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Parental smoking and risk of childhood brain tumors.
Int J Cancer. 2013 Jul; 133(1):253-9.IJ

Abstract

Childhood brain tumors (CBT) are the leading cause of cancer death in children, yet their etiology remains largely unknown. Tobacco smoke contains 61 known carcinogens and increases the risk of several adult cancers. This study investigated associations between parental smoking and risk of CBT in a population-based case-control study conducted between 2005 and 2010. Cases were identified through all ten Australian pediatric oncology centers, controls via nationwide random-digit dialing, frequency matched to cases on age, sex and state of residence. Parental smoking information was obtained for 302 cases and 941 controls through mailed questionnaires that requested average daily cigarette use in each calendar year from age 15 to the child's birth, linked to residential and occupational histories. Data were analyzed using unconditional logistic regression, adjusting for frequency matching variables and potential confounders. Overall, parental smoking before or during pregnancy showed no association with CBT risk. The odds ratios for maternal smoking before and during pregnancy were 0.99 (95% CI: 0.70, 1.40) and 0.89 (95% CI: 0.61, 1.21), respectively, and those for paternal smoking before and during pregnancy were 0.99 (95% CI: 0.71, 1.38) and 1.04 (95% CI: 0.74, 1.46), respectively. In children under 24 months of age, the odds ratios for maternal smoking preconception and during pregnancy were 5.06 (95% CI 1.35-19.00) and 4.61 (95% CI: 1.08, 19.63), although these results were based on modest numbers. Future studies should investigate the associations between maternal smoking and risk of CBT by the child's age of diagnosis.

Authors+Show Affiliations

Telethon Institute for Child Health Research, Centre for Child Health Research, University of Western Australia, Perth, WA, Australia. lizm@ichr.uwa.edu.auNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

23280760

Citation

Milne, Elizabeth, et al. "Parental Smoking and Risk of Childhood Brain Tumors." International Journal of Cancer, vol. 133, no. 1, 2013, pp. 253-9.
Milne E, Greenop KR, Scott RJ, et al. Parental smoking and risk of childhood brain tumors. Int J Cancer. 2013;133(1):253-9.
Milne, E., Greenop, K. R., Scott, R. J., Ashton, L. J., Cohn, R. J., de Klerk, N. H., & Armstrong, B. K. (2013). Parental smoking and risk of childhood brain tumors. International Journal of Cancer, 133(1), 253-9. https://doi.org/10.1002/ijc.28004
Milne E, et al. Parental Smoking and Risk of Childhood Brain Tumors. Int J Cancer. 2013;133(1):253-9. PubMed PMID: 23280760.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Parental smoking and risk of childhood brain tumors. AU - Milne,Elizabeth, AU - Greenop,Kathryn R, AU - Scott,Rodney J, AU - Ashton,Lesley J, AU - Cohn,Richard J, AU - de Klerk,Nicholas H, AU - Armstrong,Bruce K, Y1 - 2013/02/13/ PY - 2012/09/06/received PY - 2012/11/22/revised PY - 2012/12/10/accepted PY - 2013/1/3/entrez PY - 2013/1/3/pubmed PY - 2013/6/12/medline SP - 253 EP - 9 JF - International journal of cancer JO - Int J Cancer VL - 133 IS - 1 N2 - Childhood brain tumors (CBT) are the leading cause of cancer death in children, yet their etiology remains largely unknown. Tobacco smoke contains 61 known carcinogens and increases the risk of several adult cancers. This study investigated associations between parental smoking and risk of CBT in a population-based case-control study conducted between 2005 and 2010. Cases were identified through all ten Australian pediatric oncology centers, controls via nationwide random-digit dialing, frequency matched to cases on age, sex and state of residence. Parental smoking information was obtained for 302 cases and 941 controls through mailed questionnaires that requested average daily cigarette use in each calendar year from age 15 to the child's birth, linked to residential and occupational histories. Data were analyzed using unconditional logistic regression, adjusting for frequency matching variables and potential confounders. Overall, parental smoking before or during pregnancy showed no association with CBT risk. The odds ratios for maternal smoking before and during pregnancy were 0.99 (95% CI: 0.70, 1.40) and 0.89 (95% CI: 0.61, 1.21), respectively, and those for paternal smoking before and during pregnancy were 0.99 (95% CI: 0.71, 1.38) and 1.04 (95% CI: 0.74, 1.46), respectively. In children under 24 months of age, the odds ratios for maternal smoking preconception and during pregnancy were 5.06 (95% CI 1.35-19.00) and 4.61 (95% CI: 1.08, 19.63), although these results were based on modest numbers. Future studies should investigate the associations between maternal smoking and risk of CBT by the child's age of diagnosis. SN - 1097-0215 UR - https://www.unboundmedicine.com/medline/citation/23280760/Parental_smoking_and_risk_of_childhood_brain_tumors_ L2 - https://doi.org/10.1002/ijc.28004 DB - PRIME DP - Unbound Medicine ER -