Tags

Type your tag names separated by a space and hit enter

Lower short- and long-term mortality associated with overweight and obesity in a large cohort study of adult intensive care unit patients.
Crit Care. 2012 Dec 18; 16(6):R235.CC

Abstract

INTRODUCTION

Two thirds of United States adults are overweight or obese, which puts them at higher risk of developing chronic diseases and of death compared with normal-weight individuals. However, recent studies have found that overweight and obesity by themselves may be protective in some contexts, such as hospitalization in an intensive care unit (ICU). Our objective was to determine the relation between body mass index (BMI) and mortality at 30 days and 1 year after ICU admission.

METHODS

We performed a cohort analysis of 16,812 adult patients from MIMIC-II, a large database of ICU patients at a tertiary care hospital in Boston, Massachusetts. The data were originally collected during the course of clinical care, and we subsequently extracted our dataset independent of the study outcome.

RESULTS

Compared with normal-weight patients, obese patients had 26% and 43% lower mortality risk at 30 days and 1 year after ICU admission, respectively (odds ratio (OR), 0.74; 95% confidence interval (CI), 0.64 to 0.86) and 0.57 (95% CI, 0.49 to 0.67)); overweight patients had nearly 20% and 30% lower mortality risk (OR, 0.81; 95% CI, 0.70 to 0.93) and OR, 0.68 (95% CI, 0.59 to 0.79)). Severely obese patients (BMI ≥ 40 kg/m2) did not have a significant survival advantage at 30 days (OR, 0.94; 95% CI, 0.74 to 1.20), but did have 30% lower mortality risk at 1 year (OR, 0.70 (95% CI, 0.54 to 0.90)). No significant difference in admission acuity or ICU and hospital length of stay was found across BMI categories.

CONCLUSION

Our study supports the hypothesis that patients who are overweight or obese have improved survival both 30 days and 1 year after ICU admission.

Authors

No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, N.I.H., Intramural

Language

eng

PubMed ID

23249446

Citation

Abhyankar, Swapna, et al. "Lower Short- and Long-term Mortality Associated With Overweight and Obesity in a Large Cohort Study of Adult Intensive Care Unit Patients." Critical Care (London, England), vol. 16, no. 6, 2012, pp. R235.
Abhyankar S, Leishear K, Callaghan FM, et al. Lower short- and long-term mortality associated with overweight and obesity in a large cohort study of adult intensive care unit patients. Crit Care. 2012;16(6):R235.
Abhyankar, S., Leishear, K., Callaghan, F. M., Demner-Fushman, D., & McDonald, C. J. (2012). Lower short- and long-term mortality associated with overweight and obesity in a large cohort study of adult intensive care unit patients. Critical Care (London, England), 16(6), R235. https://doi.org/10.1186/cc11903
Abhyankar S, et al. Lower Short- and Long-term Mortality Associated With Overweight and Obesity in a Large Cohort Study of Adult Intensive Care Unit Patients. Crit Care. 2012 Dec 18;16(6):R235. PubMed PMID: 23249446.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Lower short- and long-term mortality associated with overweight and obesity in a large cohort study of adult intensive care unit patients. AU - Abhyankar,Swapna, AU - Leishear,Kira, AU - Callaghan,Fiona M, AU - Demner-Fushman,Dina, AU - McDonald,Clement J, Y1 - 2012/12/18/ PY - 2012/08/02/received PY - 2012/12/13/accepted PY - 2012/12/20/entrez PY - 2012/12/20/pubmed PY - 2015/10/1/medline SP - R235 EP - R235 JF - Critical care (London, England) JO - Crit Care VL - 16 IS - 6 N2 - INTRODUCTION: Two thirds of United States adults are overweight or obese, which puts them at higher risk of developing chronic diseases and of death compared with normal-weight individuals. However, recent studies have found that overweight and obesity by themselves may be protective in some contexts, such as hospitalization in an intensive care unit (ICU). Our objective was to determine the relation between body mass index (BMI) and mortality at 30 days and 1 year after ICU admission. METHODS: We performed a cohort analysis of 16,812 adult patients from MIMIC-II, a large database of ICU patients at a tertiary care hospital in Boston, Massachusetts. The data were originally collected during the course of clinical care, and we subsequently extracted our dataset independent of the study outcome. RESULTS: Compared with normal-weight patients, obese patients had 26% and 43% lower mortality risk at 30 days and 1 year after ICU admission, respectively (odds ratio (OR), 0.74; 95% confidence interval (CI), 0.64 to 0.86) and 0.57 (95% CI, 0.49 to 0.67)); overweight patients had nearly 20% and 30% lower mortality risk (OR, 0.81; 95% CI, 0.70 to 0.93) and OR, 0.68 (95% CI, 0.59 to 0.79)). Severely obese patients (BMI ≥ 40 kg/m2) did not have a significant survival advantage at 30 days (OR, 0.94; 95% CI, 0.74 to 1.20), but did have 30% lower mortality risk at 1 year (OR, 0.70 (95% CI, 0.54 to 0.90)). No significant difference in admission acuity or ICU and hospital length of stay was found across BMI categories. CONCLUSION: Our study supports the hypothesis that patients who are overweight or obese have improved survival both 30 days and 1 year after ICU admission. SN - 1466-609X UR - https://www.unboundmedicine.com/medline/citation/23249446/Lower_short__and_long_term_mortality_associated_with_overweight_and_obesity_in_a_large_cohort_study_of_adult_intensive_care_unit_patients_ L2 - https://ccforum.biomedcentral.com/articles/10.1186/cc11903 DB - PRIME DP - Unbound Medicine ER -