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[Plasma and tumor gastrin in patients with primary hyperparathyroidism].
Nihon Geka Gakkai Zasshi. 1990 Feb; 91(2):262-5.NG

Abstract

It is well known that primary hyperparathyroidism is often associated with peptic ulcer. The purpose of this study is to confirm the relationship between the gastrin-levels before and after parathyroidectomy in fourteen patients with primary hyperparathyroidism, and to determine the localization of gastrin in the surgically resected parathyroid tumor. The results obtained were as follows: 1) Three patients had peptic ulcer (gastric ulcer and duodenal ulcer), the incidence being 21%. 2) The basal serum gastrin levels were 123.0% +/- 68.1 pg/ml before operation and decreased to 90.2 +/- 44.5 pg/ml after operation. In the 3 patients with slightly elevated gastrin levels, the mean level before operation was 209.1 +/- 61.2 pg/ml. The gastrin level decreased to 116.4 +/- 62.0 pg/ml after operation. 3) Gastrin immunoreactivity was detected in 10 out of 14 tumors and its localization was at the periphery of tumor cells. From these results, we conclude that extragastric gastrin secretion from parathyroid tumors may be one of the cause of peptic ulcer in patients with primary hyperparathyroidism.

Authors+Show Affiliations

Department of Surgery, Yamagata University School of Medicine, Japan.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

English Abstract
Journal Article

Language

jpn

PubMed ID

2325610

Citation

Ouchi, K, et al. "[Plasma and Tumor Gastrin in Patients With Primary Hyperparathyroidism]." Nihon Geka Gakkai Zasshi, vol. 91, no. 2, 1990, pp. 262-5.
Ouchi K, Kameyama J, Hoshikawa T, et al. [Plasma and tumor gastrin in patients with primary hyperparathyroidism]. Nihon Geka Gakkai Zasshi. 1990;91(2):262-5.
Ouchi, K., Kameyama, J., Hoshikawa, T., Matsumoto, O., Ishiyama, S., Toyono, M., & Tsukamoto, M. (1990). [Plasma and tumor gastrin in patients with primary hyperparathyroidism]. Nihon Geka Gakkai Zasshi, 91(2), 262-5.
Ouchi K, et al. [Plasma and Tumor Gastrin in Patients With Primary Hyperparathyroidism]. Nihon Geka Gakkai Zasshi. 1990;91(2):262-5. PubMed PMID: 2325610.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - [Plasma and tumor gastrin in patients with primary hyperparathyroidism]. AU - Ouchi,K, AU - Kameyama,J, AU - Hoshikawa,T, AU - Matsumoto,O, AU - Ishiyama,S, AU - Toyono,M, AU - Tsukamoto,M, PY - 1990/2/1/pubmed PY - 1990/2/1/medline PY - 1990/2/1/entrez SP - 262 EP - 5 JF - Nihon Geka Gakkai zasshi JO - Nihon Geka Gakkai Zasshi VL - 91 IS - 2 N2 - It is well known that primary hyperparathyroidism is often associated with peptic ulcer. The purpose of this study is to confirm the relationship between the gastrin-levels before and after parathyroidectomy in fourteen patients with primary hyperparathyroidism, and to determine the localization of gastrin in the surgically resected parathyroid tumor. The results obtained were as follows: 1) Three patients had peptic ulcer (gastric ulcer and duodenal ulcer), the incidence being 21%. 2) The basal serum gastrin levels were 123.0% +/- 68.1 pg/ml before operation and decreased to 90.2 +/- 44.5 pg/ml after operation. In the 3 patients with slightly elevated gastrin levels, the mean level before operation was 209.1 +/- 61.2 pg/ml. The gastrin level decreased to 116.4 +/- 62.0 pg/ml after operation. 3) Gastrin immunoreactivity was detected in 10 out of 14 tumors and its localization was at the periphery of tumor cells. From these results, we conclude that extragastric gastrin secretion from parathyroid tumors may be one of the cause of peptic ulcer in patients with primary hyperparathyroidism. SN - 0301-4894 UR - https://www.unboundmedicine.com/medline/citation/2325610/[Plasma_and_tumor_gastrin_in_patients_with_primary_hyperparathyroidism]_ L2 - https://www.diseaseinfosearch.org/result/3590 DB - PRIME DP - Unbound Medicine ER -