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Neuraminidase inhibitor susceptibility testing of influenza type B viruses in China during 2010 and 2011 identifies viruses with reduced susceptibility to oseltamivir and zanamivir.
Antiviral Res. 2013 Mar; 97(3):240-4.AR

Abstract

Influenza type B viruses are responsible for substantial morbidity and mortality in humans. Antiviral drugs are an important supplement to vaccination for reducing the public health impact of influenza virus infections. Influenza B viruses are not sensitive to M2 inhibitors which limit the current therapeutic options to two neuraminidase inhibitors (NAIs), oseltamivir and zanamivir, which are licensed in many countries. Drug resistance is a public health concern which has necessitated monitoring of influenza virus drug susceptibilities through active global surveillance. Here, we report the results of drug susceptibility surveillance of influenza type B viruses (n=680) collected in mainland China during two calendar years, 2010 and 2011, assessed using functional neuraminidase (NA) inhibition (NI) assays. Four influenza B viruses exhibited reduced susceptibilities to oseltamivir, but not zanamivir, and shared the amino acid substitution I221T (ATC→ACC), at this conserved residue in the NA active site (I222T in N2 numbering). Additionally, a single virus with reduced susceptibility to both oseltamivir and zanamivir was identified and contained an amino acid substitution D197N (GAC→AAC) at another conserved residue in the NA active site (D198N in N2 numbering). This report underlies the importance of continued influenza antiviral susceptibility surveillance globally, even in countries where the use of NAIs has been low or non-existing.

Authors+Show Affiliations

Chinese National Influenza Center, National Institute for Viral Disease Control and Prevention, Chinese Centre for Disease Control and Prevention, Beijing, China.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

23267831

Citation

Wang, Dayan, et al. "Neuraminidase Inhibitor Susceptibility Testing of Influenza Type B Viruses in China During 2010 and 2011 Identifies Viruses With Reduced Susceptibility to Oseltamivir and Zanamivir." Antiviral Research, vol. 97, no. 3, 2013, pp. 240-4.
Wang D, Sleeman K, Huang W, et al. Neuraminidase inhibitor susceptibility testing of influenza type B viruses in China during 2010 and 2011 identifies viruses with reduced susceptibility to oseltamivir and zanamivir. Antiviral Res. 2013;97(3):240-4.
Wang, D., Sleeman, K., Huang, W., Nguyen, H. T., Levine, M., Cheng, Y., Li, X., Tan, M., Xing, X., Xu, X., Klimov, A. I., Gubareva, L. V., & Shu, Y. (2013). Neuraminidase inhibitor susceptibility testing of influenza type B viruses in China during 2010 and 2011 identifies viruses with reduced susceptibility to oseltamivir and zanamivir. Antiviral Research, 97(3), 240-4. https://doi.org/10.1016/j.antiviral.2012.12.013
Wang D, et al. Neuraminidase Inhibitor Susceptibility Testing of Influenza Type B Viruses in China During 2010 and 2011 Identifies Viruses With Reduced Susceptibility to Oseltamivir and Zanamivir. Antiviral Res. 2013;97(3):240-4. PubMed PMID: 23267831.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Neuraminidase inhibitor susceptibility testing of influenza type B viruses in China during 2010 and 2011 identifies viruses with reduced susceptibility to oseltamivir and zanamivir. AU - Wang,Dayan, AU - Sleeman,Katrina, AU - Huang,Weijuan, AU - Nguyen,Ha T, AU - Levine,Marnie, AU - Cheng,Yanhui, AU - Li,Xiyan, AU - Tan,Minju, AU - Xing,Xiaohui, AU - Xu,Xiyan, AU - Klimov,Alexander I, AU - Gubareva,Larisa V, AU - Shu,Yuelong, Y1 - 2012/12/23/ PY - 2012/08/17/received PY - 2012/12/09/revised PY - 2012/12/12/accepted PY - 2012/12/27/entrez PY - 2012/12/27/pubmed PY - 2013/9/13/medline SP - 240 EP - 4 JF - Antiviral research JO - Antiviral Res VL - 97 IS - 3 N2 - Influenza type B viruses are responsible for substantial morbidity and mortality in humans. Antiviral drugs are an important supplement to vaccination for reducing the public health impact of influenza virus infections. Influenza B viruses are not sensitive to M2 inhibitors which limit the current therapeutic options to two neuraminidase inhibitors (NAIs), oseltamivir and zanamivir, which are licensed in many countries. Drug resistance is a public health concern which has necessitated monitoring of influenza virus drug susceptibilities through active global surveillance. Here, we report the results of drug susceptibility surveillance of influenza type B viruses (n=680) collected in mainland China during two calendar years, 2010 and 2011, assessed using functional neuraminidase (NA) inhibition (NI) assays. Four influenza B viruses exhibited reduced susceptibilities to oseltamivir, but not zanamivir, and shared the amino acid substitution I221T (ATC→ACC), at this conserved residue in the NA active site (I222T in N2 numbering). Additionally, a single virus with reduced susceptibility to both oseltamivir and zanamivir was identified and contained an amino acid substitution D197N (GAC→AAC) at another conserved residue in the NA active site (D198N in N2 numbering). This report underlies the importance of continued influenza antiviral susceptibility surveillance globally, even in countries where the use of NAIs has been low or non-existing. SN - 1872-9096 UR - https://www.unboundmedicine.com/medline/citation/23267831/Neuraminidase_inhibitor_susceptibility_testing_of_influenza_type_B_viruses_in_China_during_2010_and_2011_identifies_viruses_with_reduced_susceptibility_to_oseltamivir_and_zanamivir_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0166-3542(12)00293-8 DB - PRIME DP - Unbound Medicine ER -