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[Peculiarity of the laboratory diagnostic of the measles virus infection in previously vaccinated and unvaccinated patients].
Vopr Virusol. 2012 Sep-Oct; 57(5):21-6.VV

Abstract

119 specimens of blood sera collected from measles cases with different vaccination history (aged 4 months to 48 years) on 5th-6th days after rash onset were Investigated using EIA. The obtained results showed that the primary immune response (PIR) was developed in 59 patients; the secondary immune response (SIR) was developed in 60 patients with a significant increase in the specific high avidity IgG (22.34 IU/ml +/- 3.2). The specific IgM were detected in 100% cases studied with capture ELISA in both previously vaccinated and unvaccinated individuals of different age. The specific IgM were detected by indirect ELISA in 100% cases in unvaccinated patients, while IgM positive sera was defined only in 23.3% of individuals with SIR. It was concluded that measles virus infection in previously vaccinated and unvaccinated adults had clinical differences. The role of patients with SIR in virus transmission was discussed.

Authors

Mamaeva TA
No affiliation info available
Lipskaia GIu
No affiliation info available
Naumova MA
No affiliation info available
Shul'ga SV
No affiliation info available
Mulders M
No affiliation info available
Featherstone DA
No affiliation info available
Zav'ialova LA
No affiliation info available
Chernysheva EV
No affiliation info available
Zamiatina EP
No affiliation info available
Kuznetsova NN
No affiliation info available

MeSH

AdolescentAdultChildChild, PreschoolEnzyme-Linked Immunosorbent AssayHumansImmunoglobulin GImmunoglobulin MInfantMeaslesMeasles VaccineMeasles virusMiddle AgedVaccination

Pub Type(s)

English Abstract
Journal Article

Language

rus

PubMed ID

23248855

Citation

Mamaeva, T A., et al. "[Peculiarity of the Laboratory Diagnostic of the Measles Virus Infection in Previously Vaccinated and Unvaccinated Patients]." Voprosy Virusologii, vol. 57, no. 5, 2012, pp. 21-6.
Mamaeva TA, Lipskaia GIu, Naumova MA, et al. [Peculiarity of the laboratory diagnostic of the measles virus infection in previously vaccinated and unvaccinated patients]. Vopr Virusol. 2012;57(5):21-6.
Mamaeva, T. A., Lipskaia, G. I. u., Naumova, M. A., Shul'ga, S. V., Mulders, M., Featherstone, D. A., Zav'ialova, L. A., Chernysheva, E. V., Zamiatina, E. P., & Kuznetsova, N. N. (2012). [Peculiarity of the laboratory diagnostic of the measles virus infection in previously vaccinated and unvaccinated patients]. Voprosy Virusologii, 57(5), 21-6.
Mamaeva TA, et al. [Peculiarity of the Laboratory Diagnostic of the Measles Virus Infection in Previously Vaccinated and Unvaccinated Patients]. Vopr Virusol. 2012 Sep-Oct;57(5):21-6. PubMed PMID: 23248855.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - [Peculiarity of the laboratory diagnostic of the measles virus infection in previously vaccinated and unvaccinated patients]. AU - Mamaeva,T A, AU - Lipskaia,G Iu, AU - Naumova,M A, AU - Shul'ga,S V, AU - Mulders,M, AU - Featherstone,D A, AU - Zav'ialova,L A, AU - Chernysheva,E V, AU - Zamiatina,E P, AU - Kuznetsova,N N, PY - 2012/12/20/entrez PY - 2012/12/20/pubmed PY - 2013/2/14/medline SP - 21 EP - 6 JF - Voprosy virusologii JO - Vopr Virusol VL - 57 IS - 5 N2 - 119 specimens of blood sera collected from measles cases with different vaccination history (aged 4 months to 48 years) on 5th-6th days after rash onset were Investigated using EIA. The obtained results showed that the primary immune response (PIR) was developed in 59 patients; the secondary immune response (SIR) was developed in 60 patients with a significant increase in the specific high avidity IgG (22.34 IU/ml +/- 3.2). The specific IgM were detected in 100% cases studied with capture ELISA in both previously vaccinated and unvaccinated individuals of different age. The specific IgM were detected by indirect ELISA in 100% cases in unvaccinated patients, while IgM positive sera was defined only in 23.3% of individuals with SIR. It was concluded that measles virus infection in previously vaccinated and unvaccinated adults had clinical differences. The role of patients with SIR in virus transmission was discussed. SN - 0507-4088 UR - https://www.unboundmedicine.com/medline/citation/23248855/[Peculiarity_of_the_laboratory_diagnostic_of_the_measles_virus_infection_in_previously_vaccinated_and_unvaccinated_patients]_ L2 - http://www.diseaseinfosearch.org/result/4535 DB - PRIME DP - Unbound Medicine ER -