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Evaluation of the genotoxic and cytotoxic effects of glyphosate-based herbicides in the ten spotted live-bearer fish Cnesterodon decemmaculatus (Jenyns, 1842).
Ecotoxicol Environ Saf. 2013 Mar; 89:166-73.EE

Abstract

Mortality, genotoxicity, and cytotoxicity of the 48% glyphosate-based formulations Panzer and Credit(®) were evaluated on Cnesterodon decemmaculatus (Jenyns, 1842) (Pisces, Poeciliidae) under laboratory conditions. Induction of micronuclei (MN) and alterations in the erythrocytes:erythroblasts ratio were employed as end points for genotoxicity and cytotoxicity, respectively. For Panzer(®), mean values of 16.70 and 15.68 mg/L were determined for LC(50) at 24 and 96 h, respectively, and these concentrations reached mean values of 98.50 and 91.73 mg/L for Credit(®). LC(50) values decreased as a negative linear function of Panzer(®) exposure time within the 0-96 h period, but not for Credit(®). LC(50) values indicated that the fish were more sensitive to Panzer(®) than to Credit(®). Both 3.9 and 7.8 mg/L of Panzer(®) increased MN frequency at 48 and 96 h of treatment. When fish were exposed to Credit(®), an increased frequency of MN over control values was found after 96 h for all concentrations assayed, but not after 48 h. No cellular cytotoxicity was found after Panzer(®) and Credit(®) treatment, regardless of both the concentration and the sampling time. Furthermore, our results demonstrated that Panzer(®) and Credit(®) should be considered as glyphosate-based commercial formulations with genotoxic but not cytotoxic effect properties.

Authors+Show Affiliations

Cátedra de Citología, Facultad de Ciencias Naturales y Museo, Universidad Nacional de La Plata, Calle 64 N° 3, B1904AMA La Plata, Argentina.No affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

23273868

Citation

Vera-Candioti, Josefina, et al. "Evaluation of the Genotoxic and Cytotoxic Effects of Glyphosate-based Herbicides in the Ten Spotted Live-bearer Fish Cnesterodon Decemmaculatus (Jenyns, 1842)." Ecotoxicology and Environmental Safety, vol. 89, 2013, pp. 166-73.
Vera-Candioti J, Soloneski S, Larramendy ML. Evaluation of the genotoxic and cytotoxic effects of glyphosate-based herbicides in the ten spotted live-bearer fish Cnesterodon decemmaculatus (Jenyns, 1842). Ecotoxicol Environ Saf. 2013;89:166-73.
Vera-Candioti, J., Soloneski, S., & Larramendy, M. L. (2013). Evaluation of the genotoxic and cytotoxic effects of glyphosate-based herbicides in the ten spotted live-bearer fish Cnesterodon decemmaculatus (Jenyns, 1842). Ecotoxicology and Environmental Safety, 89, 166-73. https://doi.org/10.1016/j.ecoenv.2012.11.028
Vera-Candioti J, Soloneski S, Larramendy ML. Evaluation of the Genotoxic and Cytotoxic Effects of Glyphosate-based Herbicides in the Ten Spotted Live-bearer Fish Cnesterodon Decemmaculatus (Jenyns, 1842). Ecotoxicol Environ Saf. 2013;89:166-73. PubMed PMID: 23273868.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Evaluation of the genotoxic and cytotoxic effects of glyphosate-based herbicides in the ten spotted live-bearer fish Cnesterodon decemmaculatus (Jenyns, 1842). AU - Vera-Candioti,Josefina, AU - Soloneski,Sonia, AU - Larramendy,Marcelo L, Y1 - 2012/12/25/ PY - 2012/08/13/received PY - 2012/10/31/revised PY - 2012/11/28/accepted PY - 2013/1/1/entrez PY - 2013/1/1/pubmed PY - 2013/6/1/medline SP - 166 EP - 73 JF - Ecotoxicology and environmental safety JO - Ecotoxicol Environ Saf VL - 89 N2 - Mortality, genotoxicity, and cytotoxicity of the 48% glyphosate-based formulations Panzer and Credit(®) were evaluated on Cnesterodon decemmaculatus (Jenyns, 1842) (Pisces, Poeciliidae) under laboratory conditions. Induction of micronuclei (MN) and alterations in the erythrocytes:erythroblasts ratio were employed as end points for genotoxicity and cytotoxicity, respectively. For Panzer(®), mean values of 16.70 and 15.68 mg/L were determined for LC(50) at 24 and 96 h, respectively, and these concentrations reached mean values of 98.50 and 91.73 mg/L for Credit(®). LC(50) values decreased as a negative linear function of Panzer(®) exposure time within the 0-96 h period, but not for Credit(®). LC(50) values indicated that the fish were more sensitive to Panzer(®) than to Credit(®). Both 3.9 and 7.8 mg/L of Panzer(®) increased MN frequency at 48 and 96 h of treatment. When fish were exposed to Credit(®), an increased frequency of MN over control values was found after 96 h for all concentrations assayed, but not after 48 h. No cellular cytotoxicity was found after Panzer(®) and Credit(®) treatment, regardless of both the concentration and the sampling time. Furthermore, our results demonstrated that Panzer(®) and Credit(®) should be considered as glyphosate-based commercial formulations with genotoxic but not cytotoxic effect properties. SN - 1090-2414 UR - https://www.unboundmedicine.com/medline/citation/23273868/Evaluation_of_the_genotoxic_and_cytotoxic_effects_of_glyphosate_based_herbicides_in_the_ten_spotted_live_bearer_fish_Cnesterodon_decemmaculatus__Jenyns_1842__ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0147-6513(12)00448-4 DB - PRIME DP - Unbound Medicine ER -