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Comparative effectiveness of two doses versus three doses of hepatitis A vaccine in human immunodeficiency virus-infected and -uninfected men who have sex with men.
Hepatology. 2013 May; 57(5):1734-41.Hep

Abstract

The purpose of this prospective cohort study was to compare the serologic response between human immunodeficiency virus (HIV)-infected men who have sex with men (MSM) receiving two and three doses of hepatitis A virus (HAV) vaccine and HIV-uninfected MSM receiving two doses of HAV vaccine. Between June 2009 and December 2010, 582 MSM aged 18 to 40 years who were seronegative for HAV were enrolled in the study. HIV-infected MSM received either two doses of HAV vaccine (1,440 enzyme-linked immunosorbent assay units) (n = 140) with the second dose given at week 24 or three doses (n = 225) with the second and third dose given at weeks 4 and 24, respectively, while HIV-uninfected MSM (n = 217) received two doses. The primary endpoint was seroconversion at week 48. The geometric mean concentration (GMC) of anti-HAV antibody was determined at weeks 48 and 72. At week 48, the seroconversion rate was 75.7%, 77.8%, and 88.5% in intention-to-treat analysis for two-dose HIV-infected, three-dose HIV-infected, and two-dose HIV-uninfected MSM, respectively. The GMC of anti-HAV antibody at week 48 for three-dose HIV-infected MSM (2.29 ± 0.73 log10 mIU/mL) was significantly higher than that for two-dose HIV-infected MSM (1.94 ± 0.66; P < 0.01), but was lower than HIV-uninfected MSM (2.49 ± 0.42; P < 0.01). Multivariate analysis revealed higher CD4 counts (adjusted odds ratio [AOR] for per 50 cells/μL increase, 1.13; 95% confidence interval [CI], 1.05-1.21) and undetectable plasma HIV RNA load (AOR, 1.90; 95% CI, 1.10-3.28) before HAV vaccination were predictive of seroconversion in HIV-infected patients.

CONCLUSION

Serologic response rate to three and two doses of HAV vaccine was similar in HIV-infected MSM, which was lower than that in HIV-uninfected MSM receiving two doses. HAV vaccination in HIV-infected patients with a higher CD4 count and suppression of HIV replication increased the seroconversion rate.

Authors+Show Affiliations

Departments of Traumatology, National Taiwan University College of Medicine, Taipei, Taiwan.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Comparative Study
Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

23258666

Citation

Tseng, Yu-Tzu, et al. "Comparative Effectiveness of Two Doses Versus Three Doses of Hepatitis a Vaccine in Human Immunodeficiency Virus-infected and -uninfected Men Who Have Sex With Men." Hepatology (Baltimore, Md.), vol. 57, no. 5, 2013, pp. 1734-41.
Tseng YT, Chang SY, Liu WC, et al. Comparative effectiveness of two doses versus three doses of hepatitis A vaccine in human immunodeficiency virus-infected and -uninfected men who have sex with men. Hepatology. 2013;57(5):1734-41.
Tseng, Y. T., Chang, S. Y., Liu, W. C., Sun, H. Y., Wu, C. H., Wu, P. Y., Lu, C. L., Hung, C. C., & Chang, S. C. (2013). Comparative effectiveness of two doses versus three doses of hepatitis A vaccine in human immunodeficiency virus-infected and -uninfected men who have sex with men. Hepatology (Baltimore, Md.), 57(5), 1734-41. https://doi.org/10.1002/hep.26210
Tseng YT, et al. Comparative Effectiveness of Two Doses Versus Three Doses of Hepatitis a Vaccine in Human Immunodeficiency Virus-infected and -uninfected Men Who Have Sex With Men. Hepatology. 2013;57(5):1734-41. PubMed PMID: 23258666.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Comparative effectiveness of two doses versus three doses of hepatitis A vaccine in human immunodeficiency virus-infected and -uninfected men who have sex with men. AU - Tseng,Yu-Tzu, AU - Chang,Sui-Yuan, AU - Liu,Wen-Chun, AU - Sun,Hsin-Yun, AU - Wu,Cheng-Hsin, AU - Wu,Pei-Ying, AU - Lu,Ching-Lan, AU - Hung,Chien-Ching, AU - Chang,Shan-Chwen, Y1 - 2013/03/14/ PY - 2012/06/07/received PY - 2012/12/09/accepted PY - 2012/12/22/entrez PY - 2012/12/22/pubmed PY - 2013/7/6/medline SP - 1734 EP - 41 JF - Hepatology (Baltimore, Md.) JO - Hepatology VL - 57 IS - 5 N2 - UNLABELLED: The purpose of this prospective cohort study was to compare the serologic response between human immunodeficiency virus (HIV)-infected men who have sex with men (MSM) receiving two and three doses of hepatitis A virus (HAV) vaccine and HIV-uninfected MSM receiving two doses of HAV vaccine. Between June 2009 and December 2010, 582 MSM aged 18 to 40 years who were seronegative for HAV were enrolled in the study. HIV-infected MSM received either two doses of HAV vaccine (1,440 enzyme-linked immunosorbent assay units) (n = 140) with the second dose given at week 24 or three doses (n = 225) with the second and third dose given at weeks 4 and 24, respectively, while HIV-uninfected MSM (n = 217) received two doses. The primary endpoint was seroconversion at week 48. The geometric mean concentration (GMC) of anti-HAV antibody was determined at weeks 48 and 72. At week 48, the seroconversion rate was 75.7%, 77.8%, and 88.5% in intention-to-treat analysis for two-dose HIV-infected, three-dose HIV-infected, and two-dose HIV-uninfected MSM, respectively. The GMC of anti-HAV antibody at week 48 for three-dose HIV-infected MSM (2.29 ± 0.73 log10 mIU/mL) was significantly higher than that for two-dose HIV-infected MSM (1.94 ± 0.66; P < 0.01), but was lower than HIV-uninfected MSM (2.49 ± 0.42; P < 0.01). Multivariate analysis revealed higher CD4 counts (adjusted odds ratio [AOR] for per 50 cells/μL increase, 1.13; 95% confidence interval [CI], 1.05-1.21) and undetectable plasma HIV RNA load (AOR, 1.90; 95% CI, 1.10-3.28) before HAV vaccination were predictive of seroconversion in HIV-infected patients. CONCLUSION: Serologic response rate to three and two doses of HAV vaccine was similar in HIV-infected MSM, which was lower than that in HIV-uninfected MSM receiving two doses. HAV vaccination in HIV-infected patients with a higher CD4 count and suppression of HIV replication increased the seroconversion rate. SN - 1527-3350 UR - https://www.unboundmedicine.com/medline/citation/23258666/Comparative_effectiveness_of_two_doses_versus_three_doses_of_hepatitis_A_vaccine_in_human_immunodeficiency_virus_infected_and__uninfected_men_who_have_sex_with_men_ L2 - https://doi.org/10.1002/hep.26210 DB - PRIME DP - Unbound Medicine ER -