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Blunted neural response to rewards prospectively predicts depression in adolescent girls.
Psychophysiology. 2013 Jan; 50(1):74-81.P

Abstract

The prevalence of depression increases substantially during adolescence. Several predictors of major depressive disorder have been established, but their predictive power is limited. In the current study, the feedback negativity (FN), an event-related potential component elicited by feedback indicating monetary gain versus loss, was recorded in 68 never-depressed adolescent girls. Over the following 2 years, 24% of participants developed a major depressive episode (MDE); illness onset was predicted by blunted FN at initial evaluation. Lower FN amplitude predicted more depressive symptoms during the follow-up period, even after controlling for neuroticism and depressive symptoms at baseline. This is the first prospective study to demonstrate a link between a neural measure of reward sensitivity and the first onset of an MDE. The current results suggest that low reward sensitivity may be an important factor in the development of depression.

Authors+Show Affiliations

Department of Psychology, Stony Brook University, Stony Brook, New York, USA.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

23252717

Citation

Bress, Jennifer N., et al. "Blunted Neural Response to Rewards Prospectively Predicts Depression in Adolescent Girls." Psychophysiology, vol. 50, no. 1, 2013, pp. 74-81.
Bress JN, Foti D, Kotov R, et al. Blunted neural response to rewards prospectively predicts depression in adolescent girls. Psychophysiology. 2013;50(1):74-81.
Bress, J. N., Foti, D., Kotov, R., Klein, D. N., & Hajcak, G. (2013). Blunted neural response to rewards prospectively predicts depression in adolescent girls. Psychophysiology, 50(1), 74-81. https://doi.org/10.1111/j.1469-8986.2012.01485.x
Bress JN, et al. Blunted Neural Response to Rewards Prospectively Predicts Depression in Adolescent Girls. Psychophysiology. 2013;50(1):74-81. PubMed PMID: 23252717.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Blunted neural response to rewards prospectively predicts depression in adolescent girls. AU - Bress,Jennifer N, AU - Foti,Dan, AU - Kotov,Roman, AU - Klein,Daniel N, AU - Hajcak,Greg, PY - 2012/04/19/received PY - 2012/09/18/accepted PY - 2012/12/21/entrez PY - 2012/12/21/pubmed PY - 2013/11/20/medline SP - 74 EP - 81 JF - Psychophysiology JO - Psychophysiology VL - 50 IS - 1 N2 - The prevalence of depression increases substantially during adolescence. Several predictors of major depressive disorder have been established, but their predictive power is limited. In the current study, the feedback negativity (FN), an event-related potential component elicited by feedback indicating monetary gain versus loss, was recorded in 68 never-depressed adolescent girls. Over the following 2 years, 24% of participants developed a major depressive episode (MDE); illness onset was predicted by blunted FN at initial evaluation. Lower FN amplitude predicted more depressive symptoms during the follow-up period, even after controlling for neuroticism and depressive symptoms at baseline. This is the first prospective study to demonstrate a link between a neural measure of reward sensitivity and the first onset of an MDE. The current results suggest that low reward sensitivity may be an important factor in the development of depression. SN - 1540-5958 UR - https://www.unboundmedicine.com/medline/citation/23252717/Blunted_neural_response_to_rewards_prospectively_predicts_depression_in_adolescent_girls_ L2 - https://doi.org/10.1111/j.1469-8986.2012.01485.x DB - PRIME DP - Unbound Medicine ER -