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Evaluation of percutaneous absorption of esculetin: effect of chemical enhancers.
Planta Med. 2013 Jan; 79(2):131-6.PM

Abstract

Percutaneous transdermal absorption of esculetin (6,7-dihydroxycoumarin), an oxidative damage inhibitor, was evaluated by means of in vitro permeation studies in which vertical Franz-type diffusion cells and pig ear skin were employed. To determine the absorption of esculetin, we validated a simple, accurate, precise, and rapid HPLC-UV method. Additionally, the effects of several percutaneous enhancers were studied. Pretreatment of porcine skin was performed with ethanol (control vehicle), decenoic acid, oleic acid, R-(+)-limonene, and laurocapram (Azone®) (5% in ethanol, w/w, respectively). Pretreatment of skin with oleic acid or laurocapram led to statistically significant differences in the transdermal flux of esculetin with respect to controls. Of the two enhancers, laurocapram showed the greatest capacity to enhance the flux of esculetin across pig skin.

Authors+Show Affiliations

Instituto de Ciencias Biomédicas, Departamento de Farmacia, Facultad de Ciencias de la Salud, Universidad CEU Cardenal Herrera, Valencia, Spain.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

23250808

Citation

del Rio Sancho, Sergio, et al. "Evaluation of Percutaneous Absorption of Esculetin: Effect of Chemical Enhancers." Planta Medica, vol. 79, no. 2, 2013, pp. 131-6.
del Rio Sancho S, Serna Jiménez CE, Calatayud Pascual MA, et al. Evaluation of percutaneous absorption of esculetin: effect of chemical enhancers. Planta Med. 2013;79(2):131-6.
del Rio Sancho, S., Serna Jiménez, C. E., Calatayud Pascual, M. A., Balaguer Fernández, C., Femenía Font, A., Castillo García, E., Merino, V., & López Castellano, A. (2013). Evaluation of percutaneous absorption of esculetin: effect of chemical enhancers. Planta Medica, 79(2), 131-6. https://doi.org/10.1055/s-0032-1328058
del Rio Sancho S, et al. Evaluation of Percutaneous Absorption of Esculetin: Effect of Chemical Enhancers. Planta Med. 2013;79(2):131-6. PubMed PMID: 23250808.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Evaluation of percutaneous absorption of esculetin: effect of chemical enhancers. AU - del Rio Sancho,Sergio, AU - Serna Jiménez,César Eulogio, AU - Calatayud Pascual,María Aracely, AU - Balaguer Fernández,Cristina, AU - Femenía Font,Andrés, AU - Castillo García,Encarna, AU - Merino,Virginia, AU - López Castellano,Alicia, Y1 - 2012/12/18/ PY - 2012/12/20/entrez PY - 2012/12/20/pubmed PY - 2013/7/17/medline SP - 131 EP - 6 JF - Planta medica JO - Planta Med VL - 79 IS - 2 N2 - Percutaneous transdermal absorption of esculetin (6,7-dihydroxycoumarin), an oxidative damage inhibitor, was evaluated by means of in vitro permeation studies in which vertical Franz-type diffusion cells and pig ear skin were employed. To determine the absorption of esculetin, we validated a simple, accurate, precise, and rapid HPLC-UV method. Additionally, the effects of several percutaneous enhancers were studied. Pretreatment of porcine skin was performed with ethanol (control vehicle), decenoic acid, oleic acid, R-(+)-limonene, and laurocapram (Azone®) (5% in ethanol, w/w, respectively). Pretreatment of skin with oleic acid or laurocapram led to statistically significant differences in the transdermal flux of esculetin with respect to controls. Of the two enhancers, laurocapram showed the greatest capacity to enhance the flux of esculetin across pig skin. SN - 1439-0221 UR - https://www.unboundmedicine.com/medline/citation/23250808/Evaluation_of_percutaneous_absorption_of_esculetin:_effect_of_chemical_enhancers_ L2 - http://www.thieme-connect.com/DOI/DOI?10.1055/s-0032-1328058 DB - PRIME DP - Unbound Medicine ER -