TY - JOUR T1 - The role of thiamine in HIV infection. AU - L Ng,Khanh vinh quốc, AU - Nguyễn,Lan Thi Hoàng, Y1 - 2012/12/28/ PY - 2012/11/05/received PY - 2012/11/21/revised PY - 2012/11/24/accepted PY - 2013/1/1/entrez PY - 2013/1/1/pubmed PY - 2013/9/18/medline SP - e221 EP - 7 JF - International journal of infectious diseases : IJID : official publication of the International Society for Infectious Diseases JO - Int J Infect Dis VL - 17 IS - 4 N2 - Patients infected with HIV have a high prevalence of thiamine deficiency. Genetic studies have provided the opportunity to determine which proteins link thiamine to HIV pathology, i.e., renin-angiotensin system, poly(ADP-ribosyl) polymerase 1, Sp1 promoter gene, transcription factor p53, apoptotic factor caspase 3, and glycogen synthetase kinase 3β. Thiamine also affects HIV through non-genomic factors, i.e., matrix metalloproteinase, vascular endothelial growth factor, heme oxygenase 1, the prostaglandins, cyclooxygenase 2, reactive oxygen species, and nitric oxide. In conclusion, thiamine may benefit HIV patients, but further investigation of the role of thiamine in HIV infection is needed. SN - 1878-3511 UR - https://www.unboundmedicine.com/medline/citation/23274124/The_role_of_thiamine_in_HIV_infection_ DB - PRIME DP - Unbound Medicine ER -