Citation
Kim, Kil-Nam, et al. "Anti-inflammatory Effects of Trans-1,3-diphenyl-2,3-epoxypropane-1-one Mediated By Suppression of Inflammatory Mediators in LPS-stimulated RAW 264.7 Macrophages." Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association, vol. 53, 2013, pp. 371-5.
Kim KN, Ko YJ, Kang MC, et al. Anti-inflammatory effects of trans-1,3-diphenyl-2,3-epoxypropane-1-one mediated by suppression of inflammatory mediators in LPS-stimulated RAW 264.7 macrophages. Food Chem Toxicol. 2013;53:371-5.
Kim, K. N., Ko, Y. J., Kang, M. C., Yang, H. M., Roh, S. W., Oda, T., Jeon, Y. J., Jung, W. K., Heo, S. J., Yoon, W. J., & Kim, D. (2013). Anti-inflammatory effects of trans-1,3-diphenyl-2,3-epoxypropane-1-one mediated by suppression of inflammatory mediators in LPS-stimulated RAW 264.7 macrophages. Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association, 53, 371-5. https://doi.org/10.1016/j.fct.2012.12.021
Kim KN, et al. Anti-inflammatory Effects of Trans-1,3-diphenyl-2,3-epoxypropane-1-one Mediated By Suppression of Inflammatory Mediators in LPS-stimulated RAW 264.7 Macrophages. Food Chem Toxicol. 2013;53:371-5. PubMed PMID: 23266270.
TY - JOUR
T1 - Anti-inflammatory effects of trans-1,3-diphenyl-2,3-epoxypropane-1-one mediated by suppression of inflammatory mediators in LPS-stimulated RAW 264.7 macrophages.
AU - Kim,Kil-Nam,
AU - Ko,Yeong-Jong,
AU - Kang,Min-Cheol,
AU - Yang,Hye-Mi,
AU - Roh,Seong Woon,
AU - Oda,Tatsuya,
AU - Jeon,You-Jin,
AU - Jung,Won-Kyo,
AU - Heo,Soo-Jin,
AU - Yoon,Weon-Jong,
AU - Kim,Daekyung,
Y1 - 2012/12/21/
PY - 2012/07/27/received
PY - 2012/12/12/revised
PY - 2012/12/14/accepted
PY - 2012/12/26/entrez
PY - 2012/12/26/pubmed
PY - 2013/8/27/medline
SP - 371
EP - 5
JF - Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association
JO - Food Chem Toxicol
VL - 53
N2 - To assess the potential therapeutic properties of trans-1,3-diphenyl-2,3-epoxypropane-1-one (DPEP), its anti-inflammatory effects were investigated in lipopolysaccharide (LPS)-stimulated mouse macrophage (RAW 264.7) cells. DPEP induced dose-dependent reduction of the protein levels of inducible nitric oxide synthase (iNOS) and cyclooxygenase-2 (COX-2) and concomitant reduction in the production of NO and prostaglandin E(2) (PGE(2)). Additionally, DPEP suppressed the production of inflammatory cytokines, including tumor necrosis factor-α (TNF-α), interleukin (IL)-1β, and IL-6. We investigated the mechanism by which DPEP inhibits NO and PGE(2) by examining the level of nuclear factor-κB (NF-κB) activation within the mitogen-activated protein kinase (MAPK) pathway, which is an inflammation-induced signaling pathway in RAW 264.7 cells. DPEP inhibited LPS-induced phosphorylation of ERK, JNK, and p38. Furthermore, DPEP inhibited the LPS-induced phosphorylation of inhibitor κB (IκB)-α and NF-κB p50. Taken together, the results of this study demonstrate that DPEP inhibits LPS-stimulated inflammation by blocking the NF-κB and MAPK pathways in macrophages.
SN - 1873-6351
UR - https://www.unboundmedicine.com/medline/citation/23266270/Anti_inflammatory_effects_of_trans_13_diphenyl_23_epoxypropane_1_one_mediated_by_suppression_of_inflammatory_mediators_in_LPS_stimulated_RAW_264_7_macrophages_
DB - PRIME
DP - Unbound Medicine
ER -
