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Genipin crosslinked ethyl cellulose-chitosan complex microspheres for anti-tuberculosis delivery.
Colloids Surf B Biointerfaces. 2013 Mar 01; 103:530-7.CS

Abstract

Genipin-crosslinked complex microspheres made of the combination of two polymers, ethyl cellulose and chitosan, were prepared by spray drying method. Rifabutin, an anti-tuberculosis agent was used as a model drug. Effects of various specifications of ethyl cellulose and chitosan, different drug/polymers ratios and crosslinking effect of genipin on complex microspheres and drug release characteristics were compared to obtain optimized manufacturing parameters. The complex microspheres showed a significant different shape as compared to chitosan microspheres. Biphasic release features were observed in the in vitro and in vivo release study, consisting of an initial quick release phase and an extended sustained release phase. Furthermore, pulmonary drug concentrations of rats after administering the complex microspheres were maintained on a therapeutic level for at least 24 days.

Authors+Show Affiliations

Institute of Medicinal Plant Development, Chinese Academy of Medical Sciences, Key Laboratory of Bioactive Substances and Resources Utilization of Chinese Herbal Medicine, Ministry of Education, Beijing 100193, PR China.No affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

23266829

Citation

Feng, Hanzhou, et al. "Genipin Crosslinked Ethyl Cellulose-chitosan Complex Microspheres for Anti-tuberculosis Delivery." Colloids and Surfaces. B, Biointerfaces, vol. 103, 2013, pp. 530-7.
Feng H, Zhang L, Zhu C. Genipin crosslinked ethyl cellulose-chitosan complex microspheres for anti-tuberculosis delivery. Colloids Surf B Biointerfaces. 2013;103:530-7.
Feng, H., Zhang, L., & Zhu, C. (2013). Genipin crosslinked ethyl cellulose-chitosan complex microspheres for anti-tuberculosis delivery. Colloids and Surfaces. B, Biointerfaces, 103, 530-7. https://doi.org/10.1016/j.colsurfb.2012.11.007
Feng H, Zhang L, Zhu C. Genipin Crosslinked Ethyl Cellulose-chitosan Complex Microspheres for Anti-tuberculosis Delivery. Colloids Surf B Biointerfaces. 2013 Mar 1;103:530-7. PubMed PMID: 23266829.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Genipin crosslinked ethyl cellulose-chitosan complex microspheres for anti-tuberculosis delivery. AU - Feng,Hanzhou, AU - Zhang,Limei, AU - Zhu,Chunyan, Y1 - 2012/11/22/ PY - 2012/08/12/received PY - 2012/11/06/revised PY - 2012/11/10/accepted PY - 2012/12/26/entrez PY - 2012/12/26/pubmed PY - 2013/8/2/medline SP - 530 EP - 7 JF - Colloids and surfaces. B, Biointerfaces JO - Colloids Surf B Biointerfaces VL - 103 N2 - Genipin-crosslinked complex microspheres made of the combination of two polymers, ethyl cellulose and chitosan, were prepared by spray drying method. Rifabutin, an anti-tuberculosis agent was used as a model drug. Effects of various specifications of ethyl cellulose and chitosan, different drug/polymers ratios and crosslinking effect of genipin on complex microspheres and drug release characteristics were compared to obtain optimized manufacturing parameters. The complex microspheres showed a significant different shape as compared to chitosan microspheres. Biphasic release features were observed in the in vitro and in vivo release study, consisting of an initial quick release phase and an extended sustained release phase. Furthermore, pulmonary drug concentrations of rats after administering the complex microspheres were maintained on a therapeutic level for at least 24 days. SN - 1873-4367 UR - https://www.unboundmedicine.com/medline/citation/23266829/Genipin_crosslinked_ethyl_cellulose_chitosan_complex_microspheres_for_anti_tuberculosis_delivery_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0927-7765(12)00642-X DB - PRIME DP - Unbound Medicine ER -