk at moderate levels of beer and wine intake and increased risk associated with high levels of beer intake. Moderate intake of spirits by fathers was associated with an increased risk of CBT but not ALL. These findings would be strengthened by corroboration in other studies. While the inverse associations with wine may be interesting mechanistically, the public health message remains that maternal alcohol use during pregnancy causes serious disorders in the offspring and should be avoided. CONCLUSIONS: Our findings suggest that men, as well as women, should limit their alcohol intake when planning a pregnancy. SN - 1573-7225 UR - https://www.unboundmedicine.com/medline/citation/23247637/Parental_alcohol_consumption_and_risk_of_childhood_acute_lymphoblastic_leukemia_and_brain_tumors_ L2 - https://doi.org/10.1007/s10552-012-0125-5 DB - PRIME DP - Unbound Medicine ER -