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Probiotic Lactobacillus rhamnosus GG and Aloe vera gel improve lipid profiles in hypercholesterolemic rats.

Abstract

OBJECTIVE

The effects of Lactobacillus rhamnosus GG (LGG) and Aloe vera (AV) gel on lipid profiles in rats with induced hypercholesterolemia were studied.

METHODS

Five treatment groups of rats (n = 7) were the fed experimental diets: a normal control diet, a hypercholesterolemic diet (HD), HD + LGG, HD + AV gel, and HD + LGG + AV gel.

RESULTS

Supplementation with LGG decreased serum total cholesterol by 32%; however, in combination with AV, the decrease was 43%. The decreases in triacylglycerol levels in the HD + LGG, HD + AV, and HD + LGG + AV groups were 41%, 23% and 45%, respectively. High-density lipoprotein increased by 12% in the HD + LGG + AV group, whereas very low-density and low-density lipoprotein values decreased by 45% and 30%, respectively. The atherogenic index in the HD + LGG + AV group decreased to 2.45 from 4.77 in the HD + LGG group. Furthermore, fecal Lactobacillus species counts increased significantly when LGG was fed in combination with the AV gel. The oral administration of LGG fermented milk alone or in combination with the AV gel increased cholesterol synthesis (3-hydroxy-3-methylglutaryl coenzyme A reductase expression) and absorption (low-density lipoprotein receptor expression), whereas cholesterol 7α-hydroxylase mRNA expression levels were lower in the HD + LGG and HD + LGG + AV groups compared with the control HD group.

CONCLUSION

The combination of LGG and AV gel may have a therapeutic potential to decrease cholesterol levels and the risk of cardiovascular diseases.

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  • Authors+Show Affiliations

    ,

    Department of Microbiology and Immunology, National Institute of Nutrition, Hyderabad, India. manoj15micro@yahoo.co.in

    , , , , , , , , , , ,

    Source

    MeSH

    Aloe
    Animals
    Cardiovascular Diseases
    Cholesterol
    Cholesterol, Dietary
    Cholesterol, HDL
    Cholesterol, LDL
    Gels
    Hypercholesterolemia
    Lactobacillus rhamnosus
    Lipids
    Male
    Plant Extracts
    Probiotics
    Rats
    Rats, Wistar
    Risk Factors
    Triglycerides

    Pub Type(s)

    Journal Article

    Language

    eng

    PubMed ID

    23287067

    Citation

    Kumar, Manoj, et al. "Probiotic Lactobacillus Rhamnosus GG and Aloe Vera Gel Improve Lipid Profiles in Hypercholesterolemic Rats." Nutrition (Burbank, Los Angeles County, Calif.), vol. 29, no. 3, 2013, pp. 574-9.
    Kumar M, Rakesh S, Nagpal R, et al. Probiotic Lactobacillus rhamnosus GG and Aloe vera gel improve lipid profiles in hypercholesterolemic rats. Nutrition. 2013;29(3):574-9.
    Kumar, M., Rakesh, S., Nagpal, R., Hemalatha, R., Ramakrishna, A., Sudarshan, V., ... Kumar, R. (2013). Probiotic Lactobacillus rhamnosus GG and Aloe vera gel improve lipid profiles in hypercholesterolemic rats. Nutrition (Burbank, Los Angeles County, Calif.), 29(3), pp. 574-9. doi:10.1016/j.nut.2012.09.006.
    Kumar M, et al. Probiotic Lactobacillus Rhamnosus GG and Aloe Vera Gel Improve Lipid Profiles in Hypercholesterolemic Rats. Nutrition. 2013;29(3):574-9. PubMed PMID: 23287067.
    * Article titles in AMA citation format should be in sentence-case
    TY - JOUR T1 - Probiotic Lactobacillus rhamnosus GG and Aloe vera gel improve lipid profiles in hypercholesterolemic rats. AU - Kumar,Manoj, AU - Rakesh,Shruti, AU - Nagpal,Ravinder, AU - Hemalatha,R, AU - Ramakrishna,A, AU - Sudarshan,V, AU - Ramagoni,Ramesh, AU - Shujauddin,Mohd, AU - Verma,Vinod, AU - Kumar,Ashok, AU - Tiwari,Akhilesh, AU - Singh,Birbal, AU - Kumar,Rajesh, Y1 - 2013/01/01/ PY - 2012/03/18/received PY - 2012/06/29/revised PY - 2012/09/24/accepted PY - 2013/1/5/entrez PY - 2013/1/5/pubmed PY - 2013/7/31/medline SP - 574 EP - 9 JF - Nutrition (Burbank, Los Angeles County, Calif.) JO - Nutrition VL - 29 IS - 3 N2 - OBJECTIVE: The effects of Lactobacillus rhamnosus GG (LGG) and Aloe vera (AV) gel on lipid profiles in rats with induced hypercholesterolemia were studied. METHODS: Five treatment groups of rats (n = 7) were the fed experimental diets: a normal control diet, a hypercholesterolemic diet (HD), HD + LGG, HD + AV gel, and HD + LGG + AV gel. RESULTS: Supplementation with LGG decreased serum total cholesterol by 32%; however, in combination with AV, the decrease was 43%. The decreases in triacylglycerol levels in the HD + LGG, HD + AV, and HD + LGG + AV groups were 41%, 23% and 45%, respectively. High-density lipoprotein increased by 12% in the HD + LGG + AV group, whereas very low-density and low-density lipoprotein values decreased by 45% and 30%, respectively. The atherogenic index in the HD + LGG + AV group decreased to 2.45 from 4.77 in the HD + LGG group. Furthermore, fecal Lactobacillus species counts increased significantly when LGG was fed in combination with the AV gel. The oral administration of LGG fermented milk alone or in combination with the AV gel increased cholesterol synthesis (3-hydroxy-3-methylglutaryl coenzyme A reductase expression) and absorption (low-density lipoprotein receptor expression), whereas cholesterol 7α-hydroxylase mRNA expression levels were lower in the HD + LGG and HD + LGG + AV groups compared with the control HD group. CONCLUSION: The combination of LGG and AV gel may have a therapeutic potential to decrease cholesterol levels and the risk of cardiovascular diseases. SN - 1873-1244 UR - https://www.unboundmedicine.com/medline/citation/23287067/Probiotic_Lactobacillus_rhamnosus_GG_and_Aloe_vera_gel_improve_lipid_profiles_in_hypercholesterolemic_rats_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0899-9007(12)00362-0 DB - PRIME DP - Unbound Medicine ER -