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Risk of thyroid cancer in a nationwide cohort of patients with biopsy-verified celiac disease.
Thyroid 2013; 23(8):971-6T

Abstract

BACKGROUND

In earlier studies based on selected populations, the relative risk for thyroid cancer in celiac disease has varied between 0.6 and 22.5. We aimed to test this relationship in a population-based setting.

METHODS

We collected small intestinal biopsy report data performed in 1969-2008 from all 28 Swedish pathology departments. 29,074 individuals with celiac disease (villous atrophy; Marsh histopathology stage III) were matched for sex, age, calendar year, and county to 144,440 reference individuals from the Swedish general population. Through Cox regression, we then estimated hazard ratios (HRs) and confidence intervals (CIs) for any thyroid cancer and papillary thyroid cancer (defined according to relevant pathology codes in the Swedish Cancer Register) in patients with celiac disease.

RESULTS

During follow-up, any thyroid cancer developed in seven patients with celiac disease (expected=12) and papillary thyroid cancer developed in five patients (expected=7). Celiac disease was not associated with an increased risk of any thyroid cancer (HR 0.6 [CI 0.3-1.3]) or of papillary thyroid cancer (HR 0.7 [CI 0.3-1.8]). All cases of thyroid cancer in celiac disease occurred in female patients. Risk estimates were similar before and after the year 2000 and independent of age at celiac diagnosis (≤24 years vs. ≥25 years).

CONCLUSIONS

We conclude that, in the Swedish population, there is no increased risk of thyroid cancer in patients with celiac disease. This differs from what has been reported in smaller studies in Italy and the United States.

Authors+Show Affiliations

Department of Medicine, Karolinska University Hospital and Karolinska Institute, Stockholm, Sweden. jonasludvigsson@yahoo.comNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

23281890

Citation

Ludvigsson, Jonas F., et al. "Risk of Thyroid Cancer in a Nationwide Cohort of Patients With Biopsy-verified Celiac Disease." Thyroid : Official Journal of the American Thyroid Association, vol. 23, no. 8, 2013, pp. 971-6.
Ludvigsson JF, Lebwohl B, Kämpe O, et al. Risk of thyroid cancer in a nationwide cohort of patients with biopsy-verified celiac disease. Thyroid. 2013;23(8):971-6.
Ludvigsson, J. F., Lebwohl, B., Kämpe, O., Murray, J. A., Green, P. H., & Ekbom, A. (2013). Risk of thyroid cancer in a nationwide cohort of patients with biopsy-verified celiac disease. Thyroid : Official Journal of the American Thyroid Association, 23(8), pp. 971-6. doi:10.1089/thy.2012.0306.
Ludvigsson JF, et al. Risk of Thyroid Cancer in a Nationwide Cohort of Patients With Biopsy-verified Celiac Disease. Thyroid. 2013;23(8):971-6. PubMed PMID: 23281890.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Risk of thyroid cancer in a nationwide cohort of patients with biopsy-verified celiac disease. AU - Ludvigsson,Jonas F, AU - Lebwohl,Benjamin, AU - Kämpe,Olle, AU - Murray,Joseph A, AU - Green,Peter H, AU - Ekbom,Anders, Y1 - 2013/07/22/ PY - 2013/1/4/entrez PY - 2013/1/4/pubmed PY - 2014/3/13/medline SP - 971 EP - 6 JF - Thyroid : official journal of the American Thyroid Association JO - Thyroid VL - 23 IS - 8 N2 - BACKGROUND: In earlier studies based on selected populations, the relative risk for thyroid cancer in celiac disease has varied between 0.6 and 22.5. We aimed to test this relationship in a population-based setting. METHODS: We collected small intestinal biopsy report data performed in 1969-2008 from all 28 Swedish pathology departments. 29,074 individuals with celiac disease (villous atrophy; Marsh histopathology stage III) were matched for sex, age, calendar year, and county to 144,440 reference individuals from the Swedish general population. Through Cox regression, we then estimated hazard ratios (HRs) and confidence intervals (CIs) for any thyroid cancer and papillary thyroid cancer (defined according to relevant pathology codes in the Swedish Cancer Register) in patients with celiac disease. RESULTS: During follow-up, any thyroid cancer developed in seven patients with celiac disease (expected=12) and papillary thyroid cancer developed in five patients (expected=7). Celiac disease was not associated with an increased risk of any thyroid cancer (HR 0.6 [CI 0.3-1.3]) or of papillary thyroid cancer (HR 0.7 [CI 0.3-1.8]). All cases of thyroid cancer in celiac disease occurred in female patients. Risk estimates were similar before and after the year 2000 and independent of age at celiac diagnosis (≤24 years vs. ≥25 years). CONCLUSIONS: We conclude that, in the Swedish population, there is no increased risk of thyroid cancer in patients with celiac disease. This differs from what has been reported in smaller studies in Italy and the United States. SN - 1557-9077 UR - https://www.unboundmedicine.com/medline/citation/23281890/Risk_of_thyroid_cancer_in_a_nationwide_cohort_of_patients_with_biopsy_verified_celiac_disease_ L2 - https://www.liebertpub.com/doi/full/10.1089/thy.2012.0306?url_ver=Z39.88-2003&rfr_id=ori:rid:crossref.org&rfr_dat=cr_pub=pubmed DB - PRIME DP - Unbound Medicine ER -