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Role of leptin and adiponectin in insulin resistance.

Abstract

Adipose tissue is a major source of energy for the human body. It is also a source of major adipocytokines adiponectin and leptin. Insulin resistance is a condition in which insulin action is impaired in adipose tissue and is more strongly linked to intra-abdominal fat than to fat in other depots. The expression of adiponectin decreases with increase in the adiposity. Adiponectin mediates insulin-sensitizing effect through binding to its receptors AdipoR1 and AdipoR2, leading to activation of adenosine monophosphate dependent kinase (AMPK), PPAR-α, and presumably other yet-unknown signalling pathways. Weight loss significantly elevates plasma adiponectin levels. Reduction of adiponectin has been associated with insulin resistance, dyslipidemia, and atherosclerosis in humans. The other major adipokine is leptin. Leptin levels increase in obesity and subcutaneous fat has been a major determinant of circulating leptin levels. The leptin signal is transmitted by the Janus kinase, signal transducer and activator of transcription ((JAK-STAT) pathway. The net action of leptin is to inhibit appetite, stimulate thermogenesis, enhance fatty acid oxidation, decrease glucose, and reduce body weight and fat.

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  • Authors+Show Affiliations

    ,

    Department of Biochemistry, Lady Hardinge Medical College and Associated Hospitals, New Delhi, India. dramita.md@gmail.com

    , ,

    Source

    MeSH

    Adiponectin
    Adipose Tissue
    Humans
    Insulin Resistance
    Leptin

    Pub Type(s)

    Journal Article
    Review

    Language

    eng

    PubMed ID

    23266767

    Citation

    Yadav, Amita, et al. "Role of Leptin and Adiponectin in Insulin Resistance." Clinica Chimica Acta; International Journal of Clinical Chemistry, vol. 417, 2013, pp. 80-4.
    Yadav A, Kataria MA, Saini V, et al. Role of leptin and adiponectin in insulin resistance. Clin Chim Acta. 2013;417:80-4.
    Yadav, A., Kataria, M. A., Saini, V., & Yadav, A. (2013). Role of leptin and adiponectin in insulin resistance. Clinica Chimica Acta; International Journal of Clinical Chemistry, 417, pp. 80-4. doi:10.1016/j.cca.2012.12.007.
    Yadav A, et al. Role of Leptin and Adiponectin in Insulin Resistance. Clin Chim Acta. 2013 Feb 18;417:80-4. PubMed PMID: 23266767.
    * Article titles in AMA citation format should be in sentence-case
    TY - JOUR T1 - Role of leptin and adiponectin in insulin resistance. AU - Yadav,Amita, AU - Kataria,Megha A, AU - Saini,Vandana, AU - Yadav,Anil, Y1 - 2012/12/22/ PY - 2012/07/24/received PY - 2012/11/30/revised PY - 2012/12/02/accepted PY - 2012/12/26/entrez PY - 2012/12/26/pubmed PY - 2013/8/28/medline SP - 80 EP - 4 JF - Clinica chimica acta; international journal of clinical chemistry JO - Clin. Chim. Acta VL - 417 N2 - Adipose tissue is a major source of energy for the human body. It is also a source of major adipocytokines adiponectin and leptin. Insulin resistance is a condition in which insulin action is impaired in adipose tissue and is more strongly linked to intra-abdominal fat than to fat in other depots. The expression of adiponectin decreases with increase in the adiposity. Adiponectin mediates insulin-sensitizing effect through binding to its receptors AdipoR1 and AdipoR2, leading to activation of adenosine monophosphate dependent kinase (AMPK), PPAR-α, and presumably other yet-unknown signalling pathways. Weight loss significantly elevates plasma adiponectin levels. Reduction of adiponectin has been associated with insulin resistance, dyslipidemia, and atherosclerosis in humans. The other major adipokine is leptin. Leptin levels increase in obesity and subcutaneous fat has been a major determinant of circulating leptin levels. The leptin signal is transmitted by the Janus kinase, signal transducer and activator of transcription ((JAK-STAT) pathway. The net action of leptin is to inhibit appetite, stimulate thermogenesis, enhance fatty acid oxidation, decrease glucose, and reduce body weight and fat. SN - 1873-3492 UR - https://www.unboundmedicine.com/medline/citation/23266767/Role_of_leptin_and_adiponectin_in_insulin_resistance_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0009-8981(12)00577-3 DB - PRIME DP - Unbound Medicine ER -