Tags

Type your tag names separated by a space and hit enter

Prostaglandin and fatty acid metabolism in patients with extrahepatic biliary atresia.
J Pediatr Gastroenterol Nutr. 1990 Apr; 10(3):298-302.JP

Abstract

The relationship between essential fatty acid (EFA) deficiency and disturbance of prostaglandin (PG) biosynthesis was studied in children after radical operation for extrahepatic biliary atresia (EBA). In addition, to investigate the method for treatment of postoperative EFA deficiency and disturbance of PG biosynthesis, the serum fatty acid and plasma PG levels were determined before and after supplementation of an EFA-rich powder (38 g of linoleic acid per 100 g of powder) through Suruga II enterostomy. Before administration of the EFA-rich powder, linoleic acid, arachidonic acid, PGE1, and PGF2 alpha levels were significantly lower in both good bile excretion and poor bile excretion groups than in the control group. After administration, linoleic acid and PGE1 levels significantly increased in the good bile excretion group as compared with the preadministration values. These results suggest that the supplementation of EFA-rich powder is an effective treatment for linoleic acid deficiency and disturbance of PGE1 biosynthesis in postoperative EBA patients.

Authors+Show Affiliations

Department of Pediatrics, Juntendo University School of Medicine, Tokyo, Japan.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

2324889

Citation

Shimizu, T, et al. "Prostaglandin and Fatty Acid Metabolism in Patients With Extrahepatic Biliary Atresia." Journal of Pediatric Gastroenterology and Nutrition, vol. 10, no. 3, 1990, pp. 298-302.
Shimizu T, Yamashiro Y, Yabuta K, et al. Prostaglandin and fatty acid metabolism in patients with extrahepatic biliary atresia. J Pediatr Gastroenterol Nutr. 1990;10(3):298-302.
Shimizu, T., Yamashiro, Y., Yabuta, K., Miyano, T., & Hayasawa, H. (1990). Prostaglandin and fatty acid metabolism in patients with extrahepatic biliary atresia. Journal of Pediatric Gastroenterology and Nutrition, 10(3), 298-302.
Shimizu T, et al. Prostaglandin and Fatty Acid Metabolism in Patients With Extrahepatic Biliary Atresia. J Pediatr Gastroenterol Nutr. 1990;10(3):298-302. PubMed PMID: 2324889.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Prostaglandin and fatty acid metabolism in patients with extrahepatic biliary atresia. AU - Shimizu,T, AU - Yamashiro,Y, AU - Yabuta,K, AU - Miyano,T, AU - Hayasawa,H, PY - 1990/4/1/pubmed PY - 1990/4/1/medline PY - 1990/4/1/entrez SP - 298 EP - 302 JF - Journal of pediatric gastroenterology and nutrition JO - J Pediatr Gastroenterol Nutr VL - 10 IS - 3 N2 - The relationship between essential fatty acid (EFA) deficiency and disturbance of prostaglandin (PG) biosynthesis was studied in children after radical operation for extrahepatic biliary atresia (EBA). In addition, to investigate the method for treatment of postoperative EFA deficiency and disturbance of PG biosynthesis, the serum fatty acid and plasma PG levels were determined before and after supplementation of an EFA-rich powder (38 g of linoleic acid per 100 g of powder) through Suruga II enterostomy. Before administration of the EFA-rich powder, linoleic acid, arachidonic acid, PGE1, and PGF2 alpha levels were significantly lower in both good bile excretion and poor bile excretion groups than in the control group. After administration, linoleic acid and PGE1 levels significantly increased in the good bile excretion group as compared with the preadministration values. These results suggest that the supplementation of EFA-rich powder is an effective treatment for linoleic acid deficiency and disturbance of PGE1 biosynthesis in postoperative EBA patients. SN - 0277-2116 UR - https://www.unboundmedicine.com/medline/citation/2324889/Prostaglandin_and_fatty_acid_metabolism_in_patients_with_extrahepatic_biliary_atresia_ L2 - http://ovidsp.ovid.com/ovidweb.cgi?T=JS&PAGE=linkout&SEARCH=2324889.ui DB - PRIME DP - Unbound Medicine ER -