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Effects of naringenin on allodynia and hyperalgesia in rats with chronic constriction injury-induced neuropathic pain.
Zhong Xi Yi Jie He Xue Bao. 2012 Dec; 10(12):1482-9.ZX

Abstract

OBJECTIVE

To study the analgesic effects of naringenin on chronic constriction injury (CCI) model of neuropathic pain.

METHODS

After inducing of neuropathic pain by CCI, treatment with 25 and 50 mg/kg of naringenin and 10 mg/kg of pregabalin was given. Rats were evaluated for behavioral tests using Hargreaves apparatus for thermal hyperalgesia, pin prick test for tactile mechanical hyperalgesia and cold water-induced allodynia on days 0, 3, 5, 7, 14 and 21. At the end of study, oxidative stress parameters were measured.

RESULTS

Naringenin showed ameliorating action against CCI-induced neuropathic pain in all the tested models. Also, naringenin attenuated the elevated levels of lipid peroxidation and nitric oxide, and restored the level of reduced glutathione.

CONCLUSION

The results of the present investigation suggest that naringenin exhibits analgesic effect in sciatic nerve injury model.

Links

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Authors+Show Affiliations

Kaulaskar S
Post-Graduate Research Department, Sinhgad College of Pharmacy, Pune 411041, Maharashtra, India.
Bhutada P
No affiliation info available
Rahigude A
No affiliation info available
Jain D
No affiliation info available
Harle U
No affiliation info available

MeSH

AnalgesicsAnimalsChronic PainConstrictionDisease Models, AnimalFlavanonesGlutathioneHyperalgesiaLipid PeroxidationMaleNeuralgiaNitric OxideOxidative StressRatsRats, Sprague-DawleySciatic Nerve

Pub Type(s)

Journal Article

Language

eng

PubMed ID

23257145

Citation

Kaulaskar, Shyam, et al. "Effects of Naringenin On Allodynia and Hyperalgesia in Rats With Chronic Constriction Injury-induced Neuropathic Pain." Zhong Xi Yi Jie He Xue Bao = Journal of Chinese Integrative Medicine, vol. 10, no. 12, 2012, pp. 1482-9.
Kaulaskar S, Bhutada P, Rahigude A, et al. Effects of naringenin on allodynia and hyperalgesia in rats with chronic constriction injury-induced neuropathic pain. Zhong Xi Yi Jie He Xue Bao. 2012;10(12):1482-9.
Kaulaskar, S., Bhutada, P., Rahigude, A., Jain, D., & Harle, U. (2012). Effects of naringenin on allodynia and hyperalgesia in rats with chronic constriction injury-induced neuropathic pain. Zhong Xi Yi Jie He Xue Bao = Journal of Chinese Integrative Medicine, 10(12), 1482-9. https://doi.org/10.3736/jcim20121223
Kaulaskar S, et al. Effects of Naringenin On Allodynia and Hyperalgesia in Rats With Chronic Constriction Injury-induced Neuropathic Pain. Zhong Xi Yi Jie He Xue Bao. 2012;10(12):1482-9. PubMed PMID: 23257145.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Effects of naringenin on allodynia and hyperalgesia in rats with chronic constriction injury-induced neuropathic pain. AU - Kaulaskar,Shyam, AU - Bhutada,Pravinkumar, AU - Rahigude,Anand, AU - Jain,Dilpesh, AU - Harle,Uday, PY - 2012/12/22/entrez PY - 2012/12/22/pubmed PY - 2013/12/18/medline SP - 1482 EP - 9 JF - Zhong xi yi jie he xue bao = Journal of Chinese integrative medicine JO - Zhong Xi Yi Jie He Xue Bao VL - 10 IS - 12 N2 - OBJECTIVE: To study the analgesic effects of naringenin on chronic constriction injury (CCI) model of neuropathic pain. METHODS: After inducing of neuropathic pain by CCI, treatment with 25 and 50 mg/kg of naringenin and 10 mg/kg of pregabalin was given. Rats were evaluated for behavioral tests using Hargreaves apparatus for thermal hyperalgesia, pin prick test for tactile mechanical hyperalgesia and cold water-induced allodynia on days 0, 3, 5, 7, 14 and 21. At the end of study, oxidative stress parameters were measured. RESULTS: Naringenin showed ameliorating action against CCI-induced neuropathic pain in all the tested models. Also, naringenin attenuated the elevated levels of lipid peroxidation and nitric oxide, and restored the level of reduced glutathione. CONCLUSION: The results of the present investigation suggest that naringenin exhibits analgesic effect in sciatic nerve injury model. SN - 1672-1977 UR - https://www.unboundmedicine.com/medline/citation/23257145/Effects_of_naringenin_on_allodynia_and_hyperalgesia_in_rats_with_chronic_constriction_injury_induced_neuropathic_pain_ L2 - https://www.lens.org/lens/search/patent/list?q=citation_id:23257145 DB - PRIME DP - Unbound Medicine ER -