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Diffusion tensor imaging patterns differ in bulbar and limb onset amyotrophic lateral sclerosis.
Clin Neurol Neurosurg. 2013 Aug; 115(8):1281-7.CN

Abstract

BACKGROUND

Amyotrophic lateral sclerosis (ALS) is characterized by pronounced clinical heterogeneity in terms of onset and disease progression. Widespread changes in white matter fibres could be observed by diffusion tensor imaging (DTI), which detects alterations in the degree (diffusivity, ADC) and directedness (fractional anisotropy, FA) of proton movement. The aim of the current study was to determine whether different ALS onset types were reflected in different DTI brain patterns.

METHODS

Seventeen patients with a diagnosis of ALS (6 bulbar, 11 limb onset) and seventeen age-matched controls received 1.5T DTI, where FA and ADC were analyzed using statistical parametric mapping.

RESULTS

In ALS patients, an increased diffusivity in the white matter was found below the precentral gyrus and along the corticospinal tract (CST) right into the internal capsule. The FA was decreased in the posterior limb of internal capsule and in the subcortical white matter in the precentral gyrus. In bulbar onset increased diffusivity was found in the CST, whilst in limb onset, frontal subcortical areas displayed an increased diffusivity.

CONCLUSION

DTI changes can be regarded as prominent features in ALS. Herein we were able to demonstrate discriminating brain DTI patterns due to bulbar or limb onset.

Authors+Show Affiliations

Hans-Berger Department of Neurology, Jena University Hospital, Erlanger Allee 101, 07747 Jena, Germany. tino.prell@med.uni-jena.deNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

23266262

Citation

Prell, Tino, et al. "Diffusion Tensor Imaging Patterns Differ in Bulbar and Limb Onset Amyotrophic Lateral Sclerosis." Clinical Neurology and Neurosurgery, vol. 115, no. 8, 2013, pp. 1281-7.
Prell T, Peschel T, Hartung V, et al. Diffusion tensor imaging patterns differ in bulbar and limb onset amyotrophic lateral sclerosis. Clin Neurol Neurosurg. 2013;115(8):1281-7.
Prell, T., Peschel, T., Hartung, V., Kaufmann, J., Klauschies, R., Bodammer, N., Kollewe, K., Dengler, R., & Grosskreutz, J. (2013). Diffusion tensor imaging patterns differ in bulbar and limb onset amyotrophic lateral sclerosis. Clinical Neurology and Neurosurgery, 115(8), 1281-7. https://doi.org/10.1016/j.clineuro.2012.11.031
Prell T, et al. Diffusion Tensor Imaging Patterns Differ in Bulbar and Limb Onset Amyotrophic Lateral Sclerosis. Clin Neurol Neurosurg. 2013;115(8):1281-7. PubMed PMID: 23266262.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Diffusion tensor imaging patterns differ in bulbar and limb onset amyotrophic lateral sclerosis. AU - Prell,Tino, AU - Peschel,Thomas, AU - Hartung,Viktor, AU - Kaufmann,Joern, AU - Klauschies,Ribanna, AU - Bodammer,Nils, AU - Kollewe,Katja, AU - Dengler,Reinhard, AU - Grosskreutz,Julian, Y1 - 2012/12/23/ PY - 2012/07/31/received PY - 2012/11/27/revised PY - 2012/11/29/accepted PY - 2012/12/26/entrez PY - 2012/12/26/pubmed PY - 2014/2/22/medline KW - ADC KW - ALS KW - Amyotrophic lateral sclerosis KW - Biomarker KW - CST KW - Corticospinal tract KW - DTI KW - Diffusion tensor imaging KW - FA KW - Subtypes KW - amyotrophic lateral sclerosis KW - apparent diffusion coefficient KW - corticospinal tract KW - diffusion tensor imaging KW - fractional anisotropy SP - 1281 EP - 7 JF - Clinical neurology and neurosurgery JO - Clin Neurol Neurosurg VL - 115 IS - 8 N2 - BACKGROUND: Amyotrophic lateral sclerosis (ALS) is characterized by pronounced clinical heterogeneity in terms of onset and disease progression. Widespread changes in white matter fibres could be observed by diffusion tensor imaging (DTI), which detects alterations in the degree (diffusivity, ADC) and directedness (fractional anisotropy, FA) of proton movement. The aim of the current study was to determine whether different ALS onset types were reflected in different DTI brain patterns. METHODS: Seventeen patients with a diagnosis of ALS (6 bulbar, 11 limb onset) and seventeen age-matched controls received 1.5T DTI, where FA and ADC were analyzed using statistical parametric mapping. RESULTS: In ALS patients, an increased diffusivity in the white matter was found below the precentral gyrus and along the corticospinal tract (CST) right into the internal capsule. The FA was decreased in the posterior limb of internal capsule and in the subcortical white matter in the precentral gyrus. In bulbar onset increased diffusivity was found in the CST, whilst in limb onset, frontal subcortical areas displayed an increased diffusivity. CONCLUSION: DTI changes can be regarded as prominent features in ALS. Herein we were able to demonstrate discriminating brain DTI patterns due to bulbar or limb onset. SN - 1872-6968 UR - https://www.unboundmedicine.com/medline/citation/23266262/Diffusion_tensor_imaging_patterns_differ_in_bulbar_and_limb_onset_amyotrophic_lateral_sclerosis_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0303-8467(12)00609-9 DB - PRIME DP - Unbound Medicine ER -