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Alcohol drinking and endometrial cancer risk in the European Prospective Investigation into Cancer and Nutrition (EPIC) study.
Ann Epidemiol 2013; 23(2):93-8AE

Abstract

PURPOSE

Alcohol intake may adversely affect the concentrations of endogenous sex hormones, and thus increase the risk of endometrial cancer. However, epidemiologic studies have provided conflicting results. Therefore, we investigated the association between alcohol intake and endometrial cancer risk a large, multicenter, prospective study.

METHODS

From 1992 through 2010, 301,051 women in the European Prospective Investigation into Cancer and Nutrition (EPIC) cohort were followed for incident endometrial cancer (n = 1382). Baseline alcohol consumption was assessed by country-specific, validated dietary questionnaires. Information on past alcohol consumption was collected by lifestyle questionnaires. Hazard ratios (HRs) and 95% confidence intervals (CIs) were estimated from Cox proportional hazard models.

RESULTS

The multivariable HRs (and 95% CIs) compared with light drinkers (0.1-6 g/d) were 1.03 (0.88-1.20) for 0 g of alcohol per day at baseline, 1.01 (0.86-1.17) for 6.1-12 g/d, 1.03 (0.87-1.22) for 12.1-24 g/d, 1.07 (0.87-1.38) for 24.1-36 g/d, and 0.85 (0.61-1.18) for more than 36 g/d (p(trend) = 0.77). No association was observed among former drinkers (OR, 1.28; 95% CI, 0.98-1.68 compared with light drinkers). Null associations were also found between alcohol consumption at age 20 years, lifetime pattern of alcohol drinking, and baseline alcohol intake from specific alcoholic beverages and endometrial cancer risk.

CONCLUSIONS

Our findings suggest no association between alcohol intake and endometrial cancer risk.

Authors+Show Affiliations

International Agency for Research on Cancer (IARC-WHO), Lyon, France. nep.iarc.frNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

23273691

Citation

Fedirko, Veronika, et al. "Alcohol Drinking and Endometrial Cancer Risk in the European Prospective Investigation Into Cancer and Nutrition (EPIC) Study." Annals of Epidemiology, vol. 23, no. 2, 2013, pp. 93-8.
Fedirko V, Jenab M, Rinaldi S, et al. Alcohol drinking and endometrial cancer risk in the European Prospective Investigation into Cancer and Nutrition (EPIC) study. Ann Epidemiol. 2013;23(2):93-8.
Fedirko, V., Jenab, M., Rinaldi, S., Biessy, C., Allen, N. E., Dossus, L., ... Romieu, I. (2013). Alcohol drinking and endometrial cancer risk in the European Prospective Investigation into Cancer and Nutrition (EPIC) study. Annals of Epidemiology, 23(2), pp. 93-8. doi:10.1016/j.annepidem.2012.11.009.
Fedirko V, et al. Alcohol Drinking and Endometrial Cancer Risk in the European Prospective Investigation Into Cancer and Nutrition (EPIC) Study. Ann Epidemiol. 2013;23(2):93-8. PubMed PMID: 23273691.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Alcohol drinking and endometrial cancer risk in the European Prospective Investigation into Cancer and Nutrition (EPIC) study. AU - Fedirko,Veronika, AU - Jenab,Mazda, AU - Rinaldi,Sabina, AU - Biessy,Carine, AU - Allen,Naomi E, AU - Dossus,Laure, AU - Onland-Moret,N Charlotte, AU - Schütze,Madlen, AU - Tjønneland,Anne, AU - Hansen,Louise, AU - Overvad,Kim, AU - Clavel-Chapelon,Françoise, AU - Chabbert-Buffet,Nathalie, AU - Kaaks,Rudolf, AU - Lukanova,Annekatrin, AU - Bergmann,Manuela M, AU - Boeing,Heiner, AU - Trichopoulou,Antonia, AU - Oustoglou,Erifili, AU - Barbitsioti,Antonia, AU - Saieva,Calogero, AU - Tagliabue,Giovanna, AU - Galasso,Rocco, AU - Tumino,Rosario, AU - Sacerdote,Carlotta, AU - Peeters,Petra H, AU - Bueno-de-Mesquita,H Bas, AU - Weiderpass,Elisabete, AU - Gram,Inger Torhild, AU - Sanchez,Soledad, AU - Duell,Eric J, AU - Molina-Montes,Esther, AU - Arriola,Larraitz, AU - Chirlaque,Maria-Dolores, AU - Ardanaz,Eva, AU - Manjer,Jonas, AU - Lundin,Eva, AU - Idahl,Annika, AU - Khaw,Kay-Tee, AU - Romaguera-Bosch,Dora, AU - Wark,Petra A, AU - Norat,Teresa, AU - Romieu,Isabelle, Y1 - 2012/12/25/ PY - 2012/08/25/received PY - 2012/11/16/revised PY - 2012/11/25/accepted PY - 2013/1/1/entrez PY - 2013/1/1/pubmed PY - 2013/4/25/medline SP - 93 EP - 8 JF - Annals of epidemiology JO - Ann Epidemiol VL - 23 IS - 2 N2 - PURPOSE: Alcohol intake may adversely affect the concentrations of endogenous sex hormones, and thus increase the risk of endometrial cancer. However, epidemiologic studies have provided conflicting results. Therefore, we investigated the association between alcohol intake and endometrial cancer risk a large, multicenter, prospective study. METHODS: From 1992 through 2010, 301,051 women in the European Prospective Investigation into Cancer and Nutrition (EPIC) cohort were followed for incident endometrial cancer (n = 1382). Baseline alcohol consumption was assessed by country-specific, validated dietary questionnaires. Information on past alcohol consumption was collected by lifestyle questionnaires. Hazard ratios (HRs) and 95% confidence intervals (CIs) were estimated from Cox proportional hazard models. RESULTS: The multivariable HRs (and 95% CIs) compared with light drinkers (0.1-6 g/d) were 1.03 (0.88-1.20) for 0 g of alcohol per day at baseline, 1.01 (0.86-1.17) for 6.1-12 g/d, 1.03 (0.87-1.22) for 12.1-24 g/d, 1.07 (0.87-1.38) for 24.1-36 g/d, and 0.85 (0.61-1.18) for more than 36 g/d (p(trend) = 0.77). No association was observed among former drinkers (OR, 1.28; 95% CI, 0.98-1.68 compared with light drinkers). Null associations were also found between alcohol consumption at age 20 years, lifetime pattern of alcohol drinking, and baseline alcohol intake from specific alcoholic beverages and endometrial cancer risk. CONCLUSIONS: Our findings suggest no association between alcohol intake and endometrial cancer risk. SN - 1873-2585 UR - https://www.unboundmedicine.com/medline/citation/23273691/Alcohol_drinking_and_endometrial_cancer_risk_in_the_European_Prospective_Investigation_into_Cancer_and_Nutrition__EPIC__study_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S1047-2797(12)00450-4 DB - PRIME DP - Unbound Medicine ER -