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Estimation of salivary nitric oxide in recurrent aphthous ulcer and oral lichen planus patients with its clinical significance.
J Contemp Dent Pract. 2012 Sep 01; 13(5):623-6.JC

Abstract

AIM

The present study was undertaken to study the role of nitric oxide in human saliva and its diagnostic/prognostic role in recurrent aphthous ulcers (RAU) and oral lichen planus (OLP).

MATERIALS AND METHODS

The study was carried out at outpatient department of Govt Dental College and Hospital, Aurangabad. Twenty cases with RAU, 15 with OLP and 30 healthy individuals were included in the study. The clinically diagnosed known cases of RAU and OLP were included after taking the detail case history and subjected to blood analysis for hemogram and biochemically salivary nitric oxide was estimated.

RESULTS

The salivary nitric oxide levels were found to be increased significantly in RAU and OLP group, when compared with controls. Further, significantly increased levels have been observed in OLP group, when compared with RAU group (p < 0.001). The salivary nitric oxide levels were found to be increased significantly in minor RAU than major RAU and increased in erosive type of OLP than nonerosive type of OLP.

CONCLUSION

Thus, salivary nitric oxide can be treated as a diagnostic tool for the differential diagnosis of RAU and OLP.

CLINICAL SIGNIFICANCE

Nitric oxide plays an important role in modifying physiopathological processes of oral mucosal membrane so has diagnostic as well as prognostic value.

Authors+Show Affiliations

Department of Oral Pathology and Microbiology, Yashwantrao Chavan Dental College, Ahmednagar, Maharashtra, India. dr_kiranjagtap@rediffmail.comNo affiliation info available

Pub Type(s)

Comparative Study
Journal Article

Language

eng

PubMed ID

23250164

Citation

Jagtap, Kiran, and R K. Baad. "Estimation of Salivary Nitric Oxide in Recurrent Aphthous Ulcer and Oral Lichen Planus Patients With Its Clinical Significance." The Journal of Contemporary Dental Practice, vol. 13, no. 5, 2012, pp. 623-6.
Jagtap K, Baad RK. Estimation of salivary nitric oxide in recurrent aphthous ulcer and oral lichen planus patients with its clinical significance. J Contemp Dent Pract. 2012;13(5):623-6.
Jagtap, K., & Baad, R. K. (2012). Estimation of salivary nitric oxide in recurrent aphthous ulcer and oral lichen planus patients with its clinical significance. The Journal of Contemporary Dental Practice, 13(5), 623-6.
Jagtap K, Baad RK. Estimation of Salivary Nitric Oxide in Recurrent Aphthous Ulcer and Oral Lichen Planus Patients With Its Clinical Significance. J Contemp Dent Pract. 2012 Sep 1;13(5):623-6. PubMed PMID: 23250164.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Estimation of salivary nitric oxide in recurrent aphthous ulcer and oral lichen planus patients with its clinical significance. AU - Jagtap,Kiran, AU - Baad,R K, Y1 - 2012/09/01/ PY - 2012/12/20/entrez PY - 2012/12/20/pubmed PY - 2013/5/28/medline SP - 623 EP - 6 JF - The journal of contemporary dental practice JO - J Contemp Dent Pract VL - 13 IS - 5 N2 - AIM: The present study was undertaken to study the role of nitric oxide in human saliva and its diagnostic/prognostic role in recurrent aphthous ulcers (RAU) and oral lichen planus (OLP). MATERIALS AND METHODS: The study was carried out at outpatient department of Govt Dental College and Hospital, Aurangabad. Twenty cases with RAU, 15 with OLP and 30 healthy individuals were included in the study. The clinically diagnosed known cases of RAU and OLP were included after taking the detail case history and subjected to blood analysis for hemogram and biochemically salivary nitric oxide was estimated. RESULTS: The salivary nitric oxide levels were found to be increased significantly in RAU and OLP group, when compared with controls. Further, significantly increased levels have been observed in OLP group, when compared with RAU group (p < 0.001). The salivary nitric oxide levels were found to be increased significantly in minor RAU than major RAU and increased in erosive type of OLP than nonerosive type of OLP. CONCLUSION: Thus, salivary nitric oxide can be treated as a diagnostic tool for the differential diagnosis of RAU and OLP. CLINICAL SIGNIFICANCE: Nitric oxide plays an important role in modifying physiopathological processes of oral mucosal membrane so has diagnostic as well as prognostic value. SN - 1526-3711 UR - https://www.unboundmedicine.com/medline/citation/23250164/Estimation_of_salivary_nitric_oxide_in_recurrent_aphthous_ulcer_and_oral_lichen_planus_patients_with_its_clinical_significance_ L2 - http://www.diseaseinfosearch.org/result/5399 DB - PRIME DP - Unbound Medicine ER -