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Long-term treatment with resveratrol attenuates oxidative stress pro-inflammatory mediators and apoptosis in streptozotocin-nicotinamide-induced diabetic rats.
Gen Physiol Biophys. 2012 Dec; 31(4):431-8.GP

Abstract

This study was designed to investigate the possible effectiveness of chronic resveratrol administration on redox state, inflammatory mediators and apoptosis rate in diabetic rats. Male Wistar rats were divided into four groups (n = 6): normal control, diabetic control, normal rats treated with resveratrol, and diabetic rats treated with resveratrol. Diabetes was induced by injection of streptozotocin (50 mg/kg; i.p.), 15 min after the prescription of nicotinamide (110 mg/kg; i.p.) in 12 h-fasted rats. Four-month oral resveratrol administration (5 mg/kg/day) significantly alleviated hyperglycemia, weight loss, enhancement of oxidative markers (lipid peroxidation index, nitrite/nitrate content and oxidized to reduced glutathione ratio) and superoxide dismutase activity in diabetic rats. Moreover, resveratrol administration to diabetic rats improved the elevated levels of plasma TNFα and IL-6 as well as NF-κB activity of polymorphonuclear cells. On the other hand, four months resveratrol administration decreased the apoptosis rate in the kidney, heart, retina, sciatic nerve and the polymorphonuclear cells of diabetic rats. These beneficial antidiabetic observations suggest that treatment with resveratrol may be considered as a therapeutic approach to reduce diabetic-related complications.

Authors+Show Affiliations

Department of Physiology, Faculty of Medicine, Hormozgan University of Medical Sciences, Bandar Abbas, Iran.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

23255670

Citation

Soufi, Farhad Ghadiri, et al. "Long-term Treatment With Resveratrol Attenuates Oxidative Stress Pro-inflammatory Mediators and Apoptosis in Streptozotocin-nicotinamide-induced Diabetic Rats." General Physiology and Biophysics, vol. 31, no. 4, 2012, pp. 431-8.
Soufi FG, Vardyani M, Sheervalilou R, et al. Long-term treatment with resveratrol attenuates oxidative stress pro-inflammatory mediators and apoptosis in streptozotocin-nicotinamide-induced diabetic rats. Gen Physiol Biophys. 2012;31(4):431-8.
Soufi, F. G., Vardyani, M., Sheervalilou, R., Mohammadi, M., & Somi, M. H. (2012). Long-term treatment with resveratrol attenuates oxidative stress pro-inflammatory mediators and apoptosis in streptozotocin-nicotinamide-induced diabetic rats. General Physiology and Biophysics, 31(4), 431-8. https://doi.org/10.4149/gpb_2012_039
Soufi FG, et al. Long-term Treatment With Resveratrol Attenuates Oxidative Stress Pro-inflammatory Mediators and Apoptosis in Streptozotocin-nicotinamide-induced Diabetic Rats. Gen Physiol Biophys. 2012;31(4):431-8. PubMed PMID: 23255670.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Long-term treatment with resveratrol attenuates oxidative stress pro-inflammatory mediators and apoptosis in streptozotocin-nicotinamide-induced diabetic rats. AU - Soufi,Farhad Ghadiri, AU - Vardyani,Mina, AU - Sheervalilou,Roghayeh, AU - Mohammadi,Mustafa, AU - Somi,Mohammad Hussein, PY - 2012/12/21/entrez PY - 2012/12/21/pubmed PY - 2013/3/8/medline SP - 431 EP - 8 JF - General physiology and biophysics JO - Gen Physiol Biophys VL - 31 IS - 4 N2 - This study was designed to investigate the possible effectiveness of chronic resveratrol administration on redox state, inflammatory mediators and apoptosis rate in diabetic rats. Male Wistar rats were divided into four groups (n = 6): normal control, diabetic control, normal rats treated with resveratrol, and diabetic rats treated with resveratrol. Diabetes was induced by injection of streptozotocin (50 mg/kg; i.p.), 15 min after the prescription of nicotinamide (110 mg/kg; i.p.) in 12 h-fasted rats. Four-month oral resveratrol administration (5 mg/kg/day) significantly alleviated hyperglycemia, weight loss, enhancement of oxidative markers (lipid peroxidation index, nitrite/nitrate content and oxidized to reduced glutathione ratio) and superoxide dismutase activity in diabetic rats. Moreover, resveratrol administration to diabetic rats improved the elevated levels of plasma TNFα and IL-6 as well as NF-κB activity of polymorphonuclear cells. On the other hand, four months resveratrol administration decreased the apoptosis rate in the kidney, heart, retina, sciatic nerve and the polymorphonuclear cells of diabetic rats. These beneficial antidiabetic observations suggest that treatment with resveratrol may be considered as a therapeutic approach to reduce diabetic-related complications. SN - 0231-5882 UR - https://www.unboundmedicine.com/medline/citation/23255670/Long_term_treatment_with_resveratrol_attenuates_oxidative_stress_pro_inflammatory_mediators_and_apoptosis_in_streptozotocin_nicotinamide_induced_diabetic_rats_ L2 - http://www.aepress.sk/_downloads/dl.php?from=pubmed&journal=GPB&file=2012_04_431.pdf DB - PRIME DP - Unbound Medicine ER -