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Meta-analysis investigating associations between healthy diet and fasting glucose and insulin levels and modification by loci associated with glucose homeostasis in data from 15 cohorts.
Am J Epidemiol 2013; 177(2):103-15AJ

Abstract

Whether loci that influence fasting glucose (FG) and fasting insulin (FI) levels, as identified by genome-wide association studies, modify associations of diet with FG or FI is unknown. We utilized data from 15 U.S. and European cohort studies comprising 51,289 persons without diabetes to test whether genotype and diet interact to influence FG or FI concentration. We constructed a diet score using study-specific quartile rankings for intakes of whole grains, fish, fruits, vegetables, and nuts/seeds (favorable) and red/processed meats, sweets, sugared beverages, and fried potatoes (unfavorable). We used linear regression within studies, followed by inverse-variance-weighted meta-analysis, to quantify 1) associations of diet score with FG and FI levels and 2) interactions of diet score with 16 FG-associated loci and 2 FI-associated loci. Diet score (per unit increase) was inversely associated with FG (β = -0.004 mmol/L, 95% confidence interval: -0.005, -0.003) and FI (β = -0.008 ln-pmol/L, 95% confidence interval: -0.009, -0.007) levels after adjustment for demographic factors, lifestyle, and body mass index. Genotype variation at the studied loci did not modify these associations. Healthier diets were associated with lower FG and FI concentrations regardless of genotype at previously replicated FG- and FI-associated loci. Studies focusing on genomic regions that do not yield highly statistically significant associations from main-effect genome-wide association studies may be more fruitful in identifying diet-gene interactions.

Authors+Show Affiliations

Division of Epidemiology, Human Genetics and Environmental Sciences, School of Public Health, University of Texas Health Science Center at Houston, 1200 Herman Pressler Drive, Suite E-641, Houston, TX 77030, USA. jennifer.a.nettleton@uth.tmc.eduNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Meta-Analysis
Review

Language

eng

PubMed ID

23255780

Citation

Nettleton, Jennifer A., et al. "Meta-analysis Investigating Associations Between Healthy Diet and Fasting Glucose and Insulin Levels and Modification By Loci Associated With Glucose Homeostasis in Data From 15 Cohorts." American Journal of Epidemiology, vol. 177, no. 2, 2013, pp. 103-15.
Nettleton JA, Hivert MF, Lemaitre RN, et al. Meta-analysis investigating associations between healthy diet and fasting glucose and insulin levels and modification by loci associated with glucose homeostasis in data from 15 cohorts. Am J Epidemiol. 2013;177(2):103-15.
Nettleton, J. A., Hivert, M. F., Lemaitre, R. N., McKeown, N. M., Mozaffarian, D., Tanaka, T., ... Franks, P. W. (2013). Meta-analysis investigating associations between healthy diet and fasting glucose and insulin levels and modification by loci associated with glucose homeostasis in data from 15 cohorts. American Journal of Epidemiology, 177(2), pp. 103-15. doi:10.1093/aje/kws297.
Nettleton JA, et al. Meta-analysis Investigating Associations Between Healthy Diet and Fasting Glucose and Insulin Levels and Modification By Loci Associated With Glucose Homeostasis in Data From 15 Cohorts. Am J Epidemiol. 2013 Jan 15;177(2):103-15. PubMed PMID: 23255780.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Meta-analysis investigating associations between healthy diet and fasting glucose and insulin levels and modification by loci associated with glucose homeostasis in data from 15 cohorts. AU - Nettleton,Jennifer A, AU - Hivert,Marie-France, AU - Lemaitre,Rozenn N, AU - McKeown,Nicola M, AU - Mozaffarian,Dariush, AU - Tanaka,Toshiko, AU - Wojczynski,Mary K, AU - Hruby,Adela, AU - Djoussé,Luc, AU - Ngwa,Julius S, AU - Follis,Jack L, AU - Dimitriou,Maria, AU - Ganna,Andrea, AU - Houston,Denise K, AU - Kanoni,Stavroula, AU - Mikkilä,Vera, AU - Manichaikul,Ani, AU - Ntalla,Ioanna, AU - Renström,Frida, AU - Sonestedt,Emily, AU - van Rooij,Frank J A, AU - Bandinelli,Stefania, AU - de Koning,Lawrence, AU - Ericson,Ulrika, AU - Hassanali,Neelam, AU - Kiefte-de Jong,Jessica C, AU - Lohman,Kurt K, AU - Raitakari,Olli, AU - Papoutsakis,Constantina, AU - Sjogren,Per, AU - Stirrups,Kathleen, AU - Ax,Erika, AU - Deloukas,Panos, AU - Groves,Christopher J, AU - Jacques,Paul F, AU - Johansson,Ingegerd, AU - Liu,Yongmei, AU - McCarthy,Mark I, AU - North,Kari, AU - Viikari,Jorma, AU - Zillikens,M Carola, AU - Dupuis,Josée, AU - Hofman,Albert, AU - Kolovou,Genovefa, AU - Mukamal,Kenneth, AU - Prokopenko,Inga, AU - Rolandsson,Olov, AU - Seppälä,Ilkka, AU - Cupples,L Adrienne, AU - Hu,Frank B, AU - Kähönen,Mika, AU - Uitterlinden,André G, AU - Borecki,Ingrid B, AU - Ferrucci,Luigi, AU - Jacobs,David R,Jr AU - Kritchevsky,Stephen B, AU - Orho-Melander,Marju, AU - Pankow,James S, AU - Lehtimäki,Terho, AU - Witteman,Jacqueline C M, AU - Ingelsson,Erik, AU - Siscovick,David S, AU - Dedoussis,George, AU - Meigs,James B, AU - Franks,Paul W, Y1 - 2012/12/19/ PY - 2012/12/21/entrez PY - 2012/12/21/pubmed PY - 2013/3/5/medline SP - 103 EP - 15 JF - American journal of epidemiology JO - Am. J. Epidemiol. VL - 177 IS - 2 N2 - Whether loci that influence fasting glucose (FG) and fasting insulin (FI) levels, as identified by genome-wide association studies, modify associations of diet with FG or FI is unknown. We utilized data from 15 U.S. and European cohort studies comprising 51,289 persons without diabetes to test whether genotype and diet interact to influence FG or FI concentration. We constructed a diet score using study-specific quartile rankings for intakes of whole grains, fish, fruits, vegetables, and nuts/seeds (favorable) and red/processed meats, sweets, sugared beverages, and fried potatoes (unfavorable). We used linear regression within studies, followed by inverse-variance-weighted meta-analysis, to quantify 1) associations of diet score with FG and FI levels and 2) interactions of diet score with 16 FG-associated loci and 2 FI-associated loci. Diet score (per unit increase) was inversely associated with FG (β = -0.004 mmol/L, 95% confidence interval: -0.005, -0.003) and FI (β = -0.008 ln-pmol/L, 95% confidence interval: -0.009, -0.007) levels after adjustment for demographic factors, lifestyle, and body mass index. Genotype variation at the studied loci did not modify these associations. Healthier diets were associated with lower FG and FI concentrations regardless of genotype at previously replicated FG- and FI-associated loci. Studies focusing on genomic regions that do not yield highly statistically significant associations from main-effect genome-wide association studies may be more fruitful in identifying diet-gene interactions. SN - 1476-6256 UR - https://www.unboundmedicine.com/medline/citation/23255780/Meta_analysis_investigating_associations_between_healthy_diet_and_fasting_glucose_and_insulin_levels_and_modification_by_loci_associated_with_glucose_homeostasis_in_data_from_15_cohorts_ L2 - https://academic.oup.com/aje/article-lookup/doi/10.1093/aje/kws297 DB - PRIME DP - Unbound Medicine ER -