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Compression of coated drug beads for sustained release tablet of glipizide: formulation, and dissolution.
Pharm Dev Technol. 2014 Feb; 19(1):10-20.PD

Abstract

A promising glipizide formulation comprising compression of four-layer coated beads into tablets was prepared. The tablet offered the advantages of: a two-hour lag time before drug release, retaining sustained release characteristics and providing approximately zero-order drug release. Drug release was nearly independent of paddle speeds of 50 and 100 rpm releasing 80% over 14 h similar to the commercial glipizide osmotic pump tablet during dissolution testing while keeping the benefits of multiparticular dosage forms. The tablets contain beads with four layers: (1) the innermost layer consists of 2.5 g glipizide and 3.75 g solid ethylcellulose (Surelease®) coated onto 71.25 g of sugar beads; (2) next a hardening layer of 5 g of hypromellose; (3) the controlled release layer of 7.5 g of Surelease®:lactose at a solids ratio of 100:7 and (4) an outermost layer of 20 g of lactose:sodium starch glycolate (Explotab®) at a 2:1 ratio. Then, beads were compressed into tablets containing 11 mg of glipizide using 1500 lbs of compression pressure. The dissolution test similarity factor (f2) was above 50 for all test conditions for formulation F13 and Glucotrol® with a high of 69.9. The two Surelease® layers both aid controlling drug release, with the Surelease®-drug layer affecting drug release to a greater extent.

Authors+Show Affiliations

Industrial Department of Pharmacy, Hanoi University of Pharmacy , Hanoi , Vietnam.No affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

23259589

Citation

Nguyen, Chien, et al. "Compression of Coated Drug Beads for Sustained Release Tablet of Glipizide: Formulation, and Dissolution." Pharmaceutical Development and Technology, vol. 19, no. 1, 2014, pp. 10-20.
Nguyen C, Christensen JM, Ayres JW. Compression of coated drug beads for sustained release tablet of glipizide: formulation, and dissolution. Pharm Dev Technol. 2014;19(1):10-20.
Nguyen, C., Christensen, J. M., & Ayres, J. W. (2014). Compression of coated drug beads for sustained release tablet of glipizide: formulation, and dissolution. Pharmaceutical Development and Technology, 19(1), 10-20. https://doi.org/10.3109/10837450.2012.751402
Nguyen C, Christensen JM, Ayres JW. Compression of Coated Drug Beads for Sustained Release Tablet of Glipizide: Formulation, and Dissolution. Pharm Dev Technol. 2014;19(1):10-20. PubMed PMID: 23259589.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Compression of coated drug beads for sustained release tablet of glipizide: formulation, and dissolution. AU - Nguyen,Chien, AU - Christensen,J Mark, AU - Ayres,James W, Y1 - 2012/12/24/ PY - 2012/12/25/entrez PY - 2012/12/25/pubmed PY - 2014/7/16/medline SP - 10 EP - 20 JF - Pharmaceutical development and technology JO - Pharm Dev Technol VL - 19 IS - 1 N2 - A promising glipizide formulation comprising compression of four-layer coated beads into tablets was prepared. The tablet offered the advantages of: a two-hour lag time before drug release, retaining sustained release characteristics and providing approximately zero-order drug release. Drug release was nearly independent of paddle speeds of 50 and 100 rpm releasing 80% over 14 h similar to the commercial glipizide osmotic pump tablet during dissolution testing while keeping the benefits of multiparticular dosage forms. The tablets contain beads with four layers: (1) the innermost layer consists of 2.5 g glipizide and 3.75 g solid ethylcellulose (Surelease®) coated onto 71.25 g of sugar beads; (2) next a hardening layer of 5 g of hypromellose; (3) the controlled release layer of 7.5 g of Surelease®:lactose at a solids ratio of 100:7 and (4) an outermost layer of 20 g of lactose:sodium starch glycolate (Explotab®) at a 2:1 ratio. Then, beads were compressed into tablets containing 11 mg of glipizide using 1500 lbs of compression pressure. The dissolution test similarity factor (f2) was above 50 for all test conditions for formulation F13 and Glucotrol® with a high of 69.9. The two Surelease® layers both aid controlling drug release, with the Surelease®-drug layer affecting drug release to a greater extent. SN - 1097-9867 UR - https://www.unboundmedicine.com/medline/citation/23259589/Compression_of_coated_drug_beads_for_sustained_release_tablet_of_glipizide:_formulation_and_dissolution_ L2 - https://www.tandfonline.com/doi/full/10.3109/10837450.2012.751402 DB - PRIME DP - Unbound Medicine ER -