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Negative correlation between fetuin-A and indices of vascular disease in systemic lupus erythematosus patients with and without lupus nephritis.
Arab J Nephrol Transplant 2013; 6(1):11-20AJ

Abstract

INTRODUCTION

Fetuin-A, a systemic calcification inhibitor, has been negatively related to vascular calcification (VC) and cardiovascular mortality. In this study we investigated the association between fetuin-A levels and atherosclerotic vascular complications in systemic lupus erythematosus (SLE) patients with and without lupus nephritis (LN).

METHODS

We recruited 20 SLE patients without LN, 20 SLE patients with LN and 20 healthy controls. We determined serum creatinine, lipid profile, high sensitivity C-reactive protein (hsCRP), calcium, phosphate and fetuin-A levels, and calculated the calcification risk index (CRI) and SLE disease activity index (SLEDAI) for all subjects. Vascular disease burden was assessed by quantification of carotid artery intima-media-thickness (IMT) and the ankle-brachial index (ABI).

RESULTS

Fetuin-A levels were significantly lower in LN patients (0.47 ± 0.1 g/L) compared to SLE patients without LN (0.54 ± 0.1 g/L) and both were significantly lower than controls (0.78 ± 0.2 g/L). CRI was significantly higher in LN patients (89.1 ± 12.1 mg/L) compared to SLE patients without LN (67.2 ± 9.3 mg/L) and both were significantly higher than controls (34.2 ± 6.2 mg/L). Peripheral arterial disease (ABI > 0.9) was significantly more common in LN patients (55%) compared to SLE patients without LN (30%) as well as controls (0%). Fetuin-A levels showed significant negative correlations with serum creatinine, hsCRP, CRI, IMT and ABI in SLE patients with and without LN.

CONCLUSION

Fetuin-A levels were decreased in SLE patients with and without LN and negatively correlated with vascular complications. This suggests a potentially important role for fetuin-A deficiency as marker of vascular disease in SLE patients with and without LN.

Authors+Show Affiliations

Department of Pharmacology, Cairo University, Cairo, Egypt. alifatehi@hotmail.comNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

23282228

Citation

Abdel-Wahab, Ali F I., et al. "Negative Correlation Between fetuin-A and Indices of Vascular Disease in Systemic Lupus Erythematosus Patients With and Without Lupus Nephritis." Arab Journal of Nephrology and Transplantation, vol. 6, no. 1, 2013, pp. 11-20.
Abdel-Wahab AF, Fathy O, Al-Harizy R. Negative correlation between fetuin-A and indices of vascular disease in systemic lupus erythematosus patients with and without lupus nephritis. Arab J Nephrol Transplant. 2013;6(1):11-20.
Abdel-Wahab, A. F., Fathy, O., & Al-Harizy, R. (2013). Negative correlation between fetuin-A and indices of vascular disease in systemic lupus erythematosus patients with and without lupus nephritis. Arab Journal of Nephrology and Transplantation, 6(1), pp. 11-20.
Abdel-Wahab AF, Fathy O, Al-Harizy R. Negative Correlation Between fetuin-A and Indices of Vascular Disease in Systemic Lupus Erythematosus Patients With and Without Lupus Nephritis. Arab J Nephrol Transplant. 2013;6(1):11-20. PubMed PMID: 23282228.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Negative correlation between fetuin-A and indices of vascular disease in systemic lupus erythematosus patients with and without lupus nephritis. AU - Abdel-Wahab,Ali F I, AU - Fathy,Osama, AU - Al-Harizy,Randa, PY - 2013/1/4/entrez PY - 2013/1/4/pubmed PY - 2013/6/20/medline SP - 11 EP - 20 JF - Arab journal of nephrology and transplantation JO - Arab J Nephrol Transplant VL - 6 IS - 1 N2 - INTRODUCTION: Fetuin-A, a systemic calcification inhibitor, has been negatively related to vascular calcification (VC) and cardiovascular mortality. In this study we investigated the association between fetuin-A levels and atherosclerotic vascular complications in systemic lupus erythematosus (SLE) patients with and without lupus nephritis (LN). METHODS: We recruited 20 SLE patients without LN, 20 SLE patients with LN and 20 healthy controls. We determined serum creatinine, lipid profile, high sensitivity C-reactive protein (hsCRP), calcium, phosphate and fetuin-A levels, and calculated the calcification risk index (CRI) and SLE disease activity index (SLEDAI) for all subjects. Vascular disease burden was assessed by quantification of carotid artery intima-media-thickness (IMT) and the ankle-brachial index (ABI). RESULTS: Fetuin-A levels were significantly lower in LN patients (0.47 ± 0.1 g/L) compared to SLE patients without LN (0.54 ± 0.1 g/L) and both were significantly lower than controls (0.78 ± 0.2 g/L). CRI was significantly higher in LN patients (89.1 ± 12.1 mg/L) compared to SLE patients without LN (67.2 ± 9.3 mg/L) and both were significantly higher than controls (34.2 ± 6.2 mg/L). Peripheral arterial disease (ABI > 0.9) was significantly more common in LN patients (55%) compared to SLE patients without LN (30%) as well as controls (0%). Fetuin-A levels showed significant negative correlations with serum creatinine, hsCRP, CRI, IMT and ABI in SLE patients with and without LN. CONCLUSION: Fetuin-A levels were decreased in SLE patients with and without LN and negatively correlated with vascular complications. This suggests a potentially important role for fetuin-A deficiency as marker of vascular disease in SLE patients with and without LN. SN - 1858-554X UR - https://www.unboundmedicine.com/medline/citation/23282228/Negative_correlation_between_fetuin_A_and_indices_of_vascular_disease_in_systemic_lupus_erythematosus_patients_with_and_without_lupus_nephritis_ L2 - http://www.diseaseinfosearch.org/result/9373 DB - PRIME DP - Unbound Medicine ER -