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Meta-analysis of LCPUFA supplementation of infant formula and visual acuity.
Pediatrics 2013; 131(1):e262-72Ped

Abstract

BACKGROUND AND OBJECTIVE

Long-chain polyunsaturated fatty acids (LCPUFAs) are hypothesized to affect visual acuity development in infants. Randomized controlled trials (RCTs) have been conducted to assess whether supplementation of LCPUFAs of infant formulas affects infant visual acuity. This meta-analysis was conducted to evaluate whether LCPUFA supplementation of infant formulas improves infants' visual acuity.

METHODS

PubMed and PsycInfo were searched for RCTs assessing the efficacy of LCPUFA supplementation of infant formulas on infant visual acuity. RCTs assessing the effects of LCPUFA supplementation on visual acuity (by using either visual evoked potential or behavioral methods) in the first year of life were included in this meta-analysis. Our primary outcome was the mean difference in visual resolution acuity (measured in logarithm of minimum angle of resolution [logMAR]) between supplemented and unsupplemented infants. We also conducted secondary subgroup analyses and meta-regression examining the effects of LCPUFA dose and timing, preterm versus term birth status, and trial methodologic quality.

RESULTS

Nineteen studies involving 1949 infants were included. We demonstrated a significant benefit of LCPUFA supplementation on infants' visual acuity at 2, 4, and 12 months of age when visual acuity was assessed by using visual evoked potential and at 2 months of age by using behavioral methods. There was significant heterogeneity between trials but no evidence of publication bias. Secondary analysis failed to show any moderating effects on the association between LCPUFA supplementation and visual acuity.

CONCLUSIONS

Current evidence suggests that LCPUFA supplementation of infant formulas improves infants' visual acuity up to 12 months of age.

Authors+Show Affiliations

Child Study Center and cDepartment of Psychiatry, Yale University, New Haven, Connecticut 06520, USA. michael.bloch@yale.eduNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Meta-Analysis
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

23248232

Citation

Qawasmi, Ahmad, et al. "Meta-analysis of LCPUFA Supplementation of Infant Formula and Visual Acuity." Pediatrics, vol. 131, no. 1, 2013, pp. e262-72.
Qawasmi A, Landeros-Weisenberger A, Bloch MH. Meta-analysis of LCPUFA supplementation of infant formula and visual acuity. Pediatrics. 2013;131(1):e262-72.
Qawasmi, A., Landeros-Weisenberger, A., & Bloch, M. H. (2013). Meta-analysis of LCPUFA supplementation of infant formula and visual acuity. Pediatrics, 131(1), pp. e262-72. doi:10.1542/peds.2012-0517.
Qawasmi A, Landeros-Weisenberger A, Bloch MH. Meta-analysis of LCPUFA Supplementation of Infant Formula and Visual Acuity. Pediatrics. 2013;131(1):e262-72. PubMed PMID: 23248232.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Meta-analysis of LCPUFA supplementation of infant formula and visual acuity. AU - Qawasmi,Ahmad, AU - Landeros-Weisenberger,Angeli, AU - Bloch,Michael H, Y1 - 2012/12/17/ PY - 2012/12/19/entrez PY - 2012/12/19/pubmed PY - 2013/2/23/medline SP - e262 EP - 72 JF - Pediatrics JO - Pediatrics VL - 131 IS - 1 N2 - BACKGROUND AND OBJECTIVE: Long-chain polyunsaturated fatty acids (LCPUFAs) are hypothesized to affect visual acuity development in infants. Randomized controlled trials (RCTs) have been conducted to assess whether supplementation of LCPUFAs of infant formulas affects infant visual acuity. This meta-analysis was conducted to evaluate whether LCPUFA supplementation of infant formulas improves infants' visual acuity. METHODS: PubMed and PsycInfo were searched for RCTs assessing the efficacy of LCPUFA supplementation of infant formulas on infant visual acuity. RCTs assessing the effects of LCPUFA supplementation on visual acuity (by using either visual evoked potential or behavioral methods) in the first year of life were included in this meta-analysis. Our primary outcome was the mean difference in visual resolution acuity (measured in logarithm of minimum angle of resolution [logMAR]) between supplemented and unsupplemented infants. We also conducted secondary subgroup analyses and meta-regression examining the effects of LCPUFA dose and timing, preterm versus term birth status, and trial methodologic quality. RESULTS: Nineteen studies involving 1949 infants were included. We demonstrated a significant benefit of LCPUFA supplementation on infants' visual acuity at 2, 4, and 12 months of age when visual acuity was assessed by using visual evoked potential and at 2 months of age by using behavioral methods. There was significant heterogeneity between trials but no evidence of publication bias. Secondary analysis failed to show any moderating effects on the association between LCPUFA supplementation and visual acuity. CONCLUSIONS: Current evidence suggests that LCPUFA supplementation of infant formulas improves infants' visual acuity up to 12 months of age. SN - 1098-4275 UR - https://www.unboundmedicine.com/medline/citation/23248232/Meta_analysis_of_LCPUFA_supplementation_of_infant_formula_and_visual_acuity_ L2 - http://pediatrics.aappublications.org/cgi/pmidlookup?view=long&pmid=23248232 DB - PRIME DP - Unbound Medicine ER -