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Hydroxyurea therapy in sickle cell anemia patients aids to maintain oral fungal colonization balance.
J Oral Pathol Med. 2013 Aug; 42(7):570-5.JO

Abstract

BACKGROUND

The aim of this study was to evaluate the frequency of Candida species and presence of lesions in the oral cavity of patients with sickle cell anemia (SS).

METHODS

The study included 30 patients diagnosed with sickle cell anemia and taking hydroxyurea for at least 90 days (SS/HU+); and 39 patients with sickle cell anemia and without hydroxyurea therapy (SS/HU-). Two control groups were constituted by healthy individuals matched to the test groups in age, gender, and oral conditions (C/HU+ for SS/HU+ and C/HU- for SS/HU-). Oral clinical examination and anamnesis were performed. Yeasts were collected by oral rinses and identified by API system. Antifungal susceptibility evaluation was performed according to the CLSI methodology. Data obtained for microorganisms counts were compared by Student's t test (SS/HU+ vs. C/HU+ and SS/HU- vs. C/HU-) using MINITAB for Windows 1.4. Significance level was set at 5%.

RESULTS

No oral candidosis lesions were detected. Significant differences in yeasts counts were observed between SS/HU- group and the respective control, but there were no differences between SS/HU+ and C/HU+. Candida albicans was the most prevalent species in all groups. Candida famata was observed both in SS and control groups. Candida dubliniensis, Candida glabrata, Candida krusei, Candida tropicalis, Candida pelliculosa, and Candida parapsilosis were observed only in SS groups. Most strains were susceptible to all antifungal agents.

CONCLUSION

Hydroxyurea therapy seems to decrease candidal counts and resistance rate in sickle cell anemia patients. However, further studies should be conducted in the future to confirm this finding. Hydroxyurea therapy in sickle cell anemia patients maintains fungal species balance in oral cavity.

Authors+Show Affiliations

Univ. Estadual Paulista/UNESP, São José dos Campos, Brazil.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Comparative Study
Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

23278631

Citation

Salvia, Ana Carolina Rodrigues Danzi, et al. "Hydroxyurea Therapy in Sickle Cell Anemia Patients Aids to Maintain Oral Fungal Colonization Balance." Journal of Oral Pathology & Medicine : Official Publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology, vol. 42, no. 7, 2013, pp. 570-5.
Salvia AC, Figueiredo MS, Braga JA, et al. Hydroxyurea therapy in sickle cell anemia patients aids to maintain oral fungal colonization balance. J Oral Pathol Med. 2013;42(7):570-5.
Salvia, A. C., Figueiredo, M. S., Braga, J. A., Pereira, D. F., Brighenti, F. L., & Koga-Ito, C. Y. (2013). Hydroxyurea therapy in sickle cell anemia patients aids to maintain oral fungal colonization balance. Journal of Oral Pathology & Medicine : Official Publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology, 42(7), 570-5. https://doi.org/10.1111/jop.12029
Salvia AC, et al. Hydroxyurea Therapy in Sickle Cell Anemia Patients Aids to Maintain Oral Fungal Colonization Balance. J Oral Pathol Med. 2013;42(7):570-5. PubMed PMID: 23278631.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Hydroxyurea therapy in sickle cell anemia patients aids to maintain oral fungal colonization balance. AU - Salvia,Ana Carolina Rodrigues Danzi, AU - Figueiredo,Maria Stella, AU - Braga,Josefina Aparecida Pellegrini, AU - Pereira,Daniel Freitas Alves, AU - Brighenti,Fernanda Lourenção, AU - Koga-Ito,C Y, Y1 - 2012/12/26/ PY - 2012/11/17/accepted PY - 2013/1/3/entrez PY - 2013/1/3/pubmed PY - 2014/3/29/medline KW - antifungals KW - hydroxyurea KW - microbiology KW - oral cavity KW - sickle cell anemia SP - 570 EP - 5 JF - Journal of oral pathology & medicine : official publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology JO - J. Oral Pathol. Med. VL - 42 IS - 7 N2 - BACKGROUND: The aim of this study was to evaluate the frequency of Candida species and presence of lesions in the oral cavity of patients with sickle cell anemia (SS). METHODS: The study included 30 patients diagnosed with sickle cell anemia and taking hydroxyurea for at least 90 days (SS/HU+); and 39 patients with sickle cell anemia and without hydroxyurea therapy (SS/HU-). Two control groups were constituted by healthy individuals matched to the test groups in age, gender, and oral conditions (C/HU+ for SS/HU+ and C/HU- for SS/HU-). Oral clinical examination and anamnesis were performed. Yeasts were collected by oral rinses and identified by API system. Antifungal susceptibility evaluation was performed according to the CLSI methodology. Data obtained for microorganisms counts were compared by Student's t test (SS/HU+ vs. C/HU+ and SS/HU- vs. C/HU-) using MINITAB for Windows 1.4. Significance level was set at 5%. RESULTS: No oral candidosis lesions were detected. Significant differences in yeasts counts were observed between SS/HU- group and the respective control, but there were no differences between SS/HU+ and C/HU+. Candida albicans was the most prevalent species in all groups. Candida famata was observed both in SS and control groups. Candida dubliniensis, Candida glabrata, Candida krusei, Candida tropicalis, Candida pelliculosa, and Candida parapsilosis were observed only in SS groups. Most strains were susceptible to all antifungal agents. CONCLUSION: Hydroxyurea therapy seems to decrease candidal counts and resistance rate in sickle cell anemia patients. However, further studies should be conducted in the future to confirm this finding. Hydroxyurea therapy in sickle cell anemia patients maintains fungal species balance in oral cavity. SN - 1600-0714 UR - https://www.unboundmedicine.com/medline/citation/23278631/Hydroxyurea_therapy_in_sickle_cell_anemia_patients_aids_to_maintain_oral_fungal_colonization_balance_ L2 - https://doi.org/10.1111/jop.12029 DB - PRIME DP - Unbound Medicine ER -