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Intracytoplasmic morphologically selected sperm injection (IMSI) after repeated IVF or ICSI failures: a prospective comparative study.
Eur J Obstet Gynecol Reprod Biol. 2013 Mar; 167(1):76-80.EJ

Abstract

OBJECTIVE

Sperm morphology plays a significant role in assisted reproductive technologies and is associated with high implantation rates. The objective of this study was to evaluate the outcome of intracytoplasmic morphologically selected sperm injection (IMSI) after repeated failures of conventional in vitro fertilization (IVF) or intracytoplasmic sperm injection (ICSI) techniques.

STUDY DESIGN

In a prospective study in which couples acted as their own controls, 75 infertile couples were offered IMSI after at least two previous IVF or ICSI failures. The main outcome measures were embryo quality and number of blastocysts obtained.

RESULTS

The percentage of top quality embryos obtained at day 2 was increased in IMSI compared to IVF/ICSI cycles (89.8% versus 79.8%; p=0.009). Extended embryo culture was possible in 41.3% of IMSI cycles versus 26.7% of IVF/ICSI cycles (p=0.04), and the mean number of blastocysts obtained was higher in IMSI cycles (1.5±1.9) than in IVF/ICSI cycles (1.0±1.2) (p=0.03). Moreover, IMSI resulted in clinical pregnancy and birth rates of respectively 29.3% and 18.6%.

CONCLUSION

After two or three IVF/ICSI failures, IMSI seems to give better embryo quality and more blastocysts, which allow more embryo transfers at the blastocyst stage. This study supports the use of sperm ultramorphology examination as an independent test to be proposed after repeated IVF or ICSI failures.

Authors+Show Affiliations

Department of Obstetrics, Gynaecology and Reproductive Medicine, Bichat-Claude Bernard University Hospital, Paris, France.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Comparative Study
Controlled Clinical Trial
Journal Article

Language

eng

PubMed ID

23276454

Citation

Delaroche, Lucie, et al. "Intracytoplasmic Morphologically Selected Sperm Injection (IMSI) After Repeated IVF or ICSI Failures: a Prospective Comparative Study." European Journal of Obstetrics, Gynecology, and Reproductive Biology, vol. 167, no. 1, 2013, pp. 76-80.
Delaroche L, Yazbeck C, Gout C, et al. Intracytoplasmic morphologically selected sperm injection (IMSI) after repeated IVF or ICSI failures: a prospective comparative study. Eur J Obstet Gynecol Reprod Biol. 2013;167(1):76-80.
Delaroche, L., Yazbeck, C., Gout, C., Kahn, V., Oger, P., & Rougier, N. (2013). Intracytoplasmic morphologically selected sperm injection (IMSI) after repeated IVF or ICSI failures: a prospective comparative study. European Journal of Obstetrics, Gynecology, and Reproductive Biology, 167(1), 76-80. https://doi.org/10.1016/j.ejogrb.2012.11.011
Delaroche L, et al. Intracytoplasmic Morphologically Selected Sperm Injection (IMSI) After Repeated IVF or ICSI Failures: a Prospective Comparative Study. Eur J Obstet Gynecol Reprod Biol. 2013;167(1):76-80. PubMed PMID: 23276454.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Intracytoplasmic morphologically selected sperm injection (IMSI) after repeated IVF or ICSI failures: a prospective comparative study. AU - Delaroche,Lucie, AU - Yazbeck,Chadi, AU - Gout,Clémence, AU - Kahn,Vanessa, AU - Oger,Pierre, AU - Rougier,Nathalie, Y1 - 2012/12/29/ PY - 2012/05/17/received PY - 2012/10/16/revised PY - 2012/11/24/accepted PY - 2013/1/2/entrez PY - 2013/1/2/pubmed PY - 2013/10/1/medline SP - 76 EP - 80 JF - European journal of obstetrics, gynecology, and reproductive biology JO - Eur. J. Obstet. Gynecol. Reprod. Biol. VL - 167 IS - 1 N2 - OBJECTIVE: Sperm morphology plays a significant role in assisted reproductive technologies and is associated with high implantation rates. The objective of this study was to evaluate the outcome of intracytoplasmic morphologically selected sperm injection (IMSI) after repeated failures of conventional in vitro fertilization (IVF) or intracytoplasmic sperm injection (ICSI) techniques. STUDY DESIGN: In a prospective study in which couples acted as their own controls, 75 infertile couples were offered IMSI after at least two previous IVF or ICSI failures. The main outcome measures were embryo quality and number of blastocysts obtained. RESULTS: The percentage of top quality embryos obtained at day 2 was increased in IMSI compared to IVF/ICSI cycles (89.8% versus 79.8%; p=0.009). Extended embryo culture was possible in 41.3% of IMSI cycles versus 26.7% of IVF/ICSI cycles (p=0.04), and the mean number of blastocysts obtained was higher in IMSI cycles (1.5±1.9) than in IVF/ICSI cycles (1.0±1.2) (p=0.03). Moreover, IMSI resulted in clinical pregnancy and birth rates of respectively 29.3% and 18.6%. CONCLUSION: After two or three IVF/ICSI failures, IMSI seems to give better embryo quality and more blastocysts, which allow more embryo transfers at the blastocyst stage. This study supports the use of sperm ultramorphology examination as an independent test to be proposed after repeated IVF or ICSI failures. SN - 1872-7654 UR - https://www.unboundmedicine.com/medline/citation/23276454/Intracytoplasmic_morphologically_selected_sperm_injection__IMSI__after_repeated_IVF_or_ICSI_failures:_a_prospective_comparative_study_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0301-2115(12)00532-5 DB - PRIME DP - Unbound Medicine ER -