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The role of endocannabinoids in pain modulation.
Fundam Clin Pharmacol. 2013 Feb; 27(1):64-80.FC

Abstract

The endocannabinoid system (ES) is comprised of cannabinoid (CB) receptors, their endogenous ligands (endocannabinoids), and proteins responsible for their metabolism. Endocannabinoids serve as retrograde signaling messengers in GABAergic and glutamatergic synapses, as well as modulators of postsynaptic transmission, that interact with other neurotransmitters. Physiological stimuli and pathological conditions lead to differential increases in brain endocannabinoids that regulate distinct biological functions. Furthermore, endocannabinoids modulate neuronal, glial, and endothelial cell function and exert neuromodulatory, anti-excitotoxic, anti-inflammatory, and vasodilatory effects. Analgesia is one of the principal therapeutic targets of cannabinoids. Cannabinoid analgesia is based on the suppression of spinal and thalamic nociceptive neurons, but peripheral sites of action have also been identified. The chronic pain that occasionally follows peripheral nerve injury differs fundamentally from inflammatory pain and is an area of considerable unmet therapeutic need. Over the last years, considerable progress has been made in understanding the role of the ES in the modulation of pain. Endocannabinoids have been shown to behave as analgesics in models of both acute nociception and clinical pain such as inflammation and painful neuropathy. The framework for such analgesic effects exists in the CB receptors, which are found in areas of the nervous system important for pain processing and in immune cells that regulate the neuro-immune interactions that mediate the inflammatory hyperalgesia. The purpose of this review is to present the available research and clinical data, up to date, regarding the ES and its role in pain modulation, as well as its possible therapeutic perspectives.

Authors+Show Affiliations

First Department of Pathology, Medical School, University of Athens, Goudi, Athens, Greece.No affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Review

Language

eng

PubMed ID

23278562

Citation

Zogopoulos, Panagiotis, et al. "The Role of Endocannabinoids in Pain Modulation." Fundamental & Clinical Pharmacology, vol. 27, no. 1, 2013, pp. 64-80.
Zogopoulos P, Vasileiou I, Patsouris E, et al. The role of endocannabinoids in pain modulation. Fundam Clin Pharmacol. 2013;27(1):64-80.
Zogopoulos, P., Vasileiou, I., Patsouris, E., & Theocharis, S. E. (2013). The role of endocannabinoids in pain modulation. Fundamental & Clinical Pharmacology, 27(1), 64-80. https://doi.org/10.1111/fcp.12008
Zogopoulos P, et al. The Role of Endocannabinoids in Pain Modulation. Fundam Clin Pharmacol. 2013;27(1):64-80. PubMed PMID: 23278562.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - The role of endocannabinoids in pain modulation. AU - Zogopoulos,Panagiotis, AU - Vasileiou,Ioanna, AU - Patsouris,Efstratios, AU - Theocharis,Stamatios E, Y1 - 2013/01/02/ PY - 2011/11/28/received PY - 2012/09/03/revised PY - 2012/09/21/accepted PY - 2013/1/3/entrez PY - 2013/1/3/pubmed PY - 2013/6/26/medline SP - 64 EP - 80 JF - Fundamental & clinical pharmacology JO - Fundam Clin Pharmacol VL - 27 IS - 1 N2 - The endocannabinoid system (ES) is comprised of cannabinoid (CB) receptors, their endogenous ligands (endocannabinoids), and proteins responsible for their metabolism. Endocannabinoids serve as retrograde signaling messengers in GABAergic and glutamatergic synapses, as well as modulators of postsynaptic transmission, that interact with other neurotransmitters. Physiological stimuli and pathological conditions lead to differential increases in brain endocannabinoids that regulate distinct biological functions. Furthermore, endocannabinoids modulate neuronal, glial, and endothelial cell function and exert neuromodulatory, anti-excitotoxic, anti-inflammatory, and vasodilatory effects. Analgesia is one of the principal therapeutic targets of cannabinoids. Cannabinoid analgesia is based on the suppression of spinal and thalamic nociceptive neurons, but peripheral sites of action have also been identified. The chronic pain that occasionally follows peripheral nerve injury differs fundamentally from inflammatory pain and is an area of considerable unmet therapeutic need. Over the last years, considerable progress has been made in understanding the role of the ES in the modulation of pain. Endocannabinoids have been shown to behave as analgesics in models of both acute nociception and clinical pain such as inflammation and painful neuropathy. The framework for such analgesic effects exists in the CB receptors, which are found in areas of the nervous system important for pain processing and in immune cells that regulate the neuro-immune interactions that mediate the inflammatory hyperalgesia. The purpose of this review is to present the available research and clinical data, up to date, regarding the ES and its role in pain modulation, as well as its possible therapeutic perspectives. SN - 1472-8206 UR - https://www.unboundmedicine.com/medline/citation/23278562/The_role_of_endocannabinoids_in_pain_modulation_ L2 - https://doi.org/10.1111/fcp.12008 DB - PRIME DP - Unbound Medicine ER -