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Nucleophilic addition of benzimidazoles to alkynyl bromides/palladium-catalyzed intramolecular C-H vinylation: synthesis of benzo[4,5]imidazo[2,1-a]isoquinolines.
J Org Chem. 2013 Feb 01; 78(3):1242-8.JO

Abstract

An efficient "one-pot" route for the synthesis of benzo[4,5]imidazo[2,1-a] isoquinolines has been developed via nucleophilic addition of 2-aryl benzimidazoles to alkynyl bromides and subsequent palladium-catalyzed intramolecular C-H vinylation.

Authors+Show Affiliations

Department of Chemistry and Chemical Engineering, College of Science, Northeast Forestry University, Harbin, 150040, P. R. China.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

23272698

Citation

Peng, Jinsong, et al. "Nucleophilic Addition of Benzimidazoles to Alkynyl Bromides/palladium-catalyzed Intramolecular C-H Vinylation: Synthesis of Benzo[4,5]imidazo[2,1-a]isoquinolines." The Journal of Organic Chemistry, vol. 78, no. 3, 2013, pp. 1242-8.
Peng J, Shang G, Chen C, et al. Nucleophilic addition of benzimidazoles to alkynyl bromides/palladium-catalyzed intramolecular C-H vinylation: synthesis of benzo[4,5]imidazo[2,1-a]isoquinolines. J Org Chem. 2013;78(3):1242-8.
Peng, J., Shang, G., Chen, C., Miao, Z., & Li, B. (2013). Nucleophilic addition of benzimidazoles to alkynyl bromides/palladium-catalyzed intramolecular C-H vinylation: synthesis of benzo[4,5]imidazo[2,1-a]isoquinolines. The Journal of Organic Chemistry, 78(3), 1242-8. https://doi.org/10.1021/jo302471z
Peng J, et al. Nucleophilic Addition of Benzimidazoles to Alkynyl Bromides/palladium-catalyzed Intramolecular C-H Vinylation: Synthesis of Benzo[4,5]imidazo[2,1-a]isoquinolines. J Org Chem. 2013 Feb 1;78(3):1242-8. PubMed PMID: 23272698.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Nucleophilic addition of benzimidazoles to alkynyl bromides/palladium-catalyzed intramolecular C-H vinylation: synthesis of benzo[4,5]imidazo[2,1-a]isoquinolines. AU - Peng,Jinsong, AU - Shang,Guoning, AU - Chen,Chunxia, AU - Miao,Zhongshuo, AU - Li,Bin, Y1 - 2013/01/07/ PY - 2013/1/1/entrez PY - 2013/1/1/pubmed PY - 2013/8/10/medline SP - 1242 EP - 8 JF - The Journal of organic chemistry JO - J Org Chem VL - 78 IS - 3 N2 - An efficient "one-pot" route for the synthesis of benzo[4,5]imidazo[2,1-a] isoquinolines has been developed via nucleophilic addition of 2-aryl benzimidazoles to alkynyl bromides and subsequent palladium-catalyzed intramolecular C-H vinylation. SN - 1520-6904 UR - https://www.unboundmedicine.com/medline/citation/23272698/Nucleophilic_addition_of_benzimidazoles_to_alkynyl_bromides/palladium_catalyzed_intramolecular_C_H_vinylation:_synthesis_of_benzo[45]imidazo[21_a]isoquinolines_ L2 - https://doi.org/10.1021/jo302471z DB - PRIME DP - Unbound Medicine ER -