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Sibiricasaponins A-E, five new triterpenoid saponins from the aerial parts of Polygala sibirica L.
Fitoterapia. 2013 Jan; 84:295-301.F

Abstract

Five new triterpenoid saponins, named as sibiricasaponins A-E (1-5), were isolated and identified from the aerial parts of Polygala sibirica L., together with nine known triterpenoid saponins (6-14). The chemical structures of the five new triterpenoid saponins (1-5) were elucidated as 3β,19α-dihydroxyurso-12-ene-23,28-dioic acid 3-O-β-d-glucuronopyranoside (1), pomolic acid 3-O-(3-O-sulfo)-α-l-arabinopyranoside (2), pomolic acid 3-O-(4-O-sulfo)-β-d-xylopyranoside (3), pomolic acid 3-O-(2-O-acetyl-3-O-sulfo)-α-l-arabinopyranoside (4), and 3-O-β-d-glucopyranosyl medicagenic acid 28-O-β-d-galactopyranosyl (1→4)-β-d-xylopyranosyl (1→4)-α-l-rhamnopyranosyl (1→2)-(4-O-acetyl)-[β-d-apiofuranosyl (1→3)]-β-d-fucopyranosyl ester (5), respectively, on the basis of spectroscopic data and physicochemical evidences. These isolated compounds (1-14) were evaluated for their anti-ischemic effects on oxygen/glucose deprivation (OGD) model in vitro, and only compound 7 showed a weak anti-ischemia effect, with EC(50) value of 46.7μM.

Authors+Show Affiliations

State Key Laboratory of Natural and Biomimetic Drugs, School of Pharmaceutical Sciences, Peking University, Beijing 100191, China.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

23266727

Citation

Song, Yue-Lin, et al. "Sibiricasaponins A-E, Five New Triterpenoid Saponins From the Aerial Parts of Polygala Sibirica L." Fitoterapia, vol. 84, 2013, pp. 295-301.
Song YL, Zeng KW, Shi TX, et al. Sibiricasaponins A-E, five new triterpenoid saponins from the aerial parts of Polygala sibirica L. Fitoterapia. 2013;84:295-301.
Song, Y. L., Zeng, K. W., Shi, T. X., Jiang, Y., & Tu, P. F. (2013). Sibiricasaponins A-E, five new triterpenoid saponins from the aerial parts of Polygala sibirica L. Fitoterapia, 84, 295-301. https://doi.org/10.1016/j.fitote.2012.12.017
Song YL, et al. Sibiricasaponins A-E, Five New Triterpenoid Saponins From the Aerial Parts of Polygala Sibirica L. Fitoterapia. 2013;84:295-301. PubMed PMID: 23266727.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Sibiricasaponins A-E, five new triterpenoid saponins from the aerial parts of Polygala sibirica L. AU - Song,Yue-Lin, AU - Zeng,Ke-Wu, AU - Shi,Tian-Xing, AU - Jiang,Yong, AU - Tu,Peng-Fei, Y1 - 2012/12/22/ PY - 2012/09/11/received PY - 2012/12/13/revised PY - 2012/12/13/accepted PY - 2012/12/26/entrez PY - 2012/12/26/pubmed PY - 2013/7/28/medline SP - 295 EP - 301 JF - Fitoterapia JO - Fitoterapia VL - 84 N2 - Five new triterpenoid saponins, named as sibiricasaponins A-E (1-5), were isolated and identified from the aerial parts of Polygala sibirica L., together with nine known triterpenoid saponins (6-14). The chemical structures of the five new triterpenoid saponins (1-5) were elucidated as 3β,19α-dihydroxyurso-12-ene-23,28-dioic acid 3-O-β-d-glucuronopyranoside (1), pomolic acid 3-O-(3-O-sulfo)-α-l-arabinopyranoside (2), pomolic acid 3-O-(4-O-sulfo)-β-d-xylopyranoside (3), pomolic acid 3-O-(2-O-acetyl-3-O-sulfo)-α-l-arabinopyranoside (4), and 3-O-β-d-glucopyranosyl medicagenic acid 28-O-β-d-galactopyranosyl (1→4)-β-d-xylopyranosyl (1→4)-α-l-rhamnopyranosyl (1→2)-(4-O-acetyl)-[β-d-apiofuranosyl (1→3)]-β-d-fucopyranosyl ester (5), respectively, on the basis of spectroscopic data and physicochemical evidences. These isolated compounds (1-14) were evaluated for their anti-ischemic effects on oxygen/glucose deprivation (OGD) model in vitro, and only compound 7 showed a weak anti-ischemia effect, with EC(50) value of 46.7μM. SN - 1873-6971 UR - https://www.unboundmedicine.com/medline/citation/23266727/Sibiricasaponins_A_E_five_new_triterpenoid_saponins_from_the_aerial_parts_of_Polygala_sibirica_L_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0367-326X(12)00344-9 DB - PRIME DP - Unbound Medicine ER -