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Comparison of pleural N-terminal pro-B-type natriuretic peptide, midregion pro-atrial natriuretic peptide and mid-region pro-adrenomedullin for the diagnosis of pleural effusions associated with cardiac failure.
Respirology. 2013 Apr; 18(3):540-5.R

Abstract

BACKGROUND AND OBJECTIVE

The purpose of this study was to compare the diagnostic utility of pleural fluid N-terminal pro-B-type natriuretic peptide (NT-proBNP), midregion pro-atrial natriuretic peptide (MR-proANP) and midregion pro-adrenomedullin (MR-proADM) for discriminating heart failure (HF)-associated effusions.

METHODS

NT-proBNP, MR-proANP and MR-proADM were measured by commercially available methodologies in the pleural fluid of a retrospective cohort of 185 consecutive patients with pleural effusions, of whom 95 had acute decompensated HF. Receiver-operating characteristic and area under the curve (AUC) analyses allowed comparisons of the discriminative properties of these biomarkers to be made at their optimal cut-off points.

RESULTS

The diagnostic accuracy of NT-proBNP and MR-proANP for HF as quantified by the AUC was 0.935 and 0.918, respectively, whereas MR-proADM was of limited value (AUC = 0.62). A pleural fluid MR-proANP >260 pmol/L or NT-proBNP >1700 pg/mL argues for HF (likelihood ratio (LR) positive >5), while levels below these cut-off values significantly decrease the probability of having the disease (respective LR negative 0.19 and 0.10). The optimal cut-off points for natriuretic peptides were influenced by age, renal function and body mass index. Finally, both NT-proBNP and the albumin gradient correctly identified more than 80% of those cardiac effusions misclassified as exudates by standard criteria.

CONCLUSIONS

MR-proANP is as valuable a diagnostic tool as NT-proBNP for diagnosing or excluding HF as the cause of pleural effusion.

Authors+Show Affiliations

Pleural Diseases Unit, Department of Internal Medicine, Arnau de Vilanova University Hospital, Biomedical Research Institute of Lleida, Lleida, Spain. jporcelp@yahoo.esNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Comparative Study
Journal Article

Language

eng

PubMed ID

23278975

Citation

Porcel, José M., et al. "Comparison of Pleural N-terminal pro-B-type Natriuretic Peptide, Midregion Pro-atrial Natriuretic Peptide and Mid-region Pro-adrenomedullin for the Diagnosis of Pleural Effusions Associated With Cardiac Failure." Respirology (Carlton, Vic.), vol. 18, no. 3, 2013, pp. 540-5.
Porcel JM, Bielsa S, Morales-Rull JL, et al. Comparison of pleural N-terminal pro-B-type natriuretic peptide, midregion pro-atrial natriuretic peptide and mid-region pro-adrenomedullin for the diagnosis of pleural effusions associated with cardiac failure. Respirology. 2013;18(3):540-5.
Porcel, J. M., Bielsa, S., Morales-Rull, J. L., Civit, C., Cao, G., Light, R. W., & Esquerda, A. (2013). Comparison of pleural N-terminal pro-B-type natriuretic peptide, midregion pro-atrial natriuretic peptide and mid-region pro-adrenomedullin for the diagnosis of pleural effusions associated with cardiac failure. Respirology (Carlton, Vic.), 18(3), 540-5. https://doi.org/10.1111/resp.12039
Porcel JM, et al. Comparison of Pleural N-terminal pro-B-type Natriuretic Peptide, Midregion Pro-atrial Natriuretic Peptide and Mid-region Pro-adrenomedullin for the Diagnosis of Pleural Effusions Associated With Cardiac Failure. Respirology. 2013;18(3):540-5. PubMed PMID: 23278975.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Comparison of pleural N-terminal pro-B-type natriuretic peptide, midregion pro-atrial natriuretic peptide and mid-region pro-adrenomedullin for the diagnosis of pleural effusions associated with cardiac failure. AU - Porcel,José M, AU - Bielsa,Silvia, AU - Morales-Rull,José L, AU - Civit,Carme, AU - Cao,Gonzalo, AU - Light,Richard W, AU - Esquerda,Aureli, PY - 2012/08/08/received PY - 2012/10/14/revised PY - 2012/10/21/accepted PY - 2013/1/3/entrez PY - 2013/1/3/pubmed PY - 2013/9/26/medline SP - 540 EP - 5 JF - Respirology (Carlton, Vic.) JO - Respirology VL - 18 IS - 3 N2 - BACKGROUND AND OBJECTIVE: The purpose of this study was to compare the diagnostic utility of pleural fluid N-terminal pro-B-type natriuretic peptide (NT-proBNP), midregion pro-atrial natriuretic peptide (MR-proANP) and midregion pro-adrenomedullin (MR-proADM) for discriminating heart failure (HF)-associated effusions. METHODS: NT-proBNP, MR-proANP and MR-proADM were measured by commercially available methodologies in the pleural fluid of a retrospective cohort of 185 consecutive patients with pleural effusions, of whom 95 had acute decompensated HF. Receiver-operating characteristic and area under the curve (AUC) analyses allowed comparisons of the discriminative properties of these biomarkers to be made at their optimal cut-off points. RESULTS: The diagnostic accuracy of NT-proBNP and MR-proANP for HF as quantified by the AUC was 0.935 and 0.918, respectively, whereas MR-proADM was of limited value (AUC = 0.62). A pleural fluid MR-proANP >260 pmol/L or NT-proBNP >1700 pg/mL argues for HF (likelihood ratio (LR) positive >5), while levels below these cut-off values significantly decrease the probability of having the disease (respective LR negative 0.19 and 0.10). The optimal cut-off points for natriuretic peptides were influenced by age, renal function and body mass index. Finally, both NT-proBNP and the albumin gradient correctly identified more than 80% of those cardiac effusions misclassified as exudates by standard criteria. CONCLUSIONS: MR-proANP is as valuable a diagnostic tool as NT-proBNP for diagnosing or excluding HF as the cause of pleural effusion. SN - 1440-1843 UR - https://www.unboundmedicine.com/medline/citation/23278975/Comparison_of_pleural_N_terminal_pro_B_type_natriuretic_peptide_midregion_pro_atrial_natriuretic_peptide_and_mid_region_pro_adrenomedullin_for_the_diagnosis_of_pleural_effusions_associated_with_cardiac_failure_ L2 - https://doi.org/10.1111/resp.12039 DB - PRIME DP - Unbound Medicine ER -